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BMC Psychiatry
Published in: BMC Psychiatry 1/2020

01-12-2020 | Post Traumatic Stress Disorder | Research article

Exploring memory function in earthquake trauma survivors with resting-state fMRI and machine learning

Authors: Yuchen Li, Hongru Zhu, Zhengjia Ren, Su Lui, Minlan Yuan, Qiyong Gong, Cui Yuan, Meng Gao, Changjian Qiu, Wei Zhang

Published in: BMC Psychiatry | Issue 1/2020

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Abstract

Background

Traumatized earthquake survivors may develop poor memory function. Resting-state functional magnetic resonance imaging (rs-fMRI) and machine learning techniques may one day aid the clinical assessment of individual psychiatric patients. This study aims to use machine learning with Rs-fMRI from the perspectives of neurophysiology and neuroimaging to explore the association between it and the individual memory function of trauma survivors.

Methods

Rs-fMRI data was acquired for eighty-nine survivors (male (33%), average age (SD):45.18(6.31) years) of Wenchuan earthquakes in 2008 each of whom was screened by experienced psychiatrists based on the clinician-administered post-traumatic stress disorder (PTSD) scale (CAPS), and their memory function scores were determined by the Wechsler Memory Scale-IV (WMS-IV). We explored which memory function scores were significantly associated with CAPS scores. Using simple multiple kernel learning (MKL), Rs-fMRI was used to predict the memory function scores that were associated with CAPS scores. A support vector machine (SVM) was also used to make classifications in trauma survivors with or without PTSD.

Results

Spatial addition (SA), which is defined by spatial working memory function, was negatively correlated with the total CAPS score (r = − 0.22, P = 0.04). The use of simple MKL allowed quantitative association of SA scores with statistically significant accuracy (correlation = 0.28, P = 0.03; mean squared error = 8.36; P = 0.04). The left middle frontal gyrus and the left precuneus contributed the largest proportion to the simple MKL association frame. The SVM could not make a quantitative classification of diagnosis with statistically significant accuracy.

Limitations

The use of the cross-sectional study design after exposure to an earthquake and the leave-one-out cross-validation (LOOCV) increases the risk of overfitting.

Conclusion

Spontaneous brain activity of the left middle frontal gyrus and the left precuneus acquired by rs-fMRI may be a brain mechanism of visual working memory that is related to PTSD symptoms. Machine learning may be a useful tool in the identification of brain mechanisms of memory impairment in trauma survivors.
Appendix
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Metadata
Title
Exploring memory function in earthquake trauma survivors with resting-state fMRI and machine learning
Authors
Yuchen Li
Hongru Zhu
Zhengjia Ren
Su Lui
Minlan Yuan
Qiyong Gong
Cui Yuan
Meng Gao
Changjian Qiu
Wei Zhang
Publication date
01-12-2020
Publisher
BioMed Central
Published in
BMC Psychiatry / Issue 1/2020
Electronic ISSN: 1471-244X
DOI
https://doi.org/10.1186/s12888-020-2452-5

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