Top

Published in:

01-01-2010 | Original Paper

Pneumocystis jirovecii pneumonia in a baby with hyper-IgE syndrome

Authors: Ben Zion Garty, Adit Ben-Baruch, Asaf Rolinsky, Cristina Woellner, Bodo Grimbacher, Nufar Marcus

Published in: European Journal of Pediatrics | Issue 1/2010

Abstract

A 4-month-old baby with a family history of hyper-IgE syndrome acquired Pneumocystis jirovecii pneumonia. The patient’s hyper-IgE syndrome score was low, but a genetic study yielded a STAT3 mutation. P. jirovecii pneumonia can be added to the infections associated with hyper-IgE syndrome. In some cases, it may be the presenting manifestation of this immunodeficiency.

Al Soub H, Taha RY, El Deeb Y et al (2004) Pneumocystis carinii pneumonia in a patient without a predisposing illness: case report and review. Scand J Infect Dis 36:618–621. doi:10.1080/00365540410017608 CrossRefPubMed

Freeman AF, Davis J, Anderson VL et al (2006) Pneumocystis jirovecii infection in patients with hyper-immunoglobulin E syndrome. Pediatrics 118:1271–1275. doi:10.1542/peds.2006-0311 CrossRef

Grimbach B, Holland SM, Gallin JI et al (1999) Hyper-IgE syndrome with recurrent infections—an autosomal dominant multisystem disorder. N Engl J Med 340:692–702. doi:10.1056/NEJM199903043400904 CrossRef

Holland SM, Deteo FR, Elloumi HZ et al (2007) STAT3 mutations in the hyper-IgE syndrome. N Engl J Med 357:1608–1619. doi:10.1056/NEJMoa073687 CrossRefPubMed

Kubota M, Takayanagi N, Kurashima K et al (2007) Pneumocystis carinii pneumonia in a patient with hyper-IgE syndrome. Nihon Kokyuki Gakkai Zasshi 45:394–398 JapanesePubMed

Milner JD, Brenchley JM, Laurence A et al (2008) Impaired T(H) 17 cell differentiation in subjects with autosomal dominant hyper-IgE syndrome. Nature 452(7188):773–776. doi:10.1038/nature06764 CrossRefPubMed

Milledge J, Kakakios A, Gillis J et al (2003) Pneumocystis carinii pneumonia as a presenting feature of X-linked hyper-IgM syndrome. J Paediatr Child Health 39:704–706. doi:10.1046/j.1440-1754.2003.00274.x CrossRefPubMed

Mosseri R, Finkelstein Y, Monselize Y et al (2002) Large T-cell lymphoma in a 13-year-old girl with hyperimmunoglobulinemia E syndrome. Pediatr Allergy Immunol 13:143–146. doi:10.1034/j.1399-3038.2002.00088.x CrossRefPubMed

Stiehm ER (2000) Cytokine dysregulation in the hyperimmunoglobulinemia E syndrome. J Pediatr 136:141–142. doi:10.1016/S0022-3476(00)70090-4 CrossRefPubMed

10.

Yilmaz E (2004) Disseminated pulmonary candidiasis complicating hyperimmunoglobulin E (Job’s) syndrome. J Thorac Imaging 19:48–51. doi:10.1097/00005382-200401000-00010 CrossRefPubMed

Title: Pneumocystis jirovecii pneumonia in a baby with hyper-IgE syndrome
Authors: Ben Zion Garty
Adit Ben-Baruch
Asaf Rolinsky
Cristina Woellner
Bodo Grimbacher
Nufar Marcus
Publication date: 01-01-2010
Publisher: Springer-Verlag
Published in: European Journal of Pediatrics / Issue 1/2010
Print ISSN: 0340-6199
Electronic ISSN: 1432-1076
DOI: https://doi.org/10.1007/s00431-009-0973-5

At a glance: The STEP trials

Springer Medicine

Pneumocystis jirovecii pneumonia in a baby with hyper-IgE syndrome

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

Please log in to get access to this content

Other articles of this Issue 1/2010

Caloric intake and weight gain in a neonatal intensive care unit

Helicobacter pylori diagnostic tests in children: review of the literature from 1999 to 2009

Jeune syndrome: description of 13 cases and a proposal for follow-up protocol

Campylobacter jejuni infection associated with myopericarditis in adolescents: report of two cases

Acute kidney injury following hypokalemic rhabdomyolysis: complication of chronic heavy cola consumption in an adolescent boy

Accidental ingestion of dosulepin presenting as atrial flutter in a child