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Supportive Care in Cancer
Published in: Supportive Care in Cancer 10/2020

01-10-2020 | Original Article

Predictive clinical factors of chronic peripheral neuropathy induced by oxaliplatin

Authors: Nilgun Yildirim, Mahir Cengiz

Published in: Supportive Care in Cancer | Issue 10/2020

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Abstract

Purpose

We aimed to identify potential clinical parameters that can be easily obtained by a pre-treatment clinicopathological evaluation and whole blood test to estimate the development of oxaliplatin-induced peripheral neuropathy (OIPN).

Methods

This study was conducted retrospectively. For the FOLFOX regimen, patients received oxaliplatin, 85 mg/m2, every 2 weeks for 12 courses, and with the XELOX regimen, oxaliplatin was 130 mg/m2, every 3 weeks for 6–8 courses. The incidence and degree of neuropathy (NCI-CTCAE v.3) were recorded.

Results

A total of 186 patients were included in the study. There were 108 (58%) patients in the grade 0–1 (G0–G1) neuropathy group (mean age 50.5 ± 11.5; 63% men), and 78 (42%) patients in the grade 2–3 (G2–G3) neuropathy group (mean age 58.0 ± 10.8; 46.2% men). The relationship between G2–G3 OIPN development and age (p < 0.001), gender (p = 0.02), and ECOG performance status (p = 0.007) was statistically significant. In the G2–G3 neuropathy group, serum gamma-glutamyl transferase (GGT) (p < 0.001) and glucose (p = 0.007) levels were higher, whereas vitamin D (p < 0.001), hemoglobin (Hgb) (p < 0.001), serum albumin (p = 0.001), and serum magnesium (p = 0.035) levels were lower compared with the G0–G1 neuropathy group. G2–G3 neuropathy was observed in 88% of patients with mucinous carcinoma pathologic type (p < 0.001).

Conclusion

This study demonstrated that age, histopathologic type, albumin, GGT, glucose, vitamin D, and Hgb levels were the effective factors in prediction of the development of OIPN. In addition, GGT, vitamin D, and Hgb levels were the most effective factor to predict development of OIPN.
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Metadata
Title
Predictive clinical factors of chronic peripheral neuropathy induced by oxaliplatin
Authors
Nilgun Yildirim
Mahir Cengiz
Publication date
01-10-2020
Publisher
Springer Berlin Heidelberg
Published in
Supportive Care in Cancer / Issue 10/2020
Print ISSN: 0941-4355
Electronic ISSN: 1433-7339
DOI
https://doi.org/10.1007/s00520-020-05319-x

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