Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.
ADVANCED SEARCH
Log in
Top
Radiation Oncology
Published in: Radiation Oncology 1/2016

Open Access 01-12-2016 | Research

Portfolio of prospective clinical trials including brachytherapy: an analysis of the ClinicalTrials.gov database

Authors: Nikola Cihoric, Alexandros Tsikkinis, Cristina Gutierrez Miguelez, Vratislav Strnad, Ivan Soldatovic, Pirus Ghadjar, Branislav Jeremic, Alan Dal Pra, Daniel M. Aebersold, Kristina Lössl

Published in: Radiation Oncology | Issue 1/2016

Login to get access

Abstract

Background

To evaluate the current status of prospective interventional clinical trials that includes brachytherapy (BT) procedures.

Methods

The records of 175,538 (100 %) clinical trials registered at ClinicalTrials.gov were downloaded on September 2014 and a database was established. Trials using BT as an intervention were identified for further analyses. The selected trials were manually categorized according to indication(s), BT source, applied dose rate, primary sponsor type, location, protocol initiator and funding source. We analyzed trials across 8 available trial protocol elements registered within the database.

Results

In total 245 clinical trials were identified, 147 with BT as primary investigated treatment modality and 98 that included BT as an optional treatment component or as part of the standard treatment. Academic centers were the most frequent protocol initiators in trials where BT was the primary investigational treatment modality (p < 0.01). High dose rate (HDR) BT was the most frequently investigated type of BT dose rate (46.3 %) followed by low dose rate (LDR) (42.0 %). Prostate was the most frequently investigated tumor entity in trials with BT as the primary treatment modality (40.1 %) followed by breast cancer (17.0 %). BT was rarely the primary investigated treatment modality for cervical cancer (6.8 %).

Conclusion

Most clinical trials using BT are predominantly in early phases, investigator-initiated and with low accrual numbers. Current investigational activities that include BT mainly focus on prostate and breast cancers. Important questions concerning the optimal usage of BT will not be answered in the near future.
Appendix
Available only for authorised users
Literature
1.
2.
Delaney G, Jacob S, Featherstone C, Barton M. The role of radiotherapy in cancer treatment: estimating optimal utilization from a review of evidence-based clinical guidelines. Cancer. 2005;104(6):1129–37.CrossRefPubMed
3.
Gerbaulet A. The GEC ESTRO handbook of brachytherapy. Brussels: Estro; 2002.
4.
Veldeman L, Madani I, Hulstaert F, De Meerleer G, Mareel M, De Neve W. Evidence behind use of intensity-modulated radiotherapy: a systematic review of comparative clinical studies. Lancet Oncol. 2008;9(4):367–75.CrossRefPubMed
5.
Zarin DA, Tse T. Clarification about ClinicalTrials.gov. Irb. 2013;35(3):19.PubMed
6.
7.
De Angelis CD, Drazen JM, Frizelle FA, Haug C, Hoey J, Horton R, Kotzin S, Laine C, Marusic A, Overbeke AJ, et al. Is this clinical trial fully registered? a statement from the international committee of medical journal editors. Ann Intern Med. 2005;143(2):146–8.CrossRefPubMed
8.
Palma DA, Zietman A. Clinical trial registration: a mandatory requirement for publication in the red journal. Int J Radiat Oncol Biol Phys. 2015;91(4):685–6.CrossRef
9.
Gillen JE, Tse T, Ide NC, McCray AT. Design, implementation and management of a web-based data entry system for ClinicalTrials.gov. Stud Health Technol Inform. 2004;107(Pt 2):1466–70.PubMed
10.
11.
Cihoric N, Tsikkinis A, van Rhoon G, Crezee H, Aebersold DM, Bodis S, Beck M, Nadobny J, Budach V, Wust P, et al. Hyperthermia-related clinical trials on cancer treatment within the ClinicalTrials.gov registry. Int J Hyperthermia. 2015. doi:10.​3109/​02656736.​2015.​1040471.PubMed
12.
Hill KD, Chiswell K, Califf RM, Pearson G, Li JS. Characteristics of pediatric cardiovascular clinical trials registered on ClinicalTrials.gov. Am Heart J. 2014;167(6):921–9. e922.CrossRefPubMedPubMedCentral
13.
Subherwal S, Patel MR, Chiswell K, Tidemann-Miller BA, Jones WS, Conte MS, White CJ, Bhatt DL, Laird JR, Hiatt WR, et al. Clinical trials in peripheral vascular disease: pipeline and trial designs: an evaluation of the ClinicalTrials.gov database. Circulation. 2014;130(20):1812–9.CrossRefPubMedPubMedCentral
14.
Subramanian J, Regenbogen T, Nagaraj G, Lane A, Devarakonda S, Zhou G, Govindan R. Review of ongoing clinical trials in non-small-cell lung cancer: a status report for 2012 from the ClinicalTrials.gov Web site. J Thorac Oncol. 2013;8(7):860–5.CrossRefPubMed
15.
16.
Califf RM, Zarin DA, Kramer JM, Sherman RE, Aberle LH, Tasneem A. Characteristics of clinical trials registered in ClinicalTrials.gov, 2007–2010. Jama. 2012;307(17):1838–47.CrossRefPubMed
17.
Hirsch BR, Califf RM, Cheng SK, Tasneem A, Horton J, Chiswell K, Schulman KA, Dilts DM, Abernethy AP. Characteristics of oncology clinical trials: insights from a systematic analysis of ClinicalTrials.gov. JAMA Intern Med. 2013;173(11):972–9.CrossRefPubMed
18.
Guedea F, Ellison T, Venselaar J, Borras JM, Hoskin P, Poetter R, Heeren G, Nisin R, Francois G, Mazeron JJ, et al. Overview of brachytherapy resources in Europe: a survey of patterns of care study for brachytherapy in Europe. Radiother Oncol. 2007;82(1):50–4.CrossRefPubMed
19.
Guedea F, Venselaar J, Hoskin P, Hellebust TP, Peiffert D, Londres B, Ventura M, Mazeron JJ, Limbergen EV, Potter R, et al. Patterns of care for brachytherapy in Europe: updated results. Radiother Oncol. 2010;97(3):514–20.CrossRefPubMed
20.
Thompson SR, Delaney GP, Gabriel GS, Barton MB. Patterns of care study of brachytherapy in New South Wales: cervical cancer treatment quality depends on caseload. J Contemp Brachytherapy. 2014;6(1):28–32.CrossRefPubMedPubMedCentral
21.
Guedea F, Ventura M, Londres B, Pinillos L, Poitevin A, Ospino R, Cordova A, Camacho R, Britton R, Sarria G, et al. Overview of brachytherapy resources in Latin America: a patterns-of-care survey. Brachytherapy. 2011;10(5):363–8.CrossRefPubMed
22.
Mitchell JM. Urologists’ use of intensity-modulated radiation therapy for prostate cancer. N Engl J Med. 2013;369(17):1629–37.CrossRefPubMed
23.
Teshima T, Numasaki H, Shibuya H, Nishio M, Ikeda H, Sekiguchi K, Kamikonya N, Koizumi M, Tago M, Ando Y, et al. Japanese structure survey of radiation oncology in 2007 based on institutional stratification of patterns of care study. Int J Radiat Oncol Biol Phys. 2010;78(5):1483–93.CrossRefPubMed
24.
AlDuhaiby EZ, Breen S, Bissonnette JP, Sharpe M, Mayhew L, Tyldesley S, Wilke DR, Hodgson DC. A national survey of the availability of intensity-modulated radiation therapy and stereotactic radiosurgery in Canada. Radiat Oncol. 2012;7:18.CrossRefPubMedPubMedCentral
25.
Han K, Milosevic M, Fyles A, Pintilie M, Viswanathan AN. Trends in the utilization of brachytherapy in cervical cancer in the United States. Int J Radiat Oncol Biol Phys. 2013;87(1):111–9.CrossRefPubMed
26.
Thompson SR, Delaney GP, Gabriel GS, Jacob S, Barton MB. Estimation of the optimal brachytherapy utilisation rate in the treatment of vaginal cancer and comparison with patterns of care. J Med Imaging Radiat Oncol. 2012;56(4):483–9.CrossRefPubMed
27.
Moses 3rd H, Matheson DH, Cairns-Smith S, George BP, Palisch C, Dorsey ER. The anatomy of medical research: US and international comparisons. Jama. 2015;313(2):174–89.CrossRefPubMed
28.
29.
Becker JE, Ross JS. Reporting discrepancies between the clinicaltrials.gov results database and peer-reviewed publications. Ann Intern Med. 2014;161(10):760.CrossRefPubMed
30.
Riveros C, Dechartres A, Perrodeau E, Haneef R, Boutron I, Ravaud P. Timing and completeness of trial results posted at ClinicalTrials.gov and published in journals. PLoS Med. 2013;10(12), e1001566.CrossRefPubMedPubMedCentral
31.
Erickson B, Eifel P, Moughan J, Rownd J, Iarocci T, Owen J. Patterns of brachytherapy practice for patients with carcinoma of the cervix (1996–1999): a patterns of care study. Int J Radiat Oncol Biol Phys. 2005;63(4):1083–92.CrossRefPubMed
32.
Potter R, Dimopoulos J, Georg P, Lang S, Waldhausl C, Wachter-Gerstner N, Weitmann H, Reinthaller A, Knocke TH, Wachter S, et al. Clinical impact of MRI assisted dose volume adaptation and dose escalation in brachytherapy of locally advanced cervix cancer. Radiother Oncol. 2007;83(2):148–55.CrossRefPubMed
33.
Haie-Meder C, Chargari C, Rey A, Dumas I, Morice P, Magne N. DVH parameters and outcome for patients with early-stage cervical cancer treated with preoperative MRI-based low dose rate brachytherapy followed by surgery. Radiother Oncol. 2009;93(2):316–21.CrossRefPubMed
34.
Narayan K, van Dyk S, Bernshaw D, Rajasooriyar C, Kondalsamy-Chennakesavan S. Comparative study of LDR (Manchester system) and HDR image-guided conformal brachytherapy of cervical cancer: patterns of failure, late complications, and survival. Int J Radiat Oncol Biol Phys. 2009;74(5):1529–35.CrossRefPubMed
35.
Chargari C, Magne N, Dumas I, Messai T, Vicenzi L, Gillion N, Morice P, Haie-Meder C. Physics contributions and clinical outcome with 3D-MRI-based pulsed-dose-rate intracavitary brachytherapy in cervical cancer patients. Int J Radiat Oncol Biol Phys. 2009;74(1):133–9.CrossRefPubMed
36.
Mahantshetty U, Khanna N, Swamidas J, Engineer R, Thakur MH, Merchant NH, Deshpande DD, Shrivastava S. Trans-abdominal ultrasound (US) and magnetic resonance imaging (MRI) correlation for conformal intracavitary brachytherapy in carcinoma of the uterine cervix. Radiother Oncol. 2012;102(1):130–4.CrossRefPubMed
37.
Kirchheiner K, Nout R, Lindegaard J, Petric P, Limbergen EV, Jurgenliemk-Schulz IM, Haie-Meder C, Potter R, Dorr W. Do clinicians and patients agree regarding symptoms? a comparison after definitive radiochemotherapy in 223 uterine cervical cancer patients. Strahlenther Onkol. 2012;188(10):933–9.CrossRefPubMed
38.
Kirchheiner K, Nout RA, Tanderup K, Lindegaard JC, Westerveld H, Haie-Meder C, Petric P, Mahantshetty U, Dorr W, Potter R. Manifestation pattern of early-late vaginal morbidity after definitive radiation (chemo)therapy and image-guided adaptive brachytherapy for locally advanced cervical cancer: an analysis from the EMBRACE study. Int J Radiat Oncol Biol Phys. 2014;89(1):88–95.CrossRefPubMed
39.
Nkiwane KS, Pötter R, Tanderup K, Federico M, Lindegaard JC, Kirisits C. Single line source with and without vaginal loading and the impact on target coverage and organ at risk doses for cervix cancer Stages IB, II, and IIIB: Treatment planning simulation in patients treated with MRI-guided adaptive brachytherapy in a multicentre study (EMBRACE). Brachytherapy. 2013;12(4):317–23.CrossRefPubMed
40.
Kirchheiner K, Nout RA, Czajka-Pepl A, Ponocny-Seliger E, Sturdza AE, Dimopoulos JC, et al. Health related quality of life and patient reported symptoms before and during definitive radio(chemo)therapy using image-guided adaptive brachytherapy for locally advanced cervical cancer and early recovery - A mono-institutional prospective study. Gynecol Oncol. 2014.
41.
Cihoric N, Tapia C, Kruger K, Aebersold DM, Klaeser B, Lossl K. IMRT with (1)(8)FDG-PET\CT based simultaneous integrated boost for treatment of nodal positive cervical cancer. Radiat Oncol. 2014;9:83.CrossRefPubMedPubMedCentral
42.
Boyle J, Craciunescu O, Steffey B, Cai J, Chino J. Methods, safety, and early clinical outcomes of dose escalation using simultaneous integrated and sequential boosts in patients with locally advanced gynecologic malignancies. Gynecol Oncol. 2014;135(2):239–43.CrossRefPubMed
43.
Creasman WT, Odicino F, Maisonneuve P, Beller U, Benedet JL, Heintz AP, Ngan HY, Sideri M, Pecorelli S. Carcinoma of the corpus uteri. J Epidemiol Biostat. 2001;6(1):47–86.PubMed
44.
Klopp A, Smith BD, Alektiar K, Cabrera A, Damato AL, Erickson B, Fleming G, Gaffney D, Greven K, Lu K, et al. The role of postoperative radiation therapy for endometrial cancer: Executive summary of an American Society for Radiation Oncology evidence-based guideline. Pract Radiat Oncol. 2014;4(3):137–44.CrossRefPubMed
45.
Sorbe B, Nordström B, Mäenpää J, Kuhelj J, Kuhelj D, Okkan S, Delaloye JF, Frankendal B. Intravaginal brachytherapy in FIGO stage I low-risk endometrial cancer: a controlled randomized study. Int J Gynecol Cancer. 2009;19(5):873–8.CrossRefPubMed
46.
Creutzberg CL, van Putten WL, Koper PC, Lybeert ML, Jobsen JJ, Wárlám-Rodenhuis CC, De Winter KA, Lutgens LC, van den Bergh AC, van de Steen-Banasik E, et al. Surgery and postoperative radiotherapy versus surgery alone for patients with stage-1 endometrial carcinoma: multicentre randomised trial. PORTEC Study Group. Post Operative Radiation Therapy in Endometrial Carcinoma. Lancet. 2000;355(9213):1404–11.CrossRefPubMed
47.
Sorbe B, Horvath G, Andersson H, Boman K, Lundgren C, Pettersson B. External pelvic and vaginal irradiation versus vaginal irradiation alone as postoperative therapy in medium-risk endometrial carcinoma--a prospective randomized study. Int J Radiat Oncol Biol Phys. 2012;82(3):1249–55.CrossRefPubMed
48.
McMeekin DS, Filiaci VL, Aghajanian C, Cho J, Kim JW, DiSilvestro PA, et al. Randomized phase III trial of pelvic radiation therapy (PXRT) versus vaginal cuff brachytherapy followed by paclitaxel/carboplatin chemotherapy (VCB/C) in patients with high risk (HR), early stage endometrial cancer (EC): a Gynecologic Oncology Group trial, Meeting of the society of gynecologic oncology. Tampa: Elsevier; 2014. p. 134–438.
49.
Creutzberg CL, van Stiphout RG, Nout RA, Lutgens LC, Jurgenliemk-Schulz IM, Jobsen JJ, Smit VT, Lambin P. Nomograms for prediction of outcome with or without adjuvant radiation therapy for patients with endometrial cancer: a pooled analysis of PORTEC-1 and PORTEC-2 trials. Int J Radiat Oncol Biol Phys. 2015;91(3):530–9.CrossRefPubMed
50.
Rossi PJ, Jani AB, Horowitz IR, Johnstone PA. Adjuvant brachytherapy removes survival disadvantage of local disease extension in stage IIIC endometrial cancer: a SEER registry analysis. Int J Radiat Oncol Biol Phys. 2008;70(1):134–8.CrossRefPubMed
51.
Ott OJ, Potter R, Hammer J, Hildebrandt G, Lotter M, Resch A, Pohls U, Beckmann MW, Sauer R, Strnad V. Accelerated partial breast irradiation with iridium-192 multicatheter PDR/HDR brachytherapy. Preliminary results of the German-Austrian multicenter trial. Strahlenther Onkol. 2004;180(10):642–9.CrossRefPubMed
52.
Strnad V, Ott O, Potter R, Hildebrandt G, Hammer J, Resch A, Lotter M, Ackermann S, Beckmann MW, Sauer R. Interstitial brachytherapy alone after breast conserving surgery: interim results of a German-Austrian multicenter phase II trial. Brachytherapy. 2004;3(3):115–9.CrossRefPubMed
53.
Ott OJ, Potter R, Hildebrandt G, Hammer J, Lotter M, Beckmann MW, Sauer R, Strnad V. [Partial breast irradiation for early breast cancer with favorable prognostic factors: 3-year results of the German-Austrian phase II-trial]. Röfo. 2005;177(7):962–7.PubMed
54.
Hattangadi JA, Powell SN, MacDonald SM, Mauceri T, Ancukiewicz M, Freer P, Lawenda B, Alm El-Din MA, Gadd MA, Smith BL, et al. Accelerated partial breast irradiation with low-dose-rate interstitial implant brachytherapy after wide local excision: 12-year outcomes from a prospective trial. Int J Radiat Oncol Biol Phys. 2012;83(3):791–800.CrossRefPubMedPubMedCentral
55.
Lawenda BD, Taghian AG, Kachnic LA, Hamdi H, Smith BL, Gadd MA, Mauceri T, Powell SN. Dose-volume analysis of radiotherapy for T1N0 invasive breast cancer treated by local excision and partial breast irradiation by low-dose-rate interstitial implant. Int J Radiat Oncol Biol Phys. 2003;56(3):671–80.CrossRefPubMed
56.
Croshaw R, Kim Y, Lappinen E, Julian T, Trombetta M. Avoiding mastectomy: accelerated partial breast irradiation for breast cancer patients with pacemakers or defibrillators. Ann Surg Oncol. 2011;18(12):3500–5.CrossRefPubMed
57.
Hasan Y, Kim L, Wloch J, Chi Y, Liang J, Martinez A, Yan D, Vicini F. Comparison of planned versus actual dose delivered for external beam accelerated partial breast irradiation using cone-beam CT and deformable registration. Int J Radiat Oncol Biol Phys. 2011;80(5):1473–6.CrossRefPubMed
58.
Jain AK, Vallow LA, Gale AA, Buskirk SJ. Does three-dimensional external beam partial breast irradiation spare lung tissue compared with standard whole breast irradiation? Int J Radiat Oncol Biol Phys. 2009;75(1):82–8.CrossRefPubMed
59.
Strnad V, Ott OJ, Hildebrandt G, Kauer-Dorner D, Knauerhase H, Major T, Lyczek J, Guinot JL, Dunst J, Gutierrez Miguelez C. et al. 5-year results of accelerated partial breast irradiation using sole interstitial multicatheter brachytherapy versus whole-breast irradiation with boost after breast-conserving surgery for low-risk invasive and in-situ carcinoma of the female breast: a randomised, phase 3, non-inferiority trial. Lancet. 2016;387(10015):229–38.CrossRefPubMed
60.
Knauerhase H, Strietzel M, Gerber B, Reimer T, Fietkau R. Tumor location, interval between surgery and radiotherapy, and boost technique influence local control after breast-conserving surgery and radiation: retrospective analysis of monoinstitutional long-term results. Int J Radiat Oncol Biol Phys. 2008;72(4):1048–55.CrossRefPubMed
61.
Grimm P, Billiet I, Bostwick D, Dicker AP, Frank S, Immerzeel J, Keyes M, Kupelian P, Lee WR, Machtens S, et al. Comparative analysis of prostate-specific antigen free survival outcomes for patients with low, intermediate and high risk prostate cancer treatment by radical therapy. Results from the Prostate Cancer Results Study Group. BJU Int. 2012;109 Suppl 1:22–9.CrossRefPubMed
62.
Sylvester JE, Grimm PD, Wong J, Galbreath RW, Merrick G, Blasko JC. Fifteen-year biochemical relapse-free survival, cause-specific survival, and overall survival following I(125) prostate brachytherapy in clinically localized prostate cancer: Seattle experience. Int J Radiat Oncol Biol Phys. 2011;81(2):376–81.CrossRefPubMed
63.
Sylvester JE, Grimm PD, Blasko JC, Millar J, Orio PF, Skoglund S, Galbreath RW, Merrick G. 15-Year biochemical relapse free survival in clinical Stage T1-T3 prostate cancer following combined external beam radiotherapy and brachytherapy; Seattle experience. Int J Radiat Oncol Biol Phys. 2007;67(1):57–64.CrossRefPubMed
64.
Martinez AA, Demanes J, Vargas C, Schour L, Ghilezan M, Gustafson GS. High-dose-rate prostate brachytherapy: an excellent accelerated-hypofractionated treatment for favorable prostate cancer. Am J Clin Oncol. 2010;33(5):481–8.CrossRefPubMed
65.
Tselis N, Tunn UW, Chatzikonstantinou G, Milickovic N, Baltas D, Ratka M, Zamboglou N. High dose rate brachytherapy as monotherapy for localised prostate cancer: a hypofractionated two-implant approach in 351 consecutive patients. Radiat Oncol. 2013;8:115.CrossRefPubMedPubMedCentral
66.
Ghadjar P, Oesch SL, Rentsch CA, Isaak B, Cihoric N, Manser P, Thalmann GN, Aebersold DM. Late toxicity and five year outcomes after high-dose-rate brachytherapy as a monotherapy for localized prostate cancer. Radiat Oncol. 2014;9:122.CrossRefPubMedPubMedCentral
67.
Galalae RM, Martinez A, Mate T, Mitchell C, Edmundson G, Nuernberg N, Eulau S, Gustafson G, Gribble M, Kovács G. Long-term outcome by risk factors using conformal high-dose-rate brachytherapy (HDR-BT) boost with or without neoadjuvant androgen suppression for localized prostate cancer. Int J Radiat Oncol Biol Phys. 2004;58(4):1048–55.CrossRefPubMed
68.
Vargas CE, Martinez AA, Boike TP, Spencer W, Goldstein N, Gustafson GS, Krauss DJ, Gonzalez J. High-dose irradiation for prostate cancer via a high-dose-rate brachytherapy boost: results of a phase I to II study. Int J Radiat Oncol Biol Phys. 2006;66(2):416–23.CrossRefPubMed
69.
Kovács G, Cosset JM, Carey B. Focal radiotherapy as focal therapy of prostate cancer. Curr Opin Urol. 2014;24(3):231–5.CrossRefPubMed
70.
Cosset JM, Cathelineau X, Wakil G, Pierrat N, Quenzer O, Prapotnich D, Barret E, Rozet F, Galiano M, Vallancien G. Focal brachytherapy for selected low-risk prostate cancers: a pilot study. Brachytherapy. 2013;12(4):331–7.CrossRefPubMed
71.
Tsikkinis A, Cihoric N, Giannarini G, Hinz S, Briganti A, Wust P, Ost P, Ploussard G, Massard C, Surcel C, et al. Clinical perspectives from Randomized Phase 3 trials on Prostate Cancer: An Analysis of the Clinicaltrials.gov Database. Euro Urology Focus. 2015. doi:10.​1016/​j.​euf.​2015.​05.​003.
72.
Mahmood U, Pugh T, Frank S, Levy L, Walker G, Haque W, Koshy M, Graber W, Swanson D, Hoffman K, et al. Declining use of brachytherapy for the treatment of prostate cancer. Brachytherapy. 2014;13(2):157–62.CrossRefPubMed
73.
Minsky BD, Pajak TF, Ginsberg RJ, Pisansky TM, Martenson J, Komaki R, Okawara G, Rosenthal SA, Kelsen DP. INT 0123 (Radiation Therapy Oncology Group 94–05) phase III trial of combined-modality therapy for esophageal cancer: high-dose versus standard-dose radiation therapy. J Clin Oncol. 2002;20(5):1167–74.CrossRefPubMed
74.
Oppedijk V, van der Gaast A, van Lanschot JJ, van Hagen P, van Os R, van Rij CM, van der Sangen MJ, Beukema JC, Rütten H, Spruit PH, et al. Patterns of recurrence after surgery alone versus preoperative chemoradiotherapy and surgery in the CROSS trials. J Clin Oncol. 2014;32(5):385–91.CrossRefPubMed
75.
Gao XS, Qiao X, Wu F, Cao L, Meng X, Dong Z, Wang X, Gao G, Wu TT, Komaki R, et al. Pathological analysis of clinical target volume margin for radiotherapy in patients with esophageal and gastroesophageal junction carcinoma. Int J Radiat Oncol Biol Phys. 2007;67(2):389–96.CrossRefPubMed
76.
Okawa T, Dokiya T, Nishio M, Hishikawa Y, Morita K. Multi-institutional randomized trial of external radiotherapy with and without intraluminal brachytherapy for esophageal cancer in Japan. Japanese Society of Therapeutic Radiology and Oncology (JASTRO) Study Group. Int J Radiat Oncol Biol Phys. 1999;45(3):623–8.CrossRefPubMed
77.
Brunner TB, Rupp A, Melzner W, Grabenbauer GG, Sauer R. Esophageal cancer. A prospective phase II study of concomitant-boost external-beam chemoradiation with a top-up endoluminal boost. Strahlenther Onkol. 2008;184(1):15–22.CrossRefPubMed
78.
Vastardis I, Pajic B, Greiner RH, Pajic-Eggspuehler B, Aebersold DM. Prospective study of exclusive strontium-/yttrium-90 beta-irradiation of primary and recurrent pterygia with no prior surgical excision. Clinical outcome of long-term follow-up. Strahlenther Onkol. 2009;185(12):808–14.CrossRefPubMed
79.
Vapiwala N, Moghanaki D, Movsas B. Cultivating tomorrow’s clinician scientists: We reap what we sow. Int J Radiat Oncol Biol Phys. 2015;92(2):206–10.CrossRefPubMed
Metadata
Title
Portfolio of prospective clinical trials including brachytherapy: an analysis of the ClinicalTrials.gov database
Authors
Nikola Cihoric
Alexandros Tsikkinis
Cristina Gutierrez Miguelez
Vratislav Strnad
Ivan Soldatovic
Pirus Ghadjar
Branislav Jeremic
Alan Dal Pra
Daniel M. Aebersold
Kristina Lössl
Publication date
01-12-2016
Publisher
BioMed Central
Published in
Radiation Oncology / Issue 1/2016
Electronic ISSN: 1748-717X
DOI
https://doi.org/10.1186/s13014-016-0624-8

Other articles of this Issue 1/2016

Radiation Oncology 1/2016 Go to the issue

Research

Carbon ion therapy (C12) for high-grade malignant salivary gland tumors (MSGTs) of the head and neck: do non-ACCs profit from dose escalation?

Erratum

Erratum to: Low-dose brachytherapy for early stage penile cancer: a 20-year single-institution study (73 patients)

Research

A Nomogram to predict parotid gland overdose in head and neck IMRT

Research

Acute toxicity in comprehensive head and neck radiation for nasopharynx and paranasal sinus cancers: cohort comparison of 3D conformal proton therapy and intensity modulated radiation therapy

Research

Potential risk factors for jaw osteoradionecrosis after radiotherapy for head and neck cancer

Methodology

Total body irradiation with volumetric modulated arc therapy: Dosimetric data and first clinical experience