Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.
ADVANCED SEARCH
Log in
Top
Radiation Oncology
Published in: Radiation Oncology 1/2015

Open Access 01-12-2015 | Research

Predictive value of skin invasion in recurrent head and neck cancer patients treated by hypofractionated stereotactic re-irradiation using a cyberknife

Authors: Hideya Yamazaki, Mikio Ogita, Kengo Himei, Satoaki Nakamura, Gen Suzuki, Tadayuki Kotsuma, Ken Yoshida, Yasuo Yoshioka

Published in: Radiation Oncology | Issue 1/2015

Login to get access

Abstract

Background

This study aimed to elucidate the influence of skin invasion in patients with recurrent head and neck cancer treated with re-irradiation using stereotactic radiotherapy.

Materials

We reviewed 104 patients treated using CyberKnife in four institutions.

Results

Nine cases of skin invasion were recognized (8.6 %). Larger tumors tended to exhibit skin invasion. The skin invasion (+) group showed a lower response rate (0/9, 0 %) than the skin invasion (−) group (56/95, 59 %) (p = 0.002). The skin invasion (+) group showed lower local control (LC) and progression free survival (PFS) rates, both 0 % at 6 months, than the skin invasion (−) group, which had a LC of 69 % (p = 0.0001) and a PFS of 48 % at 1 year (p = 0.0157). Median survival time and one-year survival rates for the skin invasion (+) and (−) groups were 6.6 vs. 15.3 months and 14 % vs. 59 % (p = 0.0005), respectively. No patient with skin invasion survived more than 14.4 months. The percentage of patients who developed grade 3 or higher toxicity was 44 % in the skin invasion (+) group and 18 % in the skin invasion (−) group (p = 0.14).

Conclusions

Skin invasion is an important predictor of poor prognosis in recurrent head and neck cancer after re-irradiation with stereotactic radiation therapy.
Literature
1.
Mazeron R, Tao Y, Lusinchi A, Bourhis J. Current concepts of management in radiotherapy for head and neck squamous-cell cancer. Oral Oncol. 2009;45:402–8.CrossRefPubMed
2.
Vokes EE, Weichselbaum RR, Lippman SM, Hong WK. Head and neck cancer. N Eng J Med. 1993;328:184–94.CrossRef
3.
Temam S, Pape E, Janot F, Wibault P, Julieron M, Lusinchi A, et al. Salvage surgery after failure of very accelerated radiotherapy in advanced head-and-neck squamous cell carcinoma. Int J Radiat Oncol Biol Phys. 2005;62:1078–83.CrossRefPubMed
4.
Wong SJ, Machtay M, Li Y. Locally recurrent, previously irradiated head and neck cancer: concurrent reirradiation and chemotherapy, or chemotherapy alone? J Clin Oncol. 2006;24:2653–3658.CrossRefPubMed
5.
Lartigau EF, Tresch E, Thariat J, Graff P, Coche-Dequeant B, Benezery K, et al. Multi institutional phase II study of concomitant stereotactic reirradiation and cetuximab for recurrent head and neck cancer. Radiother Oncol. 2013;109:281–5.CrossRefPubMed
6.
Kress MA, Sen N, Unger KR, Lominska CE, Deeken JF, Davidson BJ, et al. Hypofractionated Stereotactic Body Re-irradiation in Head and Neck Cancer: Long-term follow-up of a large series demonstrates safety and efficacy. Head Neck (in press)
7.
Kodani N, Yamazaki H, Tsubokura T, Shiomi H, Kobayashi K, Nishimura T, et al. Stereotactic body radiation therapy for head and neck tumor: Disease control and morbidity outcomes. J Radiat Res. 2011;52:24–31.CrossRefPubMed
8.
Cengiz M, Özyiğit G, Yazici G, Doğan A, Yildiz F, Zorlu F, et al. Salvage reirradiaton with stereotactic body radiotherapy for locally recurrent head-and-neck tumors. Int J Radiat Oncol Biol Phys. 2011;81:104–9.CrossRefPubMed
9.
Yamazaki H, Ogita M, Kodani N, Nakamura S, Inoue H, Himei K, et al. Frequency, outcome and prognostic factors of carotid blowout syndrome after hypofractionated re-irradiation of head and neck cancer using CyberKnife: A multi-institutional study. Radiother Oncol. 2013;107:305–9.CrossRefPubMed
10.
Yamazaki H, Ogita M, Himei K, Nakamura S, Kotsuma T, Yoshida K, et al. Carotid blowout syndrome in pharyngeal cancer patients treated by hypofractionated stereotactic re-irradiation using CyberKnife: A multi-institutional matched-cohort analysis. Radiother Oncol. 2015;115:67–71.CrossRefPubMed
11.
Union for International Cancer Control (UICC). TNM Classification of Malignant Tumours. 7th ed. Oxford: Wiley-Blackwell; 2009.
12.
Vargo JA, Ferris RL, Ohr J, Clump DA, Davis KS, Duvvuri U, et al. A prospective phase 2 trial of reirradiation with stereotactic body radiation therapy plus cetuximab in patients with previously irradiated recurrent squamous cell carcinoma of the head and neck. Int J Radiat Oncol Biol Phys. 2015;91:480–8.CrossRefPubMed
13.
Duprez F, Berwouts D, Madani I, Bonte K, Boterberg T, De Gersem W, et al. High-dose reirradiation with intensity-modulated radiotherapy for recurrent head-and-neck cancer: disease control, survival and toxicity. Radiother Oncol. 2014;111:388–92.CrossRefPubMed
Metadata
Title
Predictive value of skin invasion in recurrent head and neck cancer patients treated by hypofractionated stereotactic re-irradiation using a cyberknife
Authors
Hideya Yamazaki
Mikio Ogita
Kengo Himei
Satoaki Nakamura
Gen Suzuki
Tadayuki Kotsuma
Ken Yoshida
Yasuo Yoshioka
Publication date
01-12-2015
Publisher
BioMed Central
Published in
Radiation Oncology / Issue 1/2015
Electronic ISSN: 1748-717X
DOI
https://doi.org/10.1186/s13014-015-0517-2

Other articles of this Issue 1/2015

Radiation Oncology 1/2015 Go to the issue

Research

Evaluation of the Machine Performance Check application for TrueBeam Linac

Research

Consecutive magnetic resonance imaging during brachytherapy for cervical carcinoma: predictive value of volume measurements with respect to persistent disease and prognosis

Research

Positioning accuracy during VMAT of gynecologic malignancies and the resulting dosimetric impact by a 6-degree-of-freedom couch in combination with daily kilovoltage cone beam computed tomography

Research

Radiation-induced bronchiolitis obliterans organizing pneumonia (BOOP) syndrome in breast cancer patients is associated with age

Research

Cellular uptake and in vitro antitumor efficacy of composite liposomes for neutron capture therapy

Research

Involved-field radiotherapy (IFRT) versus elective nodal irradiation (ENI) in combination with concurrent chemotherapy for 239 esophageal cancers: a single institutional retrospective study