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Clinical Oral Investigations
Published in: Clinical Oral Investigations 6/2010

Open Access 01-12-2010 | Original Article

Platelet-activating factor levels of serum and gingival crevicular fluid in nonsmoking patients with periodontitis and/or coronary heart disease

Authors: Hui Chen, Pei Zheng, Haihua Zhu, Jianhua Zhu, Lili Zhao, Nour Eddine El Mokhtari, Jörg Eberhard, Markus Lins, Søren Jepsen

Published in: Clinical Oral Investigations | Issue 6/2010

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Abstract

The purpose of the present study was to investigate systemic and local levels of platelet-activating factor (PAF), a potent proinflammatory mediator implicated in cardiovascular pathophysiology in adult nonsmoking patients with periodontitis with or without coronary heart disease (CHD). Eighty-seven volunteers, 25 periodontitis patients, 19 periodontitis with CHD patients, 19 CHD patients, and 24 healthy controls were included, and periodontal conditions were assessed. Gingival crevicular fluid (GCF) and venous blood were collected, and PAF levels were measured by enzyme-linked immunosorbent assay. PAF levels in serum (303.3 ± 204 pg/ml) and in GCF (26.3 ± 6 pg/μl) of the periodontitis group with CHD, the periodontitis group (serum, 302.4 ± 241 pg/ml and GCF, 26.3 ± 8 pg/μl) and the CHD group (serum, 284.7 ± 192 pg/ml and GCF, 20.8 ± 6 pg/μl) were significantly higher than the healthy control group (serum, 65.4 ± 35 pg/ml and GCF, 7.7 ± 3 pg/μl; p < 0.05). In summary, the present study could demonstrate that in patients with periodontitis, the inflammatory mediator PAF is released into serum at least in the same range as for patients with coronary heart disease. However, no additive effects were seen when both conditions were present.
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Metadata
Title
Platelet-activating factor levels of serum and gingival crevicular fluid in nonsmoking patients with periodontitis and/or coronary heart disease
Authors
Hui Chen
Pei Zheng
Haihua Zhu
Jianhua Zhu
Lili Zhao
Nour Eddine El Mokhtari
Jörg Eberhard
Markus Lins
Søren Jepsen
Publication date
01-12-2010
Publisher
Springer-Verlag
Published in
Clinical Oral Investigations / Issue 6/2010
Print ISSN: 1432-6981
Electronic ISSN: 1436-3771
DOI
https://doi.org/10.1007/s00784-009-0346-5

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