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01-02-2012 | Original Article

Plasmin Generation and Fibrinolysis in Pediatric Patients Undergoing Cardiopulmonary Bypass Surgery

Authors: Vera Ignjatovic, Aparajith Chandramouli, Jenny Than, Robyn Summerhayes, Fiona Newall, Steve Horton, Andrew Cochrane, Paul Monagle

Published in: Pediatric Cardiology | Issue 2/2012

Abstract

This prospective, single-centre cohort study aimed to evaluate plasmin generation and fibrinolysis during and after cardiopulmonary bypass (CPB) surgery in a cohort of children up to 6 years of age. Blood samples were drawn at eight time points: after induction of anesthesia, before unfractionated heparin (UFH), after UFH, after initiation of bypass, before protamine, after protamine, after chest closure, and 6 h after chest closure. The study identified an increase in fibrinolysis during CPB and particularly up to 6 h afterward in children. This could be the mechanism for the significant bleeding events observed in this young population after CPB. This study establishes the foundation for future studies in this area, particularly those focusing on clinical outcomes after CPB surgery.

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Title: Plasmin Generation and Fibrinolysis in Pediatric Patients Undergoing Cardiopulmonary Bypass Surgery
Authors: Vera Ignjatovic
Aparajith Chandramouli
Jenny Than
Robyn Summerhayes
Fiona Newall
Steve Horton
Andrew Cochrane
Paul Monagle
Publication date: 01-02-2012
Publisher: Springer-Verlag
Published in: Pediatric Cardiology / Issue 2/2012
Print ISSN: 0172-0643
Electronic ISSN: 1432-1971
DOI: https://doi.org/10.1007/s00246-011-0122-6

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Plasmin Generation and Fibrinolysis in Pediatric Patients Undergoing Cardiopulmonary Bypass Surgery

Abstract

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Abstract

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