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European Archives of Psychiatry and Clinical Neuroscience

05-04-2024 | Post-COVID Syndrome | Original Paper

Effects of an integrative multimodal inpatient program on fatigue and work ability in patients with Post-COVID Syndrome—a prospective observational study

Authors: Sarah Schmid, Christine Uecker, Antje Fröhlich, Jost Langhorst

Published in: European Archives of Psychiatry and Clinical Neuroscience

Abstract

Post-COVID syndrome (PCS) is characterized by a variety of non-specific symptoms. One of the leading symptoms is fatigue. So far, there is no evidence-based causal therapy established and treatment of PCS is primarily symptom-oriented. The Clinic for Internal and Integrative Medicine in Bamberg, Germany, offers a comprehensive multimodal integrative inpatient therapy for PCS patients. Within a prospective uncontrolled observational study, the results of N = 79 patients were analysed. Post-COVID fatigue patients were hospitalized for up to 14 days. The treatment consists of individual modules depending on the patient’s needs. It includes a wide range of integrative non-pharmacological treatment modalities. Outcomes were assessed before and after the inpatient treatment as well as 6 months after discharge from the hospital. Results show that fatigue of post-COVID patients in this study (M = 76.30, SD = 10.18, N = 64) was initially significantly higher than in the subsample “women aged 60–92 years” of the general German population (M = 51.5, Schwarz et al. [Schwarz et al. in Onkologie 26:140–144, 2003]; T(63) = 19.50, p < .001). Fatigue was significantly and clinically relevant reduced directly after discharge (M_T1 = 76.21, SD = 11.38, N = 42; M_T2 = 66.57, SD = 15.55, N = 42), F(1, 41) = 19.80, p < .001, partial eta squared = .326, as well as six months after discharge (M_T3 = 65.31, SD = 17.20, N = 42), F(1, 41), p < .001, partial eta squared = .371. Additionally, self-reported ability to work (NRS, 0–10) improved significantly from admission (M_T1 = 2.54, SD = 2.23, N = 39) to discharge (M_T2 = 4.26, SD = 2.60, N = 39), F(1, 38) = 26.37, p < .001, partial eta squared = .410), as well as to six months later (M_T3 = 4.41, SD = 3.23, N = 39), F(1, 38) = 15.00, p < .001, partial eta squared = .283. The study showed that patients suffering from chronic post-COVID syndrome for several months can achieve a significant improvement in their leading fatigue symptoms and a significant improvement in the subjective assessment of their ability to work through a comprehensive two-week multimodal integrative inpatient program.

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Title: Effects of an integrative multimodal inpatient program on fatigue and work ability in patients with Post-COVID Syndrome—a prospective observational study
Authors: Sarah Schmid
Christine Uecker
Antje Fröhlich
Jost Langhorst
Publication date: 05-04-2024
Publisher: Springer Berlin Heidelberg
Keywords: Post-COVID Syndrome
Fatigue
Published in: European Archives of Psychiatry and Clinical Neuroscience
Print ISSN: 0940-1334
Electronic ISSN: 1433-8491
DOI: https://doi.org/10.1007/s00406-024-01792-1

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Effects of an integrative multimodal inpatient program on fatigue and work ability in patients with Post-COVID Syndrome—a prospective observational study

Abstract

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Abstract

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