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Documenta Ophthalmologica
Published in: Documenta Ophthalmologica 1/2010

01-02-2010 | Review Article

Postnatal hyperoxia and the developing rat retina: beyond the obvious vasculopathy

Authors: A. L. Dorfman, S. Chemtob, P. Lachapelle

Published in: Documenta Ophthalmologica | Issue 1/2010

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Abstract

Although a great deal of emphasis has been placed on the vasculopathy that is associated with oxygen-induced retinopathy (OIR), our studies also revealed significant and irreversible structural (retinal histology) and functional (scotopic and photopic electroretinograms) impairments that were significantly more severe in pigmented Long–Evans rats compared to the more commonly used albino Sprague Dawley rats. In the following pages, we will highlight what we have learned about the retinal pathophysiological processes of OIR taking place in strains of both rats with the hope that this will trigger investigations into new therapeutic strategies to complement those geared at preventing the vasculopathy.
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Metadata
Title
Postnatal hyperoxia and the developing rat retina: beyond the obvious vasculopathy
Authors
A. L. Dorfman
S. Chemtob
P. Lachapelle
Publication date
01-02-2010
Publisher
Springer-Verlag
Published in
Documenta Ophthalmologica / Issue 1/2010
Print ISSN: 0012-4486
Electronic ISSN: 1573-2622
DOI
https://doi.org/10.1007/s10633-009-9208-3

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