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CardioVascular and Interventional Radiology

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01-05-2017 | Clinical Investigation

Portal Vein Embolization with Contralateral Application of Stem Cells Facilitates Increase of Future Liver Remnant Volume in Patients with Liver Metastases

Authors: Jaroslav Ludvík, Petr Duras, Vladislav Třeška, Táňa Matoušková, Jan Brůha, Jakub Fichtl, Daniel Lysák, Jiří Ferda, Jan Baxa

Published in: CardioVascular and Interventional Radiology | Issue 5/2017

Abstract

Objectives

This study aimed to evaluate the progress of future liver remnant volume (FLRV) in patients with liver metastases after portal vein embolization (PVE) with the application of hematopoietic stem cells (HSCs) and compare it with a patients control group after PVE only.

Methods

Twenty patients (group 1) underwent PVE with contralateral HSC application. Subsequently, CT volumetry with the determination of FLRV was performed at weekly intervals, in total three weeks. A sample of twenty patients (group 2) who underwent PVE without HSC application was used as a control group.

Results

The mean of FLRV increased by 173.2 mL during three weeks after the PVE/HSC procedure, whereas by 98.9 mL after PVE only (p = 0.015). Furthermore, the mean daily growth of FLRV by 7.6 mL in group 1 was significantly higher in comparison with 4.1 mL in group 2 (p = 0.007).

Conclusions

PVE with the application of HSC significantly facilitates growth of FLRV in comparison with PVE only. This method could be one of the new suitable approaches to increase the resectability of liver tumours.

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Title: Portal Vein Embolization with Contralateral Application of Stem Cells Facilitates Increase of Future Liver Remnant Volume in Patients with Liver Metastases
Authors: Jaroslav Ludvík
Petr Duras
Vladislav Třeška
Táňa Matoušková
Jan Brůha
Jakub Fichtl
Daniel Lysák
Jiří Ferda
Jan Baxa
Publication date: 01-05-2017
Publisher: Springer US
Published in: CardioVascular and Interventional Radiology / Issue 5/2017
Print ISSN: 0174-1551
Electronic ISSN: 1432-086X
DOI: https://doi.org/10.1007/s00270-017-1566-8

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Portal Vein Embolization with Contralateral Application of Stem Cells Facilitates Increase of Future Liver Remnant Volume in Patients with Liver Metastases

Abstract

Objectives

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Objectives

Methods

Results

Conclusions

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