Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.
ADVANCED SEARCH
Log in
Top
Quality of Life Research
Published in: Quality of Life Research 9/2014

Open Access 01-11-2014

Predictors of health-related quality of life changes after lifestyle intervention in persons at risk of type 2 diabetes mellitus

Authors: Vegard Nilsen, Per Sigvald Bakke, Gudrun Rohde, Frode Gallefoss

Published in: Quality of Life Research | Issue 9/2014

Login to get access

Abstract

Purpose

To assess health-related quality of life (HRQOL) of subjects at risk of type 2 diabetes undergoing lifestyle intervention, and predictors for improved HRQOL.

Methods

The Finnish Diabetes Risk Score was used by general practitioners to identify individuals at risk. Low-intensity interventions with an 18-month follow-up were employed. HRQOL was assessed using the SF-36 at baseline and compared with results from a general Norwegian population survey and further at 6 and 18 months. Simple and multiple linear regression analyses were applied to identify predictors of changes in HRQOL of clinical importance.

Results

Two hundred and thirteen participants (50 % women; mean age: 46 years, mean body mass index: 37) were included: 182 returned for 18-month follow-up, of whom 172 completed the HRQOL questionnaire. HRQOL was reduced with clinical significance compared with general Norwegians. The mean changes in HRQOL from the baseline to the follow-up were not of clinical importance. However, one out of three individuals achieved a moderate or large clinical improvement in HRQOL. The best determinant for improved HRQOL was obtained for a composite, clinically significant lifestyle change, i.e. both a weight reduction of at least 5 % and an improvement in exercise capacity of at least 10 %, which was associated with an improvement in five out of the eight SF-36 domains.

Conclusion

Subjects at risk of type 2 diabetes report a clinically important reduction in HRQOL compared with general Norwegians. The best predictor of improved HRQOL was a small weight loss combined with a small improvement in aerobic capacity.
Literature
1.
Knowler, W. C., Barrett-Connor, E., Fowler, S. E., Hamman, R. F., Lachin, J. M., Walker, E. A., et al. (2002). Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. New England Journal of Medicine, 346, 393–403.PubMedCrossRef
2.
Pan, X. R., Li, G. W., Hu, Y. H., Wang, J. X., Yang, W. Y., An, Z. X., et al. (1997). Effects of diet and exercise in preventing NIDDM in people with impaired glucose tolerance. The Da Qing IGT and Diabetes Study. Diabetes Care, 20, 537–544.PubMedCrossRef
3.
Tuomilehto, J., Lindstrom, J., Eriksson, J. G., Valle, T. T., Hamalainen, H., Ilanne-Parikka, P., et al. (2001). Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance. New England Journal of Medicine, 344, 1343–1350.PubMedCrossRef
4.
Orozco, L. J., Buchleitner, A. M., Gimenez-Perez, G., Roqué i Figuls, M., Richter, B., Mauricio, D. (2008). Exercise or exercise and diet for preventing type 2 diabetes mellitus. Cochrane Database of Systematic Reviews, 3. Art. No.: CD003054. DOI: 10.​1002/​14651858.​CD003054.​pub3.
5.
Nield, L., Summerbell, C. D., Hooper, L., Whittaker, V., Moore, H. (2008). Dietary advice for the prevention of type 2 diabetes mellitus in adults. Cochrane Database of Systematic Reviews, 3. Art. No.: CD005102. DOI: 10.​1002/​14651858.​CD005102.​pub2.
6.
Fontaine, K. R., & Barofsky, I. (2001). Obesity and health-related quality of life. Obesity Reviews, 2, 173–182.PubMedCrossRef
7.
Kolotkin, R. L., Meter, K., & Williams, G. R. (2001). Quality of life and obesity. Obesity Reviews, 2, 219–229.PubMedCrossRef
8.
Wandell, P. E. (2005). Quality of life of patients with diabetes mellitus. An overview of research in primary health care in the Nordic countries. Scandinavian Journal of Primary Health Care, 23, 68–74.PubMedCrossRef
9.
Kolotkin, R. L., Crosby, R. D., Williams, G. R., Hartley, G. G., & Nicol, S. (2001). The relationship between health-related quality of life and weight loss. Obesity Research, 9, 564–571.PubMedCrossRef
10.
Maciejewski, M. L., Patrick, D. L., & Williamson, D. F. (2005). A structured review of randomized controlled trials of weight loss showed little improvement in health-related quality of life. Journal of Clinical Epidemiology, 58, 568–578.PubMedCrossRef
11.
Ross, K. M., Milsom, V. A., Rickel, K. A., Debraganza, N., Gibbons, L. M., Murawski, M. E., et al. (2009). The contributions of weight loss and increased physical fitness to improvements in health-related quality of life. Eating Behaviors, 10, 84–88.PubMedCrossRefPubMedCentral
12.
Ackermann, R. T., Edelstein, S. L., Narayan, K. M., Zhang, P., Engelgau, M. M., Herman, W. H., et al. (2009). Changes in health state utilities with changes in body mass in the Diabetes Prevention Program. Obesity (Silver Spring), 17, 2176–2181.CrossRef
13.
Schwarz, P. E., Li, J., Lindstrom, J., & Tuomilehto, J. (2009). Tools for predicting the risk of type 2 diabetes in daily practice. Hormone and Metabolic Research, 41, 86–97.PubMedCrossRef
14.
Nilsen, V., Bakke, P. S., & Gallefoss, F. (2011). Effects of lifestyle intervention in persons at risk for type 2 diabetes mellitus—results from a randomised, controlled trial. BMC Public Health, 11, 893.PubMedCrossRefPubMedCentral
15.
Loge, J. H., & Kaasa, S. (1998). Short form 36 (SF-36) health survey: normative data from the general Norwegian population. Scandinavian Journal of Social Medicine, 26, 250–258.PubMed
16.
Ware, J. E., Jr., Kosinski, M. (2001) Physical and mental health summary scales: A manual for users of version 1, 2nd edition. Quality Metric Incorporated.
17.
Statistics Norway (2004). Survey of living conditions 2002, cross-sectional survey. Oslo, Statistics Norway. Ref Type: Report.
18.
Crosby, R. D., Kolotkin, R. L., & Williams, G. R. (2003). Defining clinically meaningful change in health-related quality of life. Journal of Clinical Epidemiology, 56, 395–407.PubMedCrossRef
19.
Fayers, P. M., & Machin, D. (2007). Quality of life: Assessment, analysis and interpretation. Chichester: Wiley.CrossRef
20.
Revicki, D. A., Osoba, D., Fairclough, D., Barofsky, I., Berzon, R., Leidy, N. K., et al. (2000). Recommendations on health-related quality of life research to support labelling and promotional claims in the United States. Quality of Life Research, 9, 887–900.PubMedCrossRef
21.
Prause, W., Saletu, B., Tribl, G. G., Rieder, A., Rosenberger, A., Bolitschek, J., et al. (2005). Effects of socio-demographic variables on health-related quality of life determined by the quality of life index–German version. Human Psychopharmacology, 20, 359–365.PubMedCrossRef
22.
Dansinger, M. L., Tatsioni, A., Wong, J. B., Chung, M., & Balk, E. M. (2007). Meta-analysis: The effect of dietary counselling for weight loss. Annals of Internal Medicine, 147, 41–50.PubMedCrossRef
23.
Pinsky, P. F., Miller, A., Kramer, B. S., Church, T., Reding, D., Prorok, P., et al. (2007). Evidence of a healthy volunteer effect in the prostate, lung, colorectal, and ovarian cancer screening trial. American Journal of Epidemiology, 165, 874–881.PubMedCrossRef
24.
Jousilahti, P., Salomaa, V., Kuulasmaa, K., Niemela, M., & Vartiainen, E. (2005). Total and cause specific mortality among participants and non-participants of population based health surveys: A comprehensive follow up of 54 372 Finnish men and women. Journal of Epidemiology and Community Health, 59, 310–315.PubMedCrossRefPubMedCentral
25.
Kolotkin, R. L., Crosby, R. D., & Williams, G. R. (2002). Health-related quality of life varies among obese subgroups. Obesity Research, 10, 748–756.PubMedCrossRef
26.
van Nunen, A. M., Wouters, E. J., Vingerhoets, A. J., Hox, J. J., & Geenen, R. (2007). The health-related quality of life of obese persons seeking or not seeking surgical or non-surgical treatment: A meta-analysis. Obesity Surgery, 17, 1357–1366.PubMedCrossRefPubMedCentral
27.
Chittleborough, C. R., Baldock, K. L., Taylor, A. W., & Phillips, P. J. (2006). Health status assessed by the SF-36 along the diabetes continuum in an Australian population. Quality of Life Research, 15, 687–694.PubMedCrossRef
28.
Hakkinen, A., Kukka, A., Onatsu, T., Jarvenpaa, S., Heinonen, A., Kyrolainen, H., et al. (2009). Health-related quality of life and physical activity in persons at high risk for type 2 diabetes. Disability and Rehabilitation, 31, 799–805.PubMedCrossRef
Metadata
Title
Predictors of health-related quality of life changes after lifestyle intervention in persons at risk of type 2 diabetes mellitus
Authors
Vegard Nilsen
Per Sigvald Bakke
Gudrun Rohde
Frode Gallefoss
Publication date
01-11-2014
Publisher
Springer International Publishing
Published in
Quality of Life Research / Issue 9/2014
Print ISSN: 0962-9343
Electronic ISSN: 1573-2649
DOI
https://doi.org/10.1007/s11136-014-0702-z

Other articles of this Issue 9/2014

Quality of Life Research 9/2014 Go to the issue

OriginalPaper

The VEINES-QOL/Sym questionnaire is a reliable and valid disease-specific quality of life measure for deep vein thrombosis in elderly patients

OriginalPaper

Determinants of socioeconomic inequalities in subjective well-being in later life: a cross-country comparison in England and the USA

Response

A definition of recovery in myalgic encephalomyelitis and chronic fatigue syndrome should be based upon objective measures

OriginalPaper

Impact of psychological and cancer-related factors on HRQoL for Korean childhood cancer survivors

OriginalPaper

Self-reported health and satisfaction of patients with chronic diseases who meditate: a case–control study

Brief Communication

Assessing quality of life in middle-aged and older adults with HIV: psychometric testing of the WHOQOL-HIV-Bref