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01-07-2010

Platelet hyperactivity during exercise leading to iterative coronary stent thrombosis: clinical implications

Authors: Olivier Ormezzano, Benoit Polack, Gérald Vanzetto, Mohamed Sahnoun, Jacques Machecourt

Published in: Journal of Thrombosis and Thrombolysis | Issue 1/2010

Abstract

Exercise may induce platelet activation in spite of using antiplatelet treatment. We present a case where the initial acute coronary syndrome and the iterative stent thrombosis always occurred after intense and prolonged physical effort. For this patient the at rest response to platelet inhibition with antiplatelet treatments was assessed as adequate, but after exercise the patient developed platelet activation which could be the trigger of his stent thrombosis.

Koenig W, Ernst E (2000) Exercise and thrombosis. Coron Artery Dis 11(2):123–127CrossRefPubMed

Wallén NH, Held C, Rehnqvist N, Hjemdahl P (1997) Effects of mental and physical stress on platelet function in patients with stable angina pectoris and healthy controls. Eur Heart J 18(5):807–815PubMed

Tofler GH, Brezinski D, Schafer AI, Czeisler CA, Rutherford JD, Willich SN, Gleason RE, Williams GH, Muller JE (1987) Concurrent morning increase in platelet aggregability and the risk of myocardial infarction and sudden cardiac death. N Engl J Med 316(24):1514–1518PubMedCrossRef

Li N, Wallén NH, Hjemdahl P (1999) Evidence for prothrombotic effects of exercise and limited protection by aspirin. Circulation 100:1374–1379PubMed

Aurigemma C, Fattorossi A, Sestito A, Sgueglia GA, Farnetti S, Buzzonetti A, Infusino F, Landolfi R, Scambia G, Crea F, Lanza GA (2007) Relationship between changes in platelet reactivity and changes in platelet receptor expression induced by physical exercise. Thromb Res 120(6):901–909CrossRefPubMed

Wallén NH, Held C, Rehnqvist N, Hjemdahl P (1995) Platelet aggregability in vivo is attenuated by verapamil but not by metoprolol in patients with stable angina pectoris. Am J Cardiol 75(1):1–6CrossRefPubMed

Hjemdahl P, Larsson PT, Wallén NH (1991) Effects of stress and beta-blockade on platelet function. Circulation 84(6):VI44–VI61PubMed

Pamukcu B, Oflaz H, Acar RD, Umman S, Koylan N, Umman B, Nisanci Y (2005) The role of exercise on platelet aggregation in patients with stable coronary artery disease: exercise induces aspirin resistant platelet activation. J Thromb Thrombolysis 20(1):17–22CrossRefPubMed

Perneby C, Wallén NH, Hu H, Li N, Hjemdahl P (2004) Prothrombotic responses to exercise are little influenced by clopidogrel treatment. Thromb Res 114(4):235–243CrossRefPubMed

10.

Gulmez O, Yildirir A, Bal U, Konas ND, Aydinalp A, Demir O, Atar I, Ertan C, Ozin B, Muderrisoglu H (2007) Assessment of biochemical aspirin resistance at rest and immediately after exercise testing. Blood Coagul Fibrinolysis 18(1):9–13CrossRefPubMed

11.

Perneby C, Wallén NH, Hofman-Bang C, Tornvall P, Ivert T, Li N, Hjemdahl P (2007) Effect of clopidogrel treatment on stress-induced platelet activation and myocardial ischemia in aspirin-treated patients with stable coronary artery disease. Thromb Haemost 98(6):1316–1322PubMed

12.

Thompson PD, Klocke FJ, Levine BD, Van Camp SP (1994) 26th Bethesda conference: recommendations for determining eligibility for competition in athletes with cardiovascular abnormalities Task Force 5: coronary artery disease. Med Sci Sports Exerc 26(10):S271–S275PubMed

Title: Platelet hyperactivity during exercise leading to iterative coronary stent thrombosis: clinical implications
Authors: Olivier Ormezzano
Benoit Polack
Gérald Vanzetto
Mohamed Sahnoun
Jacques Machecourt
Publication date: 01-07-2010
Publisher: Springer US
Published in: Journal of Thrombosis and Thrombolysis / Issue 1/2010
Print ISSN: 0929-5305
Electronic ISSN: 1573-742X
DOI: https://doi.org/10.1007/s11239-009-0394-3

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