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Current Osteoporosis Reports
Published in: Current Osteoporosis Reports 4/2011

01-12-2011 | Epidemiology and Pathophysiology (Mone Zaidi and Jeffrey I. Mechanick, Section Editors)

Platelet-Rich Plasma for the Replenishment of Bone

Authors: Jameel Iqbal, Samuel H. Pepkowitz, Ellen Klapper

Published in: Current Osteoporosis Reports | Issue 4/2011

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Abstract

This review examines the use of platelet-rich plasma (PRP) in the treatment of bone injuries and to stimulate bone formation. Studies examining both in vivo bone healing and in vitro actions of PRP on osteoblasts are reviewed. Overall, the available literature suggests that PRP does not appreciably impact bone healing or induce bone formation. However, there is some evidence to suggest that PRP might augment recruitment of osteoblast progenitors to injection sites or in sites expected to experience delayed healing. In this capacity PRP might be utilized to initiate repair of an otherwise poorly healing skeletal lesion. The demonstration that PRP is a viable therapy is hindered by a lack of standardized criteria for what constitutes PRP, and more studies are needed to compare the efficacy of PRP to that of transforming growth factor-β or platelet-derived growth factor used as sole agents.
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Metadata
Title
Platelet-Rich Plasma for the Replenishment of Bone
Authors
Jameel Iqbal
Samuel H. Pepkowitz
Ellen Klapper
Publication date
01-12-2011
Publisher
Current Science Inc.
Published in
Current Osteoporosis Reports / Issue 4/2011
Print ISSN: 1544-1873
Electronic ISSN: 1544-2241
DOI
https://doi.org/10.1007/s11914-011-0080-1

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