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European Archives of Oto-Rhino-Laryngology

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01-02-2013 | Head and Neck

Possible role of nano-sized particles in chronic tonsillitis and tonsillar carcinoma: a pilot study

Authors: Karol Zeleník, Jana Kukutschová, Jana Dvořáčková, Hana Bielniková, Pavlína Peikertová, Lenka Čábalová, Pavel Komínek

Published in: European Archives of Oto-Rhino-Laryngology | Issue 2/2013

Abstract

This study aimed to evaluate the palatine tonsils of patients with chronic tonsillitis and spinocellular carcinoma to determine the presence of nano-sized particles. Tonsil samples from adult patients with chronic tonsillitis and spinocellular carcinoma of the palatine tonsil were dried and analyzed using a scanning electron microscope with the X-ray microprobe of an energy-dispersive spectroscope. Demographic data and smoking histories were obtained. The principal metals found in almost all tissues analyzed were iron, chromium, nickel, aluminum, zinc, and copper. No significant difference in elemental composition was found between the group of patients with chronic tonsillitis and the group with spinocellular carcinoma of the palatine tonsil. Likewise, no significant difference was found between the group of smokers and the group of nonsmokers. The presence of various micro- and nano-sized metallic particles in human tonsils was confirmed. These particles may potentially cause an inflammatory response as well as neoplastic changes in human palatine tonsils similar to those occurring in the lungs. Further and more detailed studies addressing this issue, including studies designed to determine the chemical form of the metals detected, studies devoted to quantitative analysis, biokinetics, and to the degradation and elimination of nanoparticles are needed for a more detailed prediction of the relation between the diagnosis and the presence of specific metal nanoparticles in tonsillar tissue.

Monteiro-Riviere NA, Tran CL (2007) Nanotoxicology: characterization, dosing and health effects. Informa Healthcare, Inc, New York

Donaldson K, Stone V, Tran CL et al (2004) Nanotoxicology. Occup Environ Med 61:727–728PubMedCrossRef

Oberdörster G, Oberdörster E, Oberdörster J (2005) Nanotoxicology: an emerging discipline evolving from studies of ultrafine particles. Environ Health Perspect 13:823–840CrossRef

Singh S, Nalwa HS (2007) Nanotechnology and health safety—toxicity and risk assessments of nanostructured materials on human health. J Nanosci Nanotechnol 7:3048–3070PubMedCrossRef

HSE (2004) Health effects of particles produced for nanotechnologies. EH75/6 HSE Books 2004

Kukutschová J, Roubíček V, Mašláň M et al (2010) Wear performance and wear debris of semimetallic automotive brake materials. Wear 268:86–93CrossRef

Buonanno G, Morawska L, Stanule L (2009) Particle emission factors during cooking activities. Atmos Environ 43:3235–3242CrossRef

Oberdörster G, Sharp Z, Atudorei V et al (2004) Translocation of inhaled ultrafine particles to the brain. Inhal Toxicol 16:437–445PubMedCrossRef

Elder A, Gelein R, Silva V et al (2006) Translocation of inhaled ultrafine manganese oxide particles to the central nervous system. Environ Health Perspect 114:1172–1178PubMedCrossRef

10.

Geiser M, Rothen-Rutishauser B, Kapp N et al (2005) Ultrafine particles cross cellular membranes by non-phagocytic mechanisms in lungs and in cultured cells. Environ Health Perspect 113:1555–1560PubMedCrossRef

11.

Geiser H, Kreyling WG (2010) Deposition and biokinetics of inhaled nanoparticles. Particle Fibre Toxicol 7:2. doi:10.1186/1743-8977-7-2 CrossRef

12.

Li N, Sioutas C, Cho A et al (2003) Ultrafine particulate pollutants induce oxidative stress and mitochondrial damage. Environ Health Perspect 111:455–460PubMedCrossRef

13.

Singh N, Manshian B, Jenkins GJS et al (2009) NanoGenotoxicology: The DNA damaging potential of engineered nanomaterials. Biomaterials 30:3891–3914PubMedCrossRef

14.

Donaldson K, Poland CA, Schins RP (2010) Possible genotoxic mechanisms of nanoparticles: criteria for improved test strategies. Nanotoxicology 4:414–420PubMedCrossRef

15.

Oberdörster G (2001) Pulmonary effects of inhaled ultrafine particles. Int Arch Occup Environ Health 74:1–8PubMedCrossRef

16.

Delfino RJ, Sioutas C, Malik S (2005) Potential role of ultrafine particles in associations between airborne particle mass and cardiovascular health. Environ Health Perspect 113:934–946PubMedCrossRef

17.

Antonini JM, Lewis AB, Roberts JR et al (2003) Pulmonary effects of welding fumes: review of worker and experimental animal studies. Am J Ind Med 43:350–360PubMedCrossRef

18.

Shi X, Castranova V, Halliwell B et al (1998) Reactive oxygen species and silica-induced carcinogenesis. J Toxicol Environ Health B Crit Rev 1:181–197PubMedCrossRef

19.

Kazi TG, Jalbani N, Arain MB et al (2009) Toxic metals distribution in different components of Pakistani and imported cigarettes by electrothermal atomic absorption spectrometer. J Hazard Mater 163:302–307PubMedCrossRef

20.

Kukutschova J, Roubiček V, Malachova K et al (2009) Wear mechanism in automotive brake materials, wear debris and its potential environmental impact. Wear 267:807–817CrossRef

21.

Iijima A, Sato K, Yano K et al (2007) Particle size and composition distribution analysis of automotive brake abrasion dusts for the evaluation of antimony sources of airborne particulate matter. Atmos Environ 41:4908–4919CrossRef

22.

Councell TB, Duckenfield KU, Landa ER et al (2004) Tire-wear particles as a source of zinc to the environment. Environ Sci Technol 38:4206–4214PubMedCrossRef

23.

Antonini JM, Afshari AA, Stone S et al (2006) Design, construction, and characterization of a novel robotic welding fume generator and inhalation exposure system for laboratory animals. J Occup Environ Hyg 3:194–203PubMedCrossRef

24.

Gibbs BM, Thompson D, Argent BB (2008) Mobilisation of trace elements from as-supplied and additionally cleaned coal: predictions for Ba, Be, Cd, Co., Mo, Nb, Sb, V and W. Fuel 87:1217–1229CrossRef

Title: Possible role of nano-sized particles in chronic tonsillitis and tonsillar carcinoma: a pilot study
Authors: Karol Zeleník
Jana Kukutschová
Jana Dvořáčková
Hana Bielniková
Pavlína Peikertová
Lenka Čábalová
Pavel Komínek
Publication date: 01-02-2013
Publisher: Springer-Verlag
Published in: European Archives of Oto-Rhino-Laryngology / Issue 2/2013
Print ISSN: 0937-4477
Electronic ISSN: 1434-4726
DOI: https://doi.org/10.1007/s00405-012-2069-5

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Possible role of nano-sized particles in chronic tonsillitis and tonsillar carcinoma: a pilot study

Abstract

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