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Indian Journal of Pediatrics
Published in: Indian Journal of Pediatrics 5/2016

01-05-2016 | Scientific Letter

Plasma Folate, Vitamin B12 and Homocysteine Levels in Children with Solid Tumors at Diagnosis; Results from a Pediatric Referral Centre

Authors: Despoina N. Maritsi, George Vartzelis, Helen Dana, Helen Kosmidis, Varvara Douna, Lydia Kossiva

Published in: Indian Journal of Pediatrics | Issue 5/2016

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Excerpt

To the Editor: Low folate, low vitamin B12 and elevated homocysteine levels are considered as possible factors predisposing for malignancies in children and adults. Little is known about the concentration of these micronutrients in children with cancer. …
Literature
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Zhang D, Wen X, Wu W, Guo Y, Cui W. Elevated homocysteine level and folate deficiency associated with increased overall risk of carcinogenesis: meta-analysis of 83 case–control studies involving 35,758 individuals. PLoS One. 2015;10:e0123423.CrossRefPubMedPubMedCentral
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Linabery AM, Johnson KJ, Ross JA. Childhood cancer incidence trends in association with US folic acid fortification (1986–2008). Pediatrics. 2012;129:1125–33.CrossRefPubMedPubMedCentral
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Grupp SG, Greenberg ML, Ray JG, et al. Pediatric cancer rates after universal folic acid flour fortification in Ontario. J Clin Pharmacol. 2011;51:60–5.CrossRefPubMed
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Milne E, Greenop KR, Bower C, et al. Maternal use of folic acid and other supplements and risk of childhood brain tumors. Cancer Epidemiol Biomark Prev. 2012;21:1933–41.CrossRef
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Aleksic D, Djokic D, Golubicic I, Jakovljevic V, Djuric D. The importance of the blood levels of homocysteine, folic acid and vitamin B12 in children with malignant diseases. J BUON. 2013;18:1019–25.PubMed
Metadata
Title
Plasma Folate, Vitamin B12 and Homocysteine Levels in Children with Solid Tumors at Diagnosis; Results from a Pediatric Referral Centre
Authors
Despoina N. Maritsi
George Vartzelis
Helen Dana
Helen Kosmidis
Varvara Douna
Lydia Kossiva
Publication date
01-05-2016
Publisher
Springer India
Published in
Indian Journal of Pediatrics / Issue 5/2016
Print ISSN: 0019-5456
Electronic ISSN: 0973-7693
DOI
https://doi.org/10.1007/s12098-015-1892-2

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