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International Ophthalmology

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01-11-2020 | Original Paper

Posterior pole retinal thickness distribution pattern in keratoconus

Authors: Ali Mahdavi Fard, Sangita P. Patel, Raana Daei Sorkhabi, Sara Salekzamani, Elena Pezzino, Nader D. Nader

Published in: International Ophthalmology | Issue 11/2020

Abstract

Purpose

To evaluate the pattern of retinal thickness distribution in patients with keratoconus (KCN) and its correlation with disease severity.

Methods

For this cross-sectional cohort study, the study subjects with documented keratoconus and normal eyes were prospectively enrolled. All subjects had anterior segment (Pentacam HR) and posterior segment (Spectralis) imaging. Posterior segment imaging by optical coherence tomography included the posterior pole asymmetry analysis map. Data were analyzed with multiple linear regression models and correlation tests to examine the mean and variance of the measured thickness of the retina and its distribution relative to the presence and severity of KCN.

Results

A total of 24 subjects with keratoconus (48 eyes) and 14 normal subjects (28 eyes) enrolled in this study. The posterior pole retinal thickness, both superior and inferior hemifields, as well as the overall retinal thickness in KCN patients was greater than the control group. There was a direct correlation between the overall retinal thickness of the posterior pole and the severity of KCN (R² = 0.422, P < 0.001). However, the variability of the retinal thickness showed no difference between KCN-afflicted and healthy eyes.

Conclusion

Although KCN is a disease of the anterior segment of the eye, we found an orderly increase in posterior pole retinal thickness that is correlated with the severity of disease in KCN eyes compared to control. These findings suggest that the retina may maintain some degree of plasticity to respond to the degraded optical system of the eye.

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Title: Posterior pole retinal thickness distribution pattern in keratoconus
Authors: Ali Mahdavi Fard
Sangita P. Patel
Raana Daei Sorkhabi
Sara Salekzamani
Elena Pezzino
Nader D. Nader
Publication date: 01-11-2020
Publisher: Springer Netherlands
Published in: International Ophthalmology / Issue 11/2020
Print ISSN: 0165-5701
Electronic ISSN: 1573-2630
DOI: https://doi.org/10.1007/s10792-020-01464-8

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Springer Medicine

Posterior pole retinal thickness distribution pattern in keratoconus

Abstract

Purpose

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

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