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01-10-2018 | Original Article

Predictive factors affecting the prognosis and late complications of 73 consecutive cases of esophageal atresia at 2 centers

Authors: Ryuta Masuya, Tatsuru Kaji, Motoi Mukai, Kazuhiko Nakame, Takafumi Kawano, Seiro Machigashira, Waka Yamada, Koji Yamada, Shun Onishi, Keisuke Yano, Tomoe Moriguchi, Koshiro Sugita, Masato Kawano, Hiroyuki Noguchi, Masaya Suzuhigashi, Mitsuru Muto, Satoshi Ieiri

Published in: Pediatric Surgery International | Issue 10/2018

Abstract

Purpose

While the diagnosis and outcomes of esophageal atresia (EA) have improved, associated anomalies, the management of late complications and growth remain major issues. We analyzed factors that affected the prognosis, late complications and growth.

Methods

We retrospectively reviewed EA patients treated at two centers from 1984 to 2016. Patient characteristics, complications (gastroesophageal reflux [GER], anastomotic stenosis, tracheomalacia, dysphagia) and growth were evaluated.

Results

Seventy-three EA patients were treated (overall survival rate:80.8%). The mean birth weight was 2514 ± 509 g in the surviving group, and 2453 ± 567 g in the fatal group excluded chromosomal abnormality (p = 0.76). Cardiac and chromosomal anomalies significantly affected mortality. Postoperative GER and anastomotic stenosis each occurred in 39% of the patients. Only GER was significantly affected by the Gross classification. The standard deviation (SD) values of the EA patients’ growth were all lower than in the normal population. The SD of body weight was significantly lower in patients with extremity anomalies.

Conclusions

Associated cardiac and chromosomal anomalies significantly affected the prognosis. GER and anastomotic stenosis were the most common late complications. The growth of the surviving cases was insufficient. These factors will help optimize the therapeutic strategies and postoperative management for EA.

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Title: Predictive factors affecting the prognosis and late complications of 73 consecutive cases of esophageal atresia at 2 centers
Authors: Ryuta Masuya
Tatsuru Kaji
Motoi Mukai
Kazuhiko Nakame
Takafumi Kawano
Seiro Machigashira
Waka Yamada
Koji Yamada
Shun Onishi
Keisuke Yano
Tomoe Moriguchi
Koshiro Sugita
Masato Kawano
Hiroyuki Noguchi
Masaya Suzuhigashi
Mitsuru Muto
Satoshi Ieiri
Publication date: 01-10-2018
Publisher: Springer Berlin Heidelberg
Published in: Pediatric Surgery International / Issue 10/2018
Print ISSN: 0179-0358
Electronic ISSN: 1437-9813
DOI: https://doi.org/10.1007/s00383-018-4326-1

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Predictive factors affecting the prognosis and late complications of 73 consecutive cases of esophageal atresia at 2 centers

Abstract

Purpose

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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