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28-04-2023 | Pituitary Adenoma

Measuring pituitary tumor volume: a comparison of the simplified and non-simplified ellipsoid equation with the 3D planimetric volume assessment

Authors: Romullo Lameck Pereira de Figueiredo, Joilson Francisco de Souza Junior, Patrick Joaner Lobo Triarca, Andre Beer-Furlan, Nelson Almeida Davila Melo, Bruno Fernandes de Oliveira Santos, Arthur Maynart Pereira Oliveira

Published in: Pituitary | Issue 4/2023

Abstract

Purpose

The ellipsoid equation came in an attempt to facilitate the estimation of tumor volume, by measuring the height, width, and anteroposterior length of the lesion. The estimated tumor volume can sometimes be different between methods, thus, it is of extreme interest to evaluate if the methods are significantly different, as well as to discuss the main limitations of each one.

Methods

This is an observational, analytical, cross-sectional study. A systematic review of the literature was also performed in order to discuss the results observed in the present study.

Results

A total of 82 patients (43 males and 39 females) ranging in age from 15 to 78 years (mean 47.95 ± 14.76) were included in the study. Seven patients were classified as Knosp grade 0 (8.5%), 36 Knosp grade 1 (44%), 14 Knosp grade 2 (17%), 20 Knosp grade 3 (24.4%), 5 Knosp grade 4 (6.1%). The tumor volume estimated by 3D planimetric assessment, non-simplified ellipsoid equation, and simplified ellipsoid formula averaged 10.68 cm³, 10.36 cm³, and 9.9 cm³ respectively.

Conclusion

A simplified form of the ellipsoid equation increases the divergence between the measurement obtained in planimetry, and should be discouraged, in view of the new automated methods of performing quick calculations using periodic digits. The non-simplified form underestimated the tumor volume by 2.9% on average but did so regularly. In clinical practice, measurement should be accompanied by an evaluation of tumor morphology.

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Title: Measuring pituitary tumor volume: a comparison of the simplified and non-simplified ellipsoid equation with the 3D planimetric volume assessment
Authors: Romullo Lameck Pereira de Figueiredo
Joilson Francisco de Souza Junior
Patrick Joaner Lobo Triarca
Andre Beer-Furlan
Nelson Almeida Davila Melo
Bruno Fernandes de Oliveira Santos
Arthur Maynart Pereira Oliveira
Publication date: 28-04-2023
Publisher: Springer US
Keyword: Pituitary Adenoma
Published in: Pituitary / Issue 4/2023
Print ISSN: 1386-341X
Electronic ISSN: 1573-7403
DOI: https://doi.org/10.1007/s11102-023-01317-4

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Abstract

Purpose

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