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Cancer Chemotherapy and Pharmacology

Published in:

01-04-2017 | Review Article

Polymeric micelles as mighty nanocarriers for cancer gene therapy: a review

Authors: Mahsa Yousefpour Marzbali, Ahmad Yari Khosroushahi

Published in: Cancer Chemotherapy and Pharmacology | Issue 4/2017

Abstract

Purpose

Gene therapy has shown extensive potential to treat human diseases occurring from the defection of genes like various types of cancers. The cationic polymers, as non-viral gene carriers, offer the ability to engineer carrier systems having customized features that can be adapted to suit any system. Upon polymeric micelle systems’ core–shell structure, micelles can create the capacity to load genes/gene-drugs into the different micelle compartments, respectively.

Methods

The search will be managed in Pubmed, Medline, Cochrane library, Embase and Proquest for articles related to polymeric micelle-based gene delivery in order to cancer gene therapy using the accommodative search terms. A database of the first search of all search engines results will be made and repeated articles will be removed. After that, the related articles will be selected, and also the references of selected articles will be searched in order to find any other articles to complete the search database.

Results

This study reviews kinds of polymeric nanomicelles, which have been used in gene therapy, critical parameters for micelle-based gene delivery, challenges and advantages/disadvantages as well as biosafety of nanomicelles in gene delivery systems. Furthermore, the discussion has focused on stimuli-responsive polymers and strategy and mechanisms regarding tumor-selective gene delivery.

Conclusions

This study provides an overview of the advantages/disadvantages of polymeric-based nanocarriers for cancer gene therapy.

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Title: Polymeric micelles as mighty nanocarriers for cancer gene therapy: a review
Authors: Mahsa Yousefpour Marzbali
Ahmad Yari Khosroushahi
Publication date: 01-04-2017
Publisher: Springer Berlin Heidelberg
Published in: Cancer Chemotherapy and Pharmacology / Issue 4/2017
Print ISSN: 0344-5704
Electronic ISSN: 1432-0843
DOI: https://doi.org/10.1007/s00280-017-3273-1

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Other articles of this Issue 4/2017

In vitro and in vivo evaluation of dasatinib and imatinib on physiological parameters of pulmonary arterial hypertension

The role of circulating tumor cells in evaluation of prognosis and treatment response in advanced non-small-cell lung cancer

XPG genetic polymorphisms and clinical outcome of patients with advanced non-small cell lung cancer under platinum-based treatment: a meta-analysis of 12 studies

Prognostic impact of normalization of serum tumor markers following neoadjuvant chemotherapy in patients with borderline resectable pancreatic carcinoma with arterial contact

Reply: Methotrexate neurotoxicity due to drug interactions: an inadequate folinic acid effect

A phase 1 study of gemcitabine/nab-paclitaxel/S-1 (GAS) combination neoadjuvant chemotherapy for patients with locally advanced pancreatic adenocarcinoma

Keynote webinar | Spotlight on antibody–drug conjugates in cancer