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World Journal of Urology

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01-02-2013 | Topic Paper

Predictive tools for clinical decision-making and counseling of patients with upper tract urothelial carcinoma

Authors: Evanguelos Xylinas, Luis Kluth, Sibani Mangal, Morgan Roupret, Pierre I. Karakiewicz, Shahrokh F. Shariat

Published in: World Journal of Urology | Issue 1/2013

Abstract

Background

Upper tract urothelial carcinoma (UTUC) is a rare disease with a highly heterogeneous biologic behavior. Accurate individualized prediction of the behavior of UTUC could help guide personalized clinical decision-making regarding optimal therapy.

Methods

A MEDLINE literature search was performed on UTUC predictive tools. We recorded input variables, prediction form, number of patients used to develop the prediction tools, outcomes being predicted, prediction tool-specific features, predictive accuracy, and whether internal or external validations were performed. Each prediction tool was classified according to the clinical disease state it addressed and the outcome it predicted.

Results

The literature search generated five published tools for UTUC staging and prognostication. None of these prediction tools have undergone external validation yet. Two tools focused on the clinical decision-making regarding conservative management versus radical nephroureterectomy (RNU), lymphadenectomy versus not, and neoadjuvant systemic therapy versus not. Three tools focused on the prognosis after RNU, thereby helping in the decision-making regarding adjuvant systemic chemotherapy.

Conclusions

Management of UTUC is challenging, and there are no high-level data to guide physicians and patients. Prognostic tools relying on data from large cohorts of patients are currently the best source of information for evidence-based management of UTUC patients.

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Title: Predictive tools for clinical decision-making and counseling of patients with upper tract urothelial carcinoma
Authors: Evanguelos Xylinas
Luis Kluth
Sibani Mangal
Morgan Roupret
Pierre I. Karakiewicz
Shahrokh F. Shariat
Publication date: 01-02-2013
Publisher: Springer-Verlag
Published in: World Journal of Urology / Issue 1/2013
Print ISSN: 0724-4983
Electronic ISSN: 1433-8726
DOI: https://doi.org/10.1007/s00345-012-0947-5

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Predictive tools for clinical decision-making and counseling of patients with upper tract urothelial carcinoma

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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