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Diagnostic Pathology
Published in: Diagnostic Pathology 1/2008

Open Access 01-12-2008 | Case Report

Pleomorphic liposarcoma of the foot: a case report

Authors: Luka Brčić, Antonija Jakovčević, Lovorka Batelja Vuletić, Dubravko Orlić, Sven Seiwerth

Published in: Diagnostic Pathology | Issue 1/2008

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Abstract

Background

Liposarcomas are among the most common sarcomas of adult life. Pleomorphic liposarcoma, characterized by pleomorphic lipoblasts, is the rarest subtype. To our knowledge only three cases of pleomorphic liposarcoma of the foot or ankle have been reported so far.

Case presentation

A 71-year-old female presented with a large growing mass on the dorsum of her right foot. Computed tomography showed invasive tumorous mass. Excision biopsy revealed the mass to be a pleomorphic liposarcoma, and below the knee amputation was performed.

Conclusion

Although the incidence of pleomorphic liposarcoma in the foot is very low, it is essential to perform thorough histological analysis of all soft tissue masses, regardless of their benign appearance, because only prompt radical surgery can result in a good prognosis for the patient.
Appendix
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Literature
1.
Fletcher CDM: Soft tissue tumors. Diagnostic Histopathology of Tumors. Edited by: Fletcher CDM. 2000, London: Churchill Livingstone, 1473-1540. 2
2.
Weiss SW, Goldblum JR: Liposarcoma. Enzinger and Weiss's Soft Tissue Tumors. Edited by: Weiss SW, Goldblum JR. 2001, St Louis, MO: Mosby, 641-693. 4
3.
Gebhard S, Coindre JM, Michels JJ, Terrier P, Bertrand G, Trassard M, Taylor S, Château MC, Marquès B, Picot V, Guillou L: Pleomorphic liposarcoma. Clinicopathologic and immunohistochemical study of 63 cases. A study of the French Sarcoma Group. Am J Surg Pathol. 2002, 26: 601-616. 10.1097/00000478-200205000-00006.CrossRefPubMed
4.
Downes KA, Goldblum JR, Montgomery EA, Fisher C: Pleomorphic liposarcoma: a clinicopathological analysis of 19 cases. Mod Pathol. 2001, 14: 179-184. 10.1038/modpathol.3880280.CrossRefPubMed
5.
Hornick JL, Bosenberg MW, Mentzel T, McMenamin ME, Oliveira AM, Fletcher CD: Pleomorphic liposarcoma. Am J Surg Pathol. 2004, 28: 1257-1267. 10.1097/01.pas.0000135524.73447.4a.CrossRefPubMed
6.
Nishimoto S, Matsushita T, Matsumolo K, Adachi S: A rare case of burn scar malignancy. Burns. 1996, 22: 497-499. 10.1016/0305-4179(96)00003-4.CrossRefPubMed
7.
Cai YC, Mc Menamin ME, Rose G, Sandy CJ, Cree IA, Fletcher CD: Primary liposarcoma of the orbit: A clinicopathological study of seven cases. Ann Diagn Pathol. 2001, 5: 255-266. 10.1053/adpa.2001.27911.CrossRefPubMed
8.
Dei Tos AP, Mentzel T, Fletcher CD: Primary liposarcoma of the skin: a rare neoplasm with unusual high grade features. Am J Dermatopathol. 1998, 20: 332-338. 10.1097/00000372-199808000-00002.CrossRefPubMed
9.
Klimstra DS, Moran CA, Perino G, Koss MN, Rosai J: Liposarcoma of the anterior mediastinum and thymus. A clinicopathologic study of 28 cases. Am J Surg Pathol. 1995, 19: 782-791.CrossRefPubMed
10.
Miettinen M, Enzinger FM: Epithelioid variant of pleomorphic liposarcoma: a study of 12 cases of a distinctive variant of high-grade liposarcoma. Mod Pathol. 1999, 12: 722-728.PubMed
11.
Oliveira AM, Nascimento AG: Pleomorphic liposarcoma. Semin Diagn Pathol. 2001, 18: 274-285.PubMed
12.
Sakamoto A, Matono H, Yoshida T, Tanaka K, Matsuda S, Oda Y, Iwamoto Y: Dedifferentiated liposarcoma with leukocytosis. A case report of G-CSF-producing soft tissue tumors, possible association with undifferentiated liposarcoma lineage. World J Surg Oncol. 2007, 5: 131-10.1186/1477-7819-5-131.PubMedCentralCrossRefPubMed
13.
Mentzel T, Pedeutour F: Pleomorphic liposarcoma. Pathology and Genetics of Tumours of Soft Tissue and Bone. Edited by: Fletcher CDM, Unni KK, Mertens F. 2002, Lyon: IARC Press, 641-693.
14.
Schneider-Stock R, Walter H, Radig K, Rys J, Bosse A, Kuhnen C, Hoang-Vu C, Roessner A: MDM2 amplification and loss of heterozygosity at Rb and p53 genes: no simultaneous alterations in the oncogenesis of liposarcomas. J Cancer Res Clin Oncol. 1998, 124: 532-540. 10.1007/s004320050211.CrossRefPubMed
Metadata
Title
Pleomorphic liposarcoma of the foot: a case report
Authors
Luka Brčić
Antonija Jakovčević
Lovorka Batelja Vuletić
Dubravko Orlić
Sven Seiwerth
Publication date
01-12-2008
Publisher
BioMed Central
Published in
Diagnostic Pathology / Issue 1/2008
Electronic ISSN: 1746-1596
DOI
https://doi.org/10.1186/1746-1596-3-15

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