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Journal of Cardiovascular Magnetic Resonance

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Open Access 01-12-2012 | Oral presentation

PPACK and Bivalirudin nanoparticles enable simultaneous imaging and potent inhibition of acute clotting

Authors: Jacob W Myerson, John S Allen, Todd A Williams, Li He, Douglas M Tollefsen, Gregory Lanza, Shelton D Caruthers, Samuel A Wickline

Published in: Journal of Cardiovascular Magnetic Resonance | Special Issue 1/2012

Excerpt

Perfluorocarbon nanoparticles functionalized for thombin inhibition with Bivalirudin or PPACK were tested as an inhibitor of thrombin in vitro and in acute thrombosis models. The particles significantly inhibited occlusive arterial thrombi. The particles also manifested binding providing magnetic resonance contrast highlighting thrombi. …

Title: PPACK and Bivalirudin nanoparticles enable simultaneous imaging and potent inhibition of acute clotting
Authors: Jacob W Myerson
John S Allen
Todd A Williams
Li He
Douglas M Tollefsen
Gregory Lanza
Shelton D Caruthers
Samuel A Wickline
Publication date: 01-12-2012
Publisher: BioMed Central
Published in: Journal of Cardiovascular Magnetic Resonance / Issue Special Issue 1/2012
Electronic ISSN: 1532-429X
DOI: https://doi.org/10.1186/1532-429X-14-S1-O41

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PPACK and Bivalirudin nanoparticles enable simultaneous imaging and potent inhibition of acute clotting

Excerpt

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Excerpt

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