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Surgical Endoscopy
Published in: Surgical Endoscopy 5/2005

01-05-2005 | Original article

Predictors of survival after laparoscopic radiofrequency thermal ablation of hepatocellular cancer

A prospective study

Authors: E. Berber, S. Rogers, A. Siperstein

Published in: Surgical Endoscopy | Issue 5/2005

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Abstract

Background

Most patients with hepatocellular carcinoma (HCC) are not candidates for hepatic resection or liver transplantation. Radiofrequency ablation (RFA) provides local control for unresectable HCC with minimal morbidity. The aim of this prospective study is to determine factors predicting survival in patients with HCC undergoing RFA.

Methods

Sixty-six consecutive patients with HCC who were not candidates for a curative liver resection and were free of extrahepatic disease underwent laparoscopic RFA. The relationship between demographic, clinical, laboratory, and surgical parameters and survival was assessed using univariate Kaplan-Meier survival and multivariate Cox proportional hazards model.

Results

The median Kaplan-Meier survival for all patients was 25.3 months after RFA. Although alfa fetal protein (AFP), bilirubin, ascites, and Child class were statistically significant predictors of survival by univariate analysis, only the Child class and AFP were independent predictors by multivariate analysis.

Conclusions

This study determines which patients do best after RFA and shows that RFA can provide significant survival for patients with unresectable HCC while also forming a bridge to liver transplantation. RFA has become the first line of treatment in the management of these patients.
Literature
1.
Adam, R, Hagopian, EJ, Linhares, M, Krissat, J, Savier, E, Azoulay, D, Kunstlinger, F, Castaing, D, Bismuth, H 2002A comparison of percutaneous cryosurgery and percutaneous radiofrequency for unresectable hepatic malignanciesArch Surg13713321340PubMed
2.
Ariviadis, EA, Llovet, JM, Efremidis, SC, Shouval, D, Canelo, R, Ringe, B, Meyers, WC 1998Hepatocellular carcinomaBr J Surg8513191331
3.
Belghiti, J, Panis, Y, Farges, O, Benhamou, JP, Fekete, F 1991Intrahepatic recurrence after resection of hepatocellular carcinoma complicating cirrhosisAnn Surg214114117PubMed
4.
Berben, E (2001) “Liver cancer and resection” In: Ponsky, J (ed), The Cleveland Clinic guide to surgical patient management, St. Louis, Mosby, pp 151–158
5.
Berber, E, Flesher, NL, Siperstein, AE 2000Initial clinical evaluation of the RITA 5-centimeter radiofrequency thermal ablation catheter in the treatment of liver rumorsCancer J Sci Am6S319S329
6.
Curley, SA, Izzo, F, Ellis, LM, Nicolas Vauthey, J, Vallone, P 2000Radiofrequency ablation of hepatocellular cancer in 110 patients with cirrhosisAnn Surg232381391PubMed
7.
El-Serag, HB, Mason, AC, Key, C 2001Trends in survival of patients with hepatocellular carcinoma between 1977 and 1996 in the United StatesHepatology336265PubMed
8.
Fong., Y, Sun, RL, Jarnagin, W, Blumgart, LH 1999An analysis of 412 cases of hepatocellular carcinoma at a Western centerAnn Surg229790800CrossRefPubMed
9.
Iannitti, DA, Dupuy, DE, Mayo-Smith, WW, Murphy., B 2002Hepatic radiofrequency ablationArch Surg137422427CrossRefPubMed
10.
Jiao, LR, Hansen, PD, Havlik, R, Mitry, RR, Pignatelli, M, Habib, N 1999Clinical short-term results of radiofrequency ablation in primary and secondary liver tumorsAm J Surg177303306CrossRefPubMed
11.
Lau, WY, Leung, TW, Yu, SC, Ho, SK 2003Percutaneous local ablative therapy for hepatocellular carcinoma: a review and look into the futureAnn Surg237171179CrossRefPubMed
12.
Lee, WC, Jeng, LB, Chen, MF 2002Estimation of prognosis after hepatectomy for hepatocellular carcinomaBr J Surg89311316
13.
Livraghi, T, Bolondi, L, Lazzaroni, S, Marin, G, Morabito, A, Rapaccini, GL, Salmi, A, Torzilli, G 1992Percutaneous ethanol injection in the treatment of hepatocellular carcinoma in cirrhosisA study on 207 patients. Cancer69925929
14.
Livraghi, T, Giorgio, A, Marin, G,  et al. 1995Hepatocellular carcinoma and cirrhosis in 746 patients: long-term results of percutaneous ethanol injectionRadiology197101108PubMed
15.
Mazzaferro, V, Regalia., E, Doci, R, Andreola, S, Pulvirenti, A, Bozzetti, F, Montalto, F, Ammatuna, M, Morabito, A, Gennari, L 1996Liver transplantation for the treatment of small hepatpcellular carcinomas in patients with cirrhosisN Engl J Med334693699CrossRefPubMed
16.
Mor, E, Kaspa, RT, Sheiner, P, Schwartz, M 1998Treatment of hepatocellular carcinoma associated with cirrhosis in the era of liver transplantationAnn Intern Med129643653PubMed
17.
Nagasue, N, Kohno, H, Tachibana, M, Yamanoi, A, Ohmori, H, El-Assal, ON 1999Prognostic factors after hepatic resection for hepatocellular carcinoma associated with Child–Turcotte class B and C cirrhosisAnn Surg2298490PubMed
18.
Nagasue, N, Ono, T, Yamanoi, A, Kohno, H, El-Assal, ON, Taniura, H, Uchida, M 2001Prognostic factors and survival after hepatic resection for hepatocellular carcinoma without cirrhosisBr J Surg88515522
19.
Ringe, B, Pichlmayr, R, Wittekind, C, Tusch, G 1991Surgical treatment of hepatocellular carcinoma: experience with liver resection and transplantation in 198 patientsWorld J Surg15270285PubMed
20.
Siperstein, A, Garland, A, Engle, K, Rogers, S, Berber, E, String, A, Foroutani, A, Ryan, T 2000Laparoscopic radiofrequency ablation of primary and metastatic liver tumorsTechnical considerations. Surg Endosc14400405
21.
Siperstein A, Rogers SJ, Machi J, Goldstein R, Sielaff T (2002) Longterm follow-up of patients undergoing radiofrequency thermal ablation for primary and metastatic liver tumors: a multicenter trial [abstract]. American College of Surgeons Clinical Congress, October 2002, San Francisco
22.
Wantz, GE, Payne, MA 1961Experience with portacaval shunt for portal hypertensionN Engl J Med265721728PubMed
23.
Williams, I 1999Epidemiology of hepatitis C in the United StatesAm J Med1072S9S
Metadata
Title
Predictors of survival after laparoscopic radiofrequency thermal ablation of hepatocellular cancer
A prospective study
Authors
E. Berber
S. Rogers
A. Siperstein
Publication date
01-05-2005
Publisher
Springer-Verlag
Published in
Surgical Endoscopy / Issue 5/2005
Print ISSN: 0930-2794
Electronic ISSN: 1432-2218
DOI
https://doi.org/10.1007/s00464-004-8815-z

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