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European Journal of Nuclear Medicine and Molecular Imaging

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Open Access 19-03-2022 | Positron Emission Tomography | Short Communication

Spatiotemporal dynamics of brain function during the natural course in a dental pulp injury model

Authors: Feiyan Yu, Miao Li, Qianqian Wang, Jing Wang, Shuang Wu, Rui Zhou, Han Jiang, Xiaoyi Li, Yu Zhou, Xi Yang, Xiao He, Yan Cheng, Xiuyun Ren, Hong Zhang, Mei Tian

Published in: European Journal of Nuclear Medicine and Molecular Imaging | Issue 8/2022

Abstract

Purpose

Toothache, a common disorder afflicting most people, shows distinct features at different clinical stages. This study aimed to depict metabolic changes in brain and investigate the potential mechanism involved in the aberrant affective behaviors during the natural process of toothache.

Methods

We investigated the spatiotemporal patterns of brain function during the natural course of toothache in a rat model of dental pulp injury (DPI) by using positron emission tomography (PET).

Results

Glucose metabolism peaked on the 3rd day and gradually decreased in several brain regions after DPI, which was in line with the behavioral and histological results. PET imaging showed that visual pathway was involved in the regulation of toothache. Meanwhile, the process of emotional regulation underlying toothache was mediated by N-methyl-D-aspartic receptor subunit 2B (NR2B) in the caudal anterior cingulate cortex (cACC).

Conclusion

Our results revealed the spatiotemporal neurofunctional patterns during toothache process and preliminarily elucidated the role of NR2B in cACC in the regulation of toothache-related affective behaviors.

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Title: Spatiotemporal dynamics of brain function during the natural course in a dental pulp injury model
Authors: Feiyan Yu
Miao Li
Qianqian Wang
Jing Wang
Shuang Wu
Rui Zhou
Han Jiang
Xiaoyi Li
Yu Zhou
Xi Yang
Xiao He
Yan Cheng
Xiuyun Ren
Hong Zhang
Mei Tian
Publication date: 19-03-2022
Publisher: Springer Berlin Heidelberg
Keyword: Positron Emission Tomography
Published in: European Journal of Nuclear Medicine and Molecular Imaging / Issue 8/2022
Print ISSN: 1619-7070
Electronic ISSN: 1619-7089
DOI: https://doi.org/10.1007/s00259-022-05764-2

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Spatiotemporal dynamics of brain function during the natural course in a dental pulp injury model

Abstract

Purpose

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

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