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Open Access 01-04-2011 | Original Article

Precursor lesions of early onset pancreatic cancer

Authors: Łukasz Liszka, Jacek Pająk, Sławomir Mrowiec, Ewa Zielińska-Pająk, Dariusz Gołka, Paweł Lampe

Published in: Virchows Archiv | Issue 4/2011

Abstract

Early onset pancreatic cancer (EOPC) constitutes less than 5% of all newly diagnosed cases of pancreatic cancer (PC). Although histopathological characteristics of EOPC have been described, no detailed reports on precursor lesions of EOPC are available. In the present study, we aimed to describe histopathological picture of extratumoral parenchyma in 23 cases of EOPCs (definition based on the threshold value of 45 years of age) with particular emphasis on two types of precursor lesions of PC: pancreatic intraepithelial neoplasia (PanIN) and intraductal papillary mucinous neoplasms (IPMNs). The types, grades, and densities of precursor lesions of PC were compared in patients with EOPCs, in young patients with neuroendocrine neoplasms (NENs), and in older (at the age of 46 or more) patients with PC. PanINs were found in 95.6% of cases of EOPCs. PanINs-3 were found in 39.1% of EOPC cases. Densities of all PanIN grades in EOPC cases were larger than in young patients with NENs. Density of PanINs-1A in EOPC cases was larger than in older patients with PC, but densities of PanINs of other grades were comparable. IPMN was found only in a single patient with EOPC but in 20% of older patients with PC. PanINs are the most prevalent precursor lesions of EOPC. IPMNs are rarely precursor lesions of EOPC. Relatively high density of low-grade PanINs-1 in extratumoral parenchyma of patients with EOPC may result from unknown multifocal genetic alterations in pancreatic tissue in patients with EOPCs.

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Title: Precursor lesions of early onset pancreatic cancer
Authors: Łukasz Liszka
Jacek Pająk
Sławomir Mrowiec
Ewa Zielińska-Pająk
Dariusz Gołka
Paweł Lampe
Publication date: 01-04-2011
Publisher: Springer-Verlag
Published in: Virchows Archiv / Issue 4/2011
Print ISSN: 0945-6317
Electronic ISSN: 1432-2307
DOI: https://doi.org/10.1007/s00428-011-1056-3

At a glance: The STEP trials

Springer Medicine

Precursor lesions of early onset pancreatic cancer

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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