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Inflammation
Published in: Inflammation 5/2007

01-10-2007

Platelet Activation During Allergic Inflammation

Authors: Alicja Kasperska-Zajac, Barbara Rogala

Published in: Inflammation | Issue 5/2007

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Abstract

Blood platelets, apart from their traditional and well-recognised function in haemostasis, play an essential and active role in allergic inflammation e.g. through their participation in cell recruitment from blood to site of immune reactivity as a result of direct interactions with leukocytes, and through the release of inflammatory mediators. Platelet activation may occur during human allergic reactions both systemically and locally at the site of allergic inflammation as a result of an IgE-dependent process and as a secondary event caused by other inflammatory or immune stimuli. Altered platelet function as measured by platelet secretion, expression of surface molecules, aggregation, adhesion or arachidonic acid metabolism has been found in patients suffering from allergic diseases. These blood elements have been implicated in the pathogenesis of allergic diseases associated with the so-called atopic diathesis. This paper reviews the platelet activity and reactivity in allergic inflammation, along with our own findings concerning platelet release reaction and the phenomenon of platelet aggregation in patients with different clinical forms of allergy.
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Metadata
Title
Platelet Activation During Allergic Inflammation
Authors
Alicja Kasperska-Zajac
Barbara Rogala
Publication date
01-10-2007
Publisher
Springer US
Published in
Inflammation / Issue 5/2007
Print ISSN: 0360-3997
Electronic ISSN: 1573-2576
DOI
https://doi.org/10.1007/s10753-007-9033-3

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