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Clinical Rheumatology

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01-05-2022 | Positron Emission Tomography | Original Article

The value of 68 Ga-PSMA-11 positron emission tomography/computerized tomography in evaluating the lacrimal and salivary glands function

Authors: Jian-fang Li, Lu-ping Qin, Qing-yu Wu, Xing-hua Guo, Jie-zheng Yang, Qi-chang Wan, Mu-hua Cheng, Liang-jun Xie

Published in: Clinical Rheumatology | Issue 5/2022

Abstract

Objective

To investigate the value of ⁶⁸ Ga-PSMA-11 positron emission tomography/computerized tomography (PET/CT) in evaluating lacrimal and salivary glands function.

Methods

Ten patients with pSS and 18 healthy volunteers were recruited in this study. All participants underwent ⁶⁸ Ga-PSMA-11 PET/CT, and the patients with pSS performed salivary gland scintigraphy the next day. The maximum standardized uptake value (SUVmax), average of the standard uptake value (SUVavg), the average CT value (CTavg), and volume (V) in the region of interest (ROI) of each lacrimal and salivary gland were analyzed in⁶⁸Ga-PSMA-11 PET/CT. The uptake ratio (UR) of the bilateral parotid gland and submandibular gland was calculated in salivary gland scintigraphy (SGS). Statistical analysis was processed by the SPSS software and the MedCalc software. A p-value of < 0.05 was considered as statistically significant.

Results

Almost all the parameters of pSS were significantly lower than those of the control group (p < 0.05). The left parotid gland (PG) UR was positive correlation with left PG SUVmax (r = 0.758, p = 0.011) and left PG SUVavg (r = 0.770, p = 0.009); the right PGUR was positive correlation with right PG SUVmax (r = 0.721, p = 0.019) and right PG SUVavg (r = 0.721, p = 0.019). The SUVmax and SUVavg of both sides of acrimal and salivary glands had area under the receiver operating curve values greater than 0.5.

Conclusions

⁶⁸ Ga-PSMA-11 PET/CT can simultaneously enable the visualization of lacrimal glands and salivary glands and be used to evaluate the lacrimal and salivary glands function.

Key Points

• We have firstly investigated the value of 68 Ga-PSMA-11 PET/CT in evaluating lacrimal and salivary glands function in patients with pSS 68 Ga-PSMA-11 PET/CT can simultaneously allow the visualization of lacrimal glands and salivary glands.

• The results of the present study imply that 68 Ga-PSMA-11 PET/CT can be used to evaluate the lacrimal and salivary glands function in patients with pSS meanwhile.

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Title: The value of 68 Ga-PSMA-11 positron emission tomography/computerized tomography in evaluating the lacrimal and salivary glands function
Authors: Jian-fang Li
Lu-ping Qin
Qing-yu Wu
Xing-hua Guo
Jie-zheng Yang
Qi-chang Wan
Mu-hua Cheng
Liang-jun Xie
Publication date: 01-05-2022
Publisher: Springer International Publishing
Keyword: Positron Emission Tomography
Published in: Clinical Rheumatology / Issue 5/2022
Print ISSN: 0770-3198
Electronic ISSN: 1434-9949
DOI: https://doi.org/10.1007/s10067-021-06038-2

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