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Journal of Assisted Reproduction and Genetics

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01-09-2014 | Assisted Reproduction Technologies

Predictive value of postwashed total progressively motile sperm count using CASA estimates in 6871 non-donor intrauterine insemination cycles

Authors: Orkun Tan, Thoa Ha, Bruce R. Carr, Paul Nakonezny, Kathleen M. Doody, Kevin J. Doody

Published in: Journal of Assisted Reproduction and Genetics | Issue 9/2014

Abstract

Purpose

To determine whether postwashed total progressively motile sperm count (TPMSC) obtained by CASA estimates could predict positive pregnancy test result in non-donor IUI cycles.

Methods

Six thousand eight hundred and seventy one (6,871) IUI cycles with non-donor semen were retrospectively analyzed. Patient, cycle characteristics and prewashed and postwashed semen parameters were included in analysis. The main outcome measure was the positive pregnancy test result.

Results

The pregnancy rate per cycle (PR/cycle) when postwashed TPMSC is between 0–0.5 million, 0.51–1 million, 1.01–5 million, 5.01–10 million and greater than 10 million were 8.1 % (42/520), 14.4 % (41/285), 16.1 % (237/1,469), 18.4 % (193/1,046) and 18.8 % (668/3,551) respectively. The predicted odd of positive pregnancy result is statistically significantly higher when TPMSC is >0.51 million compared to the TPMSC of <0.51 million (OR = 1.68, 95 % CI: 1.04–2.71). The predicted odd of positive pregnancy result is greatest when TPMSC is at least 5 million (OR = 2, 95 % CI: 1.38 to 2.9).

Conclusion

TPMSC is an independent predictor of pregnancy test result and TPMSC of half million or greater is adequate to achieve statistically similar pregnancy test results after non-donor IUI cycles.

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Title: Predictive value of postwashed total progressively motile sperm count using CASA estimates in 6871 non-donor intrauterine insemination cycles
Authors: Orkun Tan
Thoa Ha
Bruce R. Carr
Paul Nakonezny
Kathleen M. Doody
Kevin J. Doody
Publication date: 01-09-2014
Publisher: Springer US
Published in: Journal of Assisted Reproduction and Genetics / Issue 9/2014
Print ISSN: 1058-0468
Electronic ISSN: 1573-7330
DOI: https://doi.org/10.1007/s10815-014-0306-0

At a glance: The STEP trials

Springer Medicine

Predictive value of postwashed total progressively motile sperm count using CASA estimates in 6871 non-donor intrauterine insemination cycles

Abstract

Purpose

Methods

Results

Conclusion

At a glance: The STEP trials

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

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