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Journal of Cancer Research and Clinical Oncology
Published in: Journal of Cancer Research and Clinical Oncology 9/2021

01-09-2021 | Pneumonia | Review – Clinical Oncology

Effectiveness of low-dose radiation therapy to improve mortality of COVID-19

Author: Hamid Ghaznavi

Published in: Journal of Cancer Research and Clinical Oncology | Issue 9/2021

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Abstract

Introduction

Performing low-dose radiation therapy (LDRT) is a new approach to treat pneumonia resulting from COVID-19 disease. This paper aims to evaluate the effectiveness of LDRT in treating COVID-19 patients.

Methods

Medline was searched for “low-dose” and “radiation therapy” and “COVID-19” and “pneumonia” and “inflammation”, to retrieve papers that published on low-dose radiation therapy to improve mortality of COVID-19 patients. Only clinical investigations that included original and case report papers were selected for this paper.

Results

The completed clinical trials that have performed LDRT to treat COVID-19 showed that the effectiveness of LDRT in treating COVID-19 was up to 90%.

Conclusion

The vast majority of primary and secondary outcomes of clinical trial investigations regarding LDRT in treating COVID-19 found that LDRT can be considered a feasible treatment to improve mortality of COVID-19 patients.
Literature
Ameri A, Rahnama N, Bozorgmehr R, Mokhtari M, Farahbakhsh M, Nabavi M et al (2020) Low-dose whole-lung irradiation for COVID-19 pneumonia: short course results. Int J Radiat Oncol Biol Phys 108(5):1134–1139CrossRefPubMedPubMedCentral
Ameri A, Ameri P, Rahnama N, Mokhtari M, Sedaghat M, Hadavand F et al (2021) Low-dose whole-lung irradiation for COVID-19 pneumonia: final results of a pilot study. Int J Radiat Oncol Biol Phys 109(4):859–866CrossRefPubMed
Del Castillo R, Martinez D, Sarria GJ, Pinillos L, Garcia B, Castillo L et al (2020) Low-dose radiotherapy for COVID-19 pneumonia treatment: case report, procedure, and literature review. Strahlenther Onkol 196(12):1086–1093CrossRefPubMedPubMedCentral
Hess CB, Buchwald ZS, Stokes W, Nasti TH, Switchenko JM, Weinberg BD et al (2020) Low-dose whole-lung radiation for COVID-19 pneumonia: planned day 7 interim analysis of a registered clinical trial. Cancer 126(23):5109–5113CrossRefPubMed
Hess CB, Nasti TH, Dhere VR, Kleber TJ, Switchenko JM, Buchwald ZS et al (2021) Immunomodulatory low-dose whole-lung radiation for patients with coronavirus disease 2019-related pneumonia. Int J Radiat Oncol Biol Phys 109(4):867–879CrossRefPubMed
Sanmamed N, Alcantara P, Cerezo E, Gaztañaga M, Cabello N, Gómez S et al (2021) Low-dose radiation therapy in the management of coronavirus disease 2019 (COVID-19) pneumonia (LOWRAD-Cov19): preliminary report. Int J Radiat Oncol Biol Phys 109(4):880–885CrossRefPubMed
Tay MZ, Poh CM, Rénia L, MacAry PA, Ng LF (2020) The trinity of COVID-19: immunity, inflammation and intervention. Nat Rev Immunol 20(6):363–374CrossRefPubMed
Metadata
Title
Effectiveness of low-dose radiation therapy to improve mortality of COVID-19
Author
Hamid Ghaznavi
Publication date
01-09-2021
Publisher
Springer Berlin Heidelberg
Published in
Journal of Cancer Research and Clinical Oncology / Issue 9/2021
Print ISSN: 0171-5216
Electronic ISSN: 1432-1335
DOI
https://doi.org/10.1007/s00432-021-03707-2

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