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Open Access 01-02-2019 | Review

Plant and human aquaporins: pathogenesis from gut to brain

Authors: Jama Lambert, Soledad Mejia, Aristo Vojdani

Published in: Immunologic Research | Issue 1/2019

Abstract

Corn, soybean, spinach leaf, and tomato aquaporins have been shown to share homology with human aquaporin-4, which is abundantly expressed by brain astrocytic endfeet. Thus, antibodies formed against the dietary aquaporins may potentially cross-react with brain aquaporin, leading to blood-brain barrier permeability and setting the stage for neuroautoimmunity and neurodegeneration. Here, we review the role of aquaporins in plants and humans in maintaining a healthy organism and mechanisms by which dietary aquaporins may contribute to neurological disorders. We include clinical data on the correlation between four real-world, dietary aquaporin and five neurological tissue antibodies. Our findings showed the percent of neurological tissue antibody production increased with the number of positive food aquaporins. Of the four food aquaporins, spinach was the most common reactive. Of the neurological tissues assessed, tubulin was the most common positive. Patients with antibody reactivity to dietary aquaporins may consider abstaining from the aquaporin-containing food in order to prevent neurological tissue damage.

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Title: Plant and human aquaporins: pathogenesis from gut to brain
Authors: Jama Lambert
Soledad Mejia
Aristo Vojdani
Publication date: 01-02-2019
Publisher: Springer US
Published in: Immunologic Research / Issue 1/2019
Print ISSN: 0257-277X
Electronic ISSN: 1559-0755
DOI: https://doi.org/10.1007/s12026-018-9046-z

At a glance: The STEP trials

Springer Medicine

Plant and human aquaporins: pathogenesis from gut to brain

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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