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Annals of Nuclear Medicine
Published in: Annals of Nuclear Medicine 4/2017

Open Access 01-05-2017 | Original Article

Pixel-by-pixel precise delay correction for measurement of cerebral hemodynamic parameters in H2 15O PET study

Authors: Muhammad M. Islam, Tetsuya Tsujikawa, Tetsuya Mori, Yasushi Kiyono, Hidehiko Okazawa

Published in: Annals of Nuclear Medicine | Issue 4/2017

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Abstract

Objective

A new method of delay time estimation was proposed to measure precise cerebral blood flow (CBF) and arterial-to-capillary blood volume (V 0) using 15O-water PET.

Methods

Nineteen patients with unilateral arterial stenoocclusive lesions were studied to evaluate hemodynamic status before treatment. The delay time of each pixel was calculated using least squares fitting with an arterial blood input curve adjusted to the internal carotid artery counts at the skull base. Pixel-by-pixel delay estimation provided a delay map image that could be used for precise calculation of CBF and V 0 using a one-tissue compartment model, and the values from this method were compared with those from the slice-by-slice correction method.

Results

The affected side showed a longer delay time than the contralateral cerebral hemisphere. Although the mean cortical CBF values were not different between the two methods, the slice-by-slice delay correction overestimated CBF in the hypo perfused area. The scatter plot of V 0 pixel values showed significant difference between the two correction methods where the slice-by-slice delay correction significantly overestimated V 0 in the whole brain (P < 0.05).

Conclusion

Pixel-by-pixel delay correction provides delay images as well as better estimation of CBF and V 0, thus offering useful and beneficial information for the treatment of cerebrovascular disease.
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Metadata
Title
Pixel-by-pixel precise delay correction for measurement of cerebral hemodynamic parameters in H2 15O PET study
Authors
Muhammad M. Islam
Tetsuya Tsujikawa
Tetsuya Mori
Yasushi Kiyono
Hidehiko Okazawa
Publication date
01-05-2017
Publisher
Springer Japan
Published in
Annals of Nuclear Medicine / Issue 4/2017
Print ISSN: 0914-7187
Electronic ISSN: 1864-6433
DOI
https://doi.org/10.1007/s12149-017-1156-5

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