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International Urology and Nephrology
Published in: International Urology and Nephrology 1/2013

01-02-2013 | Nephrology - Translational Section

Podocytes proliferate: novel mechanism identified in collapsing glomerulopathies

Authors: Cheng Zhu, Peter R. Mertens

Published in: International Urology and Nephrology | Issue 1/2013

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Excerpt

For a long time common view was that adult podocytes do not renew themselves. With the discovery of podocytes fulfilling stem cell functions within the glomeruli, this view has been challenged [1, 2]. In a recent report, collapsing focal segmental glomerulosclerosis (FSGS), for example, HIV-associated nephropathy (HIVAN), and idiopathic focal segmental glomerulosclerosis have been utilized as model diseases to elucidate a novel mechanism of podocyte dedifferentiation and renewal. Prof. Artandi’s research group at the Stanford University School of Medicine revealed the involvement of telomerase reverse transcriptase (TERT) and Wnt signaling in controlling reversible podocyte proliferation and dedifferentiation [3]. These findings may have profound consequences on the common view of potentially successful therapeutic strategies, given that the proliferative response commonly observed in collapsing glomerulopathies may be successfully reversed by inhibition of telomerase activities and Wnt signaling. Conversely, a regenerative response may be elicited in other glomerular diseases with podocytopenia by activating these pathways. …
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Metadata
Title
Podocytes proliferate: novel mechanism identified in collapsing glomerulopathies
Authors
Cheng Zhu
Peter R. Mertens
Publication date
01-02-2013
Publisher
Springer Netherlands
Published in
International Urology and Nephrology / Issue 1/2013
Print ISSN: 0301-1623
Electronic ISSN: 1573-2584
DOI
https://doi.org/10.1007/s11255-012-0318-6

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