Skip to main content
Top
Published in: Urolithiasis 2/2009

01-04-2009 | Original Paper

Plasma oxalate level in pediatric calcium stone formers with or without secondary hyperoxaluria

Authors: Przemysław Sikora, Bodo Beck, Małgorzata Zajączkowska, Bernd Hoppe

Published in: Urolithiasis | Issue 2/2009

Login to get access

Abstract

Plasma oxalate (POx) concentration is significantly elevated in primary hyperoxaluria, severe renal failure or ethylene glycol poisoning. In these conditions, the degree of hyperoxalemia correlates with the severity of systemic calcium oxalate (CaOx) deposition and should be therefore carefully monitored. Although secondary hyperoxaluria (secHyOx) is a common finding in pediatric patients with kidney stone disease, very little is known about POx in this condition. We therefore evaluated POx level in 59 children and adolescence with calcium urolithiasis (34 confirmed by CaOx stone analysis and 25 children with a strong clinical suspicion of this type of urolithiasis), with or without “mild” secHyOx. A control group consisted of 41 healthy sex- and age-matched children. We found that POx was significantly increased in children with calcium urolithiasis and secHyOx compared to healthy children (9.16 ± 3.60 vs. 6.42 ± 2.53 μmol/l), but that was not the case in children with calcium urolithiasis but with normal urinary oxalate excretion (7.12 ± 3.33 μmol/l). We conclude that POx may be slightly increased in some pediatric calcium stone formers with secHyOx, probably related to intestinal oxalate hyperabsorption.
Literature
1.
go back to reference Chalmers RA, Purkiss P (1991) Oxalic acid in plasma and urine. In: Hommes FA (ed) Techniques in diagnostic human biochemical genetics: a laboratory manual. Wiley, New York, pp 359–376 Chalmers RA, Purkiss P (1991) Oxalic acid in plasma and urine. In: Hommes FA (ed) Techniques in diagnostic human biochemical genetics: a laboratory manual. Wiley, New York, pp 359–376
2.
go back to reference Leumann E, Hoppe B (2001) The primary hyperoxalurias. J Am Soc Nephrol 12:1986–1993PubMed Leumann E, Hoppe B (2001) The primary hyperoxalurias. J Am Soc Nephrol 12:1986–1993PubMed
4.
go back to reference Petrarulo M, Bianco O, Marangella M, Pellegrino S, Linari F, Mentasti E (1990) Ion chromatographic determination of plasma oxalate in healthy subjects, in patients with chronic renal failure and in cases of hyperoxaluric syndromes. J Chromatogr A 511:223–231. doi:10.1016/S0021-9673(01)93286-8 CrossRef Petrarulo M, Bianco O, Marangella M, Pellegrino S, Linari F, Mentasti E (1990) Ion chromatographic determination of plasma oxalate in healthy subjects, in patients with chronic renal failure and in cases of hyperoxaluric syndromes. J Chromatogr A 511:223–231. doi:10.​1016/​S0021-9673(01)93286-8 CrossRef
5.
8.
go back to reference Butz M, Kohlbecker G (1980) Oxalate urolithiasis: significance of serum and urinary oxalate. Urol Int 35:303–308PubMedCrossRef Butz M, Kohlbecker G (1980) Oxalate urolithiasis: significance of serum and urinary oxalate. Urol Int 35:303–308PubMedCrossRef
9.
go back to reference Hoshina A (1984) Plasma oxalate concentration in calcium oxalate stone formers. Hinyokika Kiyo 30:1405–1415PubMed Hoshina A (1984) Plasma oxalate concentration in calcium oxalate stone formers. Hinyokika Kiyo 30:1405–1415PubMed
10.
go back to reference Schwille PO, Manoharan R, Rümenapf G, Wölfel G, Berens H (1989) Oxalate measurement in the picomol range by ion chromatography: values in fasting plasma and urine of controls and patients with idiopathic urolithiasis. J Clin Chem Clin Biochem 27:87–96PubMed Schwille PO, Manoharan R, Rümenapf G, Wölfel G, Berens H (1989) Oxalate measurement in the picomol range by ion chromatography: values in fasting plasma and urine of controls and patients with idiopathic urolithiasis. J Clin Chem Clin Biochem 27:87–96PubMed
11.
go back to reference Ogura H (2000) Determinations of oxalate in urine and plasma by capillary electrophoresis. Nippon Hinyokika Gakkai Zasshi 91:547–555PubMed Ogura H (2000) Determinations of oxalate in urine and plasma by capillary electrophoresis. Nippon Hinyokika Gakkai Zasshi 91:547–555PubMed
12.
go back to reference Jadeszko I, Porowski T, Zoch-Zwierz WM, Wasilewska AM, Hackiewicz L (2005) Assessment of oxalate concentration in serum and urine of children with renal stones. Wiad Lek 58(Suppl 1):20–24PubMed Jadeszko I, Porowski T, Zoch-Zwierz WM, Wasilewska AM, Hackiewicz L (2005) Assessment of oxalate concentration in serum and urine of children with renal stones. Wiad Lek 58(Suppl 1):20–24PubMed
14.
go back to reference Schwartz GJ, Haycock GB, Edelmann CM Jr, Spitzer A (1976) A simple estimate of glomerular filtration rate in children derived from body length and plasma creatinine. Pediatrics 58:259–263PubMed Schwartz GJ, Haycock GB, Edelmann CM Jr, Spitzer A (1976) A simple estimate of glomerular filtration rate in children derived from body length and plasma creatinine. Pediatrics 58:259–263PubMed
15.
go back to reference Milliner DS, Murphy ME (1993) Urolithiasis in pediatric patients. Mayo Clin Proc 68:241–248PubMed Milliner DS, Murphy ME (1993) Urolithiasis in pediatric patients. Mayo Clin Proc 68:241–248PubMed
17.
go back to reference Robertson WG, Peacock M (1980) The cause of idiopathic calcium stone disease: hypercalciuria or hyperoxaluria. Nephron 26:105–110PubMedCrossRef Robertson WG, Peacock M (1980) The cause of idiopathic calcium stone disease: hypercalciuria or hyperoxaluria. Nephron 26:105–110PubMedCrossRef
18.
go back to reference Smith LH (1991) Diet and hyperoxaluria in the syndrome of idiopathic calcium oxalate urolithiasis. Am J Kidney Dis 17:370–375PubMed Smith LH (1991) Diet and hyperoxaluria in the syndrome of idiopathic calcium oxalate urolithiasis. Am J Kidney Dis 17:370–375PubMed
19.
go back to reference Porowski T, Zoch-Zwierz W, Konstantynowicz J, Korzeniecka-Kozerska A, Michaluk-Skutnik J, Porowska H (2008) Reference values of plasma oxalate in children and adolescents. Pediatr Nephrol (in press) Porowski T, Zoch-Zwierz W, Konstantynowicz J, Korzeniecka-Kozerska A, Michaluk-Skutnik J, Porowska H (2008) Reference values of plasma oxalate in children and adolescents. Pediatr Nephrol (in press)
20.
go back to reference Petrarulo M, Cerelli E, Marangella M, Maglienti F, Linari F (1993) Ion-chromatographic determination of plasma oxalate reexamined. Clin Chem 39:537–539PubMed Petrarulo M, Cerelli E, Marangella M, Maglienti F, Linari F (1993) Ion-chromatographic determination of plasma oxalate reexamined. Clin Chem 39:537–539PubMed
22.
go back to reference Sikora P, von Unruh GE, Beck B, Feldkötter M, Zajączkowska M, Hoppe B (2008) [13C2]oxalate absorption in children with idiopathic calcium oxalate urolithiasis or primary hyperoxaluria. Kidney Int 73:1181–1186. doi:10.1038/ki.2008.63 PubMedCrossRef Sikora P, von Unruh GE, Beck B, Feldkötter M, Zajączkowska M, Hoppe B (2008) [13C2]oxalate absorption in children with idiopathic calcium oxalate urolithiasis or primary hyperoxaluria. Kidney Int 73:1181–1186. doi:10.​1038/​ki.​2008.​63 PubMedCrossRef
24.
go back to reference Wharton R, D’Agati V, Magun AM, Whitlock R, Kunis CL, Appel GB (1990) Acute deterioration of renal function associated with enteric hyperoxaluria. Clin Nephrol 34:116–121PubMed Wharton R, D’Agati V, Magun AM, Whitlock R, Kunis CL, Appel GB (1990) Acute deterioration of renal function associated with enteric hyperoxaluria. Clin Nephrol 34:116–121PubMed
25.
go back to reference Kiss D, Meier R, Gyr K, Wegmann W (1992) Sekundäre Oxalose nach Dündarmresektion mit Niereninsuffizienz und Oxalatvaskulopathie. Schweiz Med Wschr 122:854–857PubMed Kiss D, Meier R, Gyr K, Wegmann W (1992) Sekundäre Oxalose nach Dündarmresektion mit Niereninsuffizienz und Oxalatvaskulopathie. Schweiz Med Wschr 122:854–857PubMed
26.
go back to reference Hassan I, Juncos LA, Milliner DS, Sarmiento JM, Sarr MG (2001) Chronic renal failure secondary to oxalate nephropathy: a preventable complication after jejunoileal bypass. Mayo Clin Proc 76:758–760PubMedCrossRef Hassan I, Juncos LA, Milliner DS, Sarmiento JM, Sarr MG (2001) Chronic renal failure secondary to oxalate nephropathy: a preventable complication after jejunoileal bypass. Mayo Clin Proc 76:758–760PubMedCrossRef
Metadata
Title
Plasma oxalate level in pediatric calcium stone formers with or without secondary hyperoxaluria
Authors
Przemysław Sikora
Bodo Beck
Małgorzata Zajączkowska
Bernd Hoppe
Publication date
01-04-2009
Publisher
Springer-Verlag
Published in
Urolithiasis / Issue 2/2009
Print ISSN: 2194-7228
Electronic ISSN: 2194-7236
DOI
https://doi.org/10.1007/s00240-009-0179-3

Other articles of this Issue 2/2009

Urolithiasis 2/2009 Go to the issue