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The Patient - Patient-Centered Outcomes Research

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01-02-2016 | Original Research Article

Preferences and Stated Adherence for Antibiotic Treatment of Cystic Fibrosis Pseudomonas Infections

Authors: Ateesha Farah Mohamed, F. Reed Johnson, Maria-Magdalena Balp, Frederico Calado

Published in: The Patient - Patient-Centered Outcomes Research | Issue 1/2016

Abstract

Objective

Our objective was to quantify preferences and stated adherence for inhaled antibiotic treatments in cystic fibrosis (CF).

Methods

Adult CF patients and parents of pediatric patients in the US who were members of the Cystic Fibrosis Foundation and who had Pseudomonas aeruginosa at least twice a year completed an online, discrete-choice experiment survey (response rate 4.4 %). Respondents answered five treatment-choice questions evaluating pairs of hypothetical CF treatment profiles. Stated-adherence questions followed two randomly selected treatment-choice questions. Data were analyzed using random-parameters logit (RPL). For a combination of attribute levels, the utility is estimated by summing the relevant attribute-level parameter estimates. For the stated-adherence questions, we tabulated the changes in the percentages of respondents who would be 95 % adherent for various changes in inhaled antibiotic-medication administration features.

Results

The final sample was 271 adult patients and 209 parents. Switching from a 30-min nebulizer twice daily to a 10-min dry powder inhaler (DPI) twice daily was 6.3 times more important for patients and 2.0 times more important for parents than an improvement in dry cough side effect from moderate to mild. Stated adherence for respondents was 20–30 % greater for DPIs versus nebulizers.

Conclusions

Lower frequency of administration, shorter administration times for a given device, and milder dry cough appear to improve stated adherence to antibiotic treatment of CF lung infections.

Available only for authorised users

Taste heterogeneity is differences in tastes across individuals. Controlling for taste heterogeneity overcomes the independence from irrelevant alternatives (IIA) property in choice models by creating correlations in the random component of utility that ‘break’the undesirable IIA property and allow any substitution pattern to be found.

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Title: Preferences and Stated Adherence for Antibiotic Treatment of Cystic Fibrosis Pseudomonas Infections
Authors: Ateesha Farah Mohamed
F. Reed Johnson
Maria-Magdalena Balp
Frederico Calado
Publication date: 01-02-2016
Publisher: Springer International Publishing
Published in: The Patient - Patient-Centered Outcomes Research / Issue 1/2016
Print ISSN: 1178-1653
Electronic ISSN: 1178-1661
DOI: https://doi.org/10.1007/s40271-015-0124-1

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