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memo - Magazine of European Medical Oncology
Published in: memo - Magazine of European Medical Oncology 1/2015

01-04-2015 | review

Predicting drug sensitivity by 3D cell culture models

Authors: Arno Amann, MD, Gabriele Gamerith, MD, Julia M. Huber, PhD, Marit Zwierzina, MD, Wolfgang Hilbe, MD, Heinz Zwierzina, MD

Published in: memo - Magazine of European Medical Oncology | Issue 1/2015

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Abstract

Because of recent failures of novel drugs in phase II and III trials innovative in vitro models are needed that may predict drug efficacy in patients. Although, numerous modifications of traditional cell culture and animal models were undertaken significant improvements in cell culture- based drug development have not been achieved. Three-dimensional (3D) cell culture may represents an modern alternative to bridge the gap between 2D cell cultures and animal models.
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Metadata
Title
Predicting drug sensitivity by 3D cell culture models
Authors
Arno Amann, MD
Gabriele Gamerith, MD
Julia M. Huber, PhD
Marit Zwierzina, MD
Wolfgang Hilbe, MD
Heinz Zwierzina, MD
Publication date
01-04-2015
Publisher
Springer Vienna
Published in
memo - Magazine of European Medical Oncology / Issue 1/2015
Print ISSN: 1865-5041
Electronic ISSN: 1865-5076
DOI
https://doi.org/10.1007/s12254-015-0196-6

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