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Open Access 01-11-2019 | Positron Emission Tomography | Original Article

Mapping the landscape of human dopamine D2/3 receptors with [¹¹C]raclopride

Authors: Goran Papenberg, Lars Jonasson, Nina Karalija, Jarkko Johansson, Ylva Köhncke, Alireza Salami, Micael Andersson, Jan Axelsson, Anders Wåhlin, Katrine Riklund, Ulman Lindenberger, Martin Lövdén, Lars Nyberg, Lars Bäckman

Published in: Brain Structure and Function | Issue 8/2019

Abstract

The dopamine D2/3 system is fundamental for sensory, motor, emotional, and cognitive aspects of behavior. Small-scale human histopathological and animal studies show high density of D2/3 dopamine receptors (D2/3DR) in striatum, but also demonstrate the existence of such receptors across cortical and limbic regions. Assessment of D2/3DR BP_ND in the extrastriatal regions with [¹¹C]raclopride has long been considered unreliable due to the relatively low density of D2/3DR outside the striatum. We describe the distribution and interregional links of D2/3DR availability measured with PET and [¹¹C]raclopride across the human brain in a large sample (N = 176; age range 64–68 years). Structural equation modeling revealed that D2/3DR availability can be organized according to anatomical (nigrostriatal, mesolimbic, mesocortical) and functional (limbic, associative, sensorimotor) dopamine pathways. D2/3DR availability in corticolimbic functional subdivisions showed differential associations to corresponding striatal subdivisions, extending animal and pharmacological work. Our findings provide evidence on the dimensionality and organization of [¹¹C]raclopride D2/3DR availability in the living human brain that conforms to known dopaminergic pathways.

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Title: Mapping the landscape of human dopamine D2/3 receptors with [11C]raclopride
Authors: Goran Papenberg
Lars Jonasson
Nina Karalija
Jarkko Johansson
Ylva Köhncke
Alireza Salami
Micael Andersson
Jan Axelsson
Anders Wåhlin
Katrine Riklund
Ulman Lindenberger
Martin Lövdén
Lars Nyberg
Lars Bäckman
Publication date: 01-11-2019
Publisher: Springer Berlin Heidelberg
Keyword: Positron Emission Tomography
Published in: Brain Structure and Function / Issue 8/2019
Print ISSN: 1863-2653
Electronic ISSN: 1863-2661
DOI: https://doi.org/10.1007/s00429-019-01938-1

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Mapping the landscape of human dopamine D2/3 receptors with [¹¹C]raclopride

Abstract

Keynote webinar | Spotlight on medication adherence

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Abstract

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