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01-07-2011 | Review Article

Potential feasibility of dental stem cells for regenerative therapies: stem cell transplantation and whole-tooth engineering

Author: Taka Nakahara

Published in: Odontology | Issue 2/2011

Abstract

Multipotent mesenchymal stem cells from bone marrow are expected to be a somatic stem cell source for the development of new cell-based therapy in regenerative medicine. However, dental clinicians are unlikely to carry out autologous cell/tissue collection from patients (i.e., marrow aspiration) as a routine procedure in their clinics; hence, the utilization of bone marrow stem cells seems impractical in the dental field. Dental tissues harvested from extracted human teeth are well known to contain highly proliferative and multipotent stem cell compartments and are considered to be an alternative autologous cell source in cell-based medicine. This article provides a short overview of the ongoing studies for the potential application of dental stem cells and suggests the utilization of 2 concepts in future regenerative medicine: (1) dental stem cell-based therapy for hepatic and other systemic diseases and (2) tooth replacement therapy using the bioengineered human whole tooth, called the “test-tube dental implant.” Regenerative therapies will bring new insights and benefits to the fields of clinical medicine and dentistry.

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Title: Potential feasibility of dental stem cells for regenerative therapies: stem cell transplantation and whole-tooth engineering
Author: Taka Nakahara
Publication date: 01-07-2011
Publisher: Springer Japan
Published in: Odontology / Issue 2/2011
Print ISSN: 1618-1247
Electronic ISSN: 1618-1255
DOI: https://doi.org/10.1007/s10266-011-0037-y

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Potential feasibility of dental stem cells for regenerative therapies: stem cell transplantation and whole-tooth engineering

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