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01-07-2020 | Positron Emission Tomography | Original Article

Association between human gray matter metabotropic glutamate receptor-5 availability in vivo and white matter properties: a [¹¹C]ABP688 PET and diffusion tensor imaging study

Authors: Song E. Kim, Yo-Han Joo, Young-Don Son, Hang-Keun Kim, Sang-Yoon Lee, Min-Woo Lee, Tatsuo Ido, Jong-Hoon Kim

Published in: Brain Structure and Function | Issue 6/2020

Abstract

Excitatory corticofugal projections in the subcortical white matter (WM) convey signals arising from local neuronal activity in the gray matter (GM). We hypothesized that metabotropic glutamate receptor-5 (mGluR5) availability in GM, as a surrogate marker for local glutamatergic neuronal activity, correlates with WM properties in healthy brain. We examined the relationship in healthy individuals between GM mGluR5 availability measured in vivo using [¹¹C]ABP688 positron emission tomography (PET) and WM properties measured as fractional anisotropy (FA) using diffusion tensor imaging (DTI). Twenty-three healthy volunteers underwent this multimodal imaging. We calculated mGluR5 availability, [¹¹C]ABP688 binding potential (BP_ND), using the simplified reference tissue model, and generated DTI FA maps using FMRIB’s Diffusion Toolbox (FDT) along with Tract-Based Spatial Statistics (TBSS). To investigate the relationship between mGluR5 availability and FA, we performed voxel-wise and region of interest (ROI)-based analyses. The voxel-wise analysis showed significant positive correlations between the whole cerebral GM [¹¹C]ABP688 BP_ND and the FA in widespread WM regions including the corpus callosum body, internal capsule, and corona radiata (FWE corrected p < 0.05). The ROI-based analysis also revealed significant positive correlations (Bonferroni-corrected threshold p < 0.00021) between [¹¹C]ABP688 BP_ND in the frontal and parietal cortical GM and FA in the internal capsule (anterior limb and retrolenticular part). Using a novel multimodal imaging interrogation, we provide the first evidence that GM mGluR5 availability is significantly positively associated with WM properties in healthy subjects. Future comparison studies could determine whether this relationship is perturbed in neuropsychiatric disorders with dysregulated mGluR5 signaling.

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Title: Association between human gray matter metabotropic glutamate receptor-5 availability in vivo and white matter properties: a [11C]ABP688 PET and diffusion tensor imaging study
Authors: Song E. Kim
Yo-Han Joo
Young-Don Son
Hang-Keun Kim
Sang-Yoon Lee
Min-Woo Lee
Tatsuo Ido
Jong-Hoon Kim
Publication date: 01-07-2020
Publisher: Springer Berlin Heidelberg
Keyword: Positron Emission Tomography
Published in: Brain Structure and Function / Issue 6/2020
Print ISSN: 1863-2653
Electronic ISSN: 1863-2661
DOI: https://doi.org/10.1007/s00429-020-02094-7

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Association between human gray matter metabotropic glutamate receptor-5 availability in vivo and white matter properties: a [¹¹C]ABP688 PET and diffusion tensor imaging study

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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