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01-07-2012 | Original Article

Polymorphisms in the human ALOX12 and ALOX15 genes are associated with peak bone mineral density in Chinese nuclear families

Authors: W.-J. Xiao, Y.-H. Ke, J.-W. He, H. Zhang, J.-B. Yu, W.-W. Hu, J.-M. Gu, G. Gao, H. Yue, C. Wang, Y.-Q. Hu, M. Li, Y.-J. Liu, W.-Z. Fu, Z.-L. Zhang

Published in: Osteoporosis International | Issue 7/2012

Abstract

Summary

Association between ten single-nucleotide polymorphisms (SNPs) in the human ALOX12 and ALOX15 genes and variations in peak bone mineral density (BMD) in a large sample of Chinese nuclear families with female offspring using the quantitative transmission disequilibrium test (QTDT). Our results suggest that the genetic polymorphisms in both human ALOX12 and ALOX15 may contribute to variations in the peak BMD of Chinese women.

Introduction

The aim of this study was to investigate whether polymorphisms in the human ALOX12 and ALOX15 genes are associated with variations in peak BMD in Chinese nuclear families with female offspring.

Methods

Each five SNPs in the ALOX12 and ALOX15 genes were genotyped in a total of 1,260 individuals from 401 Chinese nuclear families. The BMD of the lumbar spine, femoral neck and total hip was measured by dual-energy X-ray absorptiometry. We tested whether a single SNP or a haplotype was associated with peak BMD variations using the QTDT.

Results

Using QTDT to measure within-family associations in ALOX15, we observed a significant association between rs916055 and BMD in the lumbar spine (p = 0.027 in the permutation 1,000 test). However, in ALOX12, rs312470 was significantly associated with BMD in the femoral neck (p = 0.029 and p = 0.036 in the permutation 1,000 test). The results of a haplotype analysis supported the findings of the single locus test for ALOX15.

Conclusions

Our results suggest that the genetic polymorphisms in both human ALOX12 and ALOX15 may contribute to variations in the peak BMD of Chinese women.

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Title: Polymorphisms in the human ALOX12 and ALOX15 genes are associated with peak bone mineral density in Chinese nuclear families
Authors: W.-J. Xiao
Y.-H. Ke
J.-W. He
H. Zhang
J.-B. Yu
W.-W. Hu
J.-M. Gu
G. Gao
H. Yue
C. Wang
Y.-Q. Hu
M. Li
Y.-J. Liu
W.-Z. Fu
Z.-L. Zhang
Publication date: 01-07-2012
Publisher: Springer-Verlag
Published in: Osteoporosis International / Issue 7/2012
Print ISSN: 0937-941X
Electronic ISSN: 1433-2965
DOI: https://doi.org/10.1007/s00198-011-1835-3

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Polymorphisms in the human ALOX12 and ALOX15 genes are associated with peak bone mineral density in Chinese nuclear families

Abstract

Summary

Introduction

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Summary

Introduction

Methods

Results

Conclusions

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