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Published in: Archives of Gynecology and Obstetrics 3/2015

01-09-2015 | Review

Pre-eclampsia during pregnancy and cardiovascular disease later in life: the case for a risk group

Author: Ragnar Rylander

Published in: Archives of Gynecology and Obstetrics | Issue 3/2015

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Abstract

Introduction

Women with pre-eclampsia (PE) have an increased risk of cardiovascular disease (CVD) later in life. This association might reflect an effect of pre-eclampsia on mechanisms inducing a higher risk of CVD or the presence of a group at risk.

Materials and methods

The possibility that women with a magnesium deficiency might constitute a risk group was examined using published evidence form investigations on PE and CVD.

Results

Available data strongly suggest that a magnesium deficiency is a major risk factor for both PE and for CVD disease later in life.

Conclusions

Magnesium homeostasis studies in women with PE should be undertaken for validation purposes. The results suggest that women with PE should be given dietary counselling to decrease future risks of CVD.
Literature
1.
go back to reference Roccella EJ (2000) Report of the national high blood pressure education program working group on high blood pressure in pregnancy. Am J Obstet Gynecol 183:S1–S22 Roccella EJ (2000) Report of the national high blood pressure education program working group on high blood pressure in pregnancy. Am J Obstet Gynecol 183:S1–S22
2.
go back to reference Backes, CH, Markham K, Moorehead P, Cordero L, Nankervis CA, Giannone PJ (2011) Maternal preeclampsia and neonatal outcomes. J Pregnancy, article ID 214365 Backes, CH, Markham K, Moorehead P, Cordero L, Nankervis CA, Giannone PJ (2011) Maternal preeclampsia and neonatal outcomes. J Pregnancy, article ID 214365
3.
4.
go back to reference Bellamy L, Casas J-P, Hingorani AD, Williams DJ (2007) Pre-eclampsia and risk of cardiovascular disease and cancer in later life: systematic review and meta-analysis. Br Med J 335:974–986CrossRef Bellamy L, Casas J-P, Hingorani AD, Williams DJ (2007) Pre-eclampsia and risk of cardiovascular disease and cancer in later life: systematic review and meta-analysis. Br Med J 335:974–986CrossRef
5.
go back to reference Wikström A-K, Haglund B, Olovsson M, Nordén Lindeberg S (2005) The risk of maternal ischaemic heart disease after gestational hypertensive disease. BJOG 112:1486–1491PubMedCrossRef Wikström A-K, Haglund B, Olovsson M, Nordén Lindeberg S (2005) The risk of maternal ischaemic heart disease after gestational hypertensive disease. BJOG 112:1486–1491PubMedCrossRef
6.
go back to reference Staff AC, Dechend R, Redman CWG (2013) Review: preeclampsia, acute atherosis of the spiral arteries, and future cardiovascular disease: two new hypotheses. Placenta 34. Supplement A. Trophoblast Res 27:S73–S78 Staff AC, Dechend R, Redman CWG (2013) Review: preeclampsia, acute atherosis of the spiral arteries, and future cardiovascular disease: two new hypotheses. Placenta 34. Supplement A. Trophoblast Res 27:S73–S78
7.
go back to reference Romundstad PR, Magnussen EB, Smith GD, Vatten LJ (2010) Hypertension in pregnancy and later cardiovascular risk—common antecedents? Circulation 122:579–684PubMedCrossRef Romundstad PR, Magnussen EB, Smith GD, Vatten LJ (2010) Hypertension in pregnancy and later cardiovascular risk—common antecedents? Circulation 122:579–684PubMedCrossRef
8.
go back to reference Rylander R, Tallheden T, Vormann J (2009) Acid-base conditions regulate calcium and magnesium homeostasis. Magnes Res 22:1–4 Rylander R, Tallheden T, Vormann J (2009) Acid-base conditions regulate calcium and magnesium homeostasis. Magnes Res 22:1–4
9.
go back to reference Franz KB (1987) Magnesium intake during pregnancy. Magnesium 6:18–27PubMed Franz KB (1987) Magnesium intake during pregnancy. Magnesium 6:18–27PubMed
10.
go back to reference Spätling L, Kunz PA, Huch R, Huch A (1985) Magnesium and calcium excretion during pregnancy. Mag Bull 3:91–93 Spätling L, Kunz PA, Huch R, Huch A (1985) Magnesium and calcium excretion during pregnancy. Mag Bull 3:91–93
11.
go back to reference Rylander R (2014) Magnesium in pregnancy blood pressure and pre-eclampsia—a review. Pregn Hypertens 4:146–149 Rylander R (2014) Magnesium in pregnancy blood pressure and pre-eclampsia—a review. Pregn Hypertens 4:146–149
12.
go back to reference Nestler A, Rylander R, Kolisek M, Nielsen T, Ödman N, Vormann J, Bullarbo M (2014) Blood pressure in pregnancy and magnesium sensitive genes. Pregnancy Hypertens 41:41–45 Nestler A, Rylander R, Kolisek M, Nielsen T, Ödman N, Vormann J, Bullarbo M (2014) Blood pressure in pregnancy and magnesium sensitive genes. Pregnancy Hypertens 41:41–45
13.
go back to reference Nielsen TF, Rylander R (2011) Urinary calcium and magnesium excretion relates to increased blood pressure during pregnancy. Arch Gynecol Obstet 283:443–447PubMedCrossRef Nielsen TF, Rylander R (2011) Urinary calcium and magnesium excretion relates to increased blood pressure during pregnancy. Arch Gynecol Obstet 283:443–447PubMedCrossRef
14.
go back to reference Bandebuche S, Sagade B, Sontakke A (2013) Serum magnesium in pregnancy induced hypertension. Int J Res Med Sci 1:413–416CrossRef Bandebuche S, Sagade B, Sontakke A (2013) Serum magnesium in pregnancy induced hypertension. Int J Res Med Sci 1:413–416CrossRef
15.
go back to reference Kisters K, Körner J, Louwen F, Witteler R, Jackisch C, Zidek W et al (1998) Plasma and membrane Ca2+ and Mg2+ concentrations in normal pregnancy and in preeclampsia. Gynecol Obstet Invest 46:158–163PubMedCrossRef Kisters K, Körner J, Louwen F, Witteler R, Jackisch C, Zidek W et al (1998) Plasma and membrane Ca2+ and Mg2+ concentrations in normal pregnancy and in preeclampsia. Gynecol Obstet Invest 46:158–163PubMedCrossRef
16.
go back to reference Resnick LM, Barbagallo M, Bardicef M, Bardicef O, Sorokin Y, Evelhoch J et al (2004) Cellular-free magnesium depletion in brain and muscle of normal and preeclamptic pregnancy: a nuclear magnetic resonance spectroscopic study. Hypertension 44:322–326PubMedCrossRef Resnick LM, Barbagallo M, Bardicef M, Bardicef O, Sorokin Y, Evelhoch J et al (2004) Cellular-free magnesium depletion in brain and muscle of normal and preeclamptic pregnancy: a nuclear magnetic resonance spectroscopic study. Hypertension 44:322–326PubMedCrossRef
17.
18.
go back to reference Boston JL, Beauchene RE, Cruikshank DP (1989) Erythrocyte and plasma magnesium during teenage pregnancy. Relationship with blood pressure and pregnancy induced hypertension. Obstet Gynecol 73:169–174PubMed Boston JL, Beauchene RE, Cruikshank DP (1989) Erythrocyte and plasma magnesium during teenage pregnancy. Relationship with blood pressure and pregnancy induced hypertension. Obstet Gynecol 73:169–174PubMed
19.
go back to reference Borekei B, Gulaboglu M, Gul M (2009) Iodine and magnesium levels in maternal and umbilical cord blood of preeclamptic and normal pregnant women. Biol Trace Elem Res. doi:10.1007/s12011-008-8278-5 Borekei B, Gulaboglu M, Gul M (2009) Iodine and magnesium levels in maternal and umbilical cord blood of preeclamptic and normal pregnant women. Biol Trace Elem Res. doi:10.​1007/​s12011-008-8278-5
20.
go back to reference Jain S, Sharma P, Kulshreshtha S et al (2010) The role of calcium, magnesium, and zink in pre-eclampsia. Biol Trace Elem Res 133:162–170PubMedCrossRef Jain S, Sharma P, Kulshreshtha S et al (2010) The role of calcium, magnesium, and zink in pre-eclampsia. Biol Trace Elem Res 133:162–170PubMedCrossRef
21.
go back to reference Del Gobbo LC, Imamura F, Wu JHY, de Oliviera Otto MC, Chiuve SE (2013) Circulating and dietary magnesium and risk of cardiovascular disease: a systematic review and meta-analysis of prospective studies. Am J Clin Nutr 98:160–173PubMedCentralPubMedCrossRef Del Gobbo LC, Imamura F, Wu JHY, de Oliviera Otto MC, Chiuve SE (2013) Circulating and dietary magnesium and risk of cardiovascular disease: a systematic review and meta-analysis of prospective studies. Am J Clin Nutr 98:160–173PubMedCentralPubMedCrossRef
22.
go back to reference Zhang W, Iso H, Ohira T, Date C, Tamakoshi A (2012) JACC study group. Associations of dietary magnesium intake and mortality from cardiovascular disease: the JACC study. Atherosclerosis 221:587–595PubMedCrossRef Zhang W, Iso H, Ohira T, Date C, Tamakoshi A (2012) JACC study group. Associations of dietary magnesium intake and mortality from cardiovascular disease: the JACC study. Atherosclerosis 221:587–595PubMedCrossRef
23.
go back to reference Ascherio A, Rimm EB, Hernán MA, Giovannucci GL, Kawachi I, Stampfer MJ, Willett WC (1998) Intake of potassium, magnesium, calcium, and fiber and risk of stroke among US men. Circulation 98:1198–1204PubMedCrossRef Ascherio A, Rimm EB, Hernán MA, Giovannucci GL, Kawachi I, Stampfer MJ, Willett WC (1998) Intake of potassium, magnesium, calcium, and fiber and risk of stroke among US men. Circulation 98:1198–1204PubMedCrossRef
24.
go back to reference Chiuve SE, Sun Q, Curhan GC, Taylor EN, Spiegelman D, Willet WC, Manson JE, Rexrode KM, Albert CM (2013) Dietary and plasma magnesium and risk of coronary heart disease among women. J Am Heart Ass 2:e000114. doi:10.1161/JAHA.113.000114 Chiuve SE, Sun Q, Curhan GC, Taylor EN, Spiegelman D, Willet WC, Manson JE, Rexrode KM, Albert CM (2013) Dietary and plasma magnesium and risk of coronary heart disease among women. J Am Heart Ass 2:e000114. doi:10.​1161/​JAHA.​113.​000114
Metadata
Title
Pre-eclampsia during pregnancy and cardiovascular disease later in life: the case for a risk group
Author
Ragnar Rylander
Publication date
01-09-2015
Publisher
Springer Berlin Heidelberg
Published in
Archives of Gynecology and Obstetrics / Issue 3/2015
Print ISSN: 0932-0067
Electronic ISSN: 1432-0711
DOI
https://doi.org/10.1007/s00404-015-3676-3

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