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Published in: Journal of Nuclear Cardiology 3/2017

01-06-2017 | Images that Teach

Pitfalls of 18F-FDG PET for evaluating myocardial viability

Authors: Osamu Manabe, MD, PhD, Noriko Oyama-Manabe, MD, PhD, Masanao Naya, MD, PhD, Tadao Aikawa, MD, Mamoru Sakakibara, MD, PhD, Hiroyuki Tsutsui, MD, PhD, Nagara Tamaki, MD, PhD

Published in: Journal of Nuclear Cardiology | Issue 3/2017

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Excerpt

The assessment of myocardial viability is essential for the care and treatment of myocardial infarction patients. 18F-fluorodeoxyglucose (18F-FDG) is an analog of glucose that is taken up in viable myocardial cells by the glucose transporters.1 18F-FDG positron emission tomography (PET) is a powerful functional imaging tool for quantifying the viability of the myocardial tissue. 18F-FDG PET is also well known as an investigation of active inflammation. We showed a representative case with 18F-FDG uptake in the area with severe hypo-perfusion, which was a false-positive result of the recent myocardial infarction due to the inflammation. …
Literature
1.
go back to reference Bulluck H, White SK, Fröhlich GM, Casson SG, O’Meara C, Newton A, et al. Quantifying the area at risk in reperfused ST-segment-elevation myocardial infarction patients using hybrid cardiac positron emission tomography-magnetic resonance imaging. Circ Cardiovasc Imaging 2016;9:e003900.CrossRefPubMedPubMedCentral Bulluck H, White SK, Fröhlich GM, Casson SG, O’Meara C, Newton A, et al. Quantifying the area at risk in reperfused ST-segment-elevation myocardial infarction patients using hybrid cardiac positron emission tomography-magnetic resonance imaging. Circ Cardiovasc Imaging 2016;9:e003900.CrossRefPubMedPubMedCentral
2.
go back to reference Wu YW, Tadamura E, Kanao S, Yamamuro M, Marui A, Komeda M, et al. Myocardial viability by contrast-enhanced cardiovascular magnetic resonance in patients with coronary artery disease: comparison with gated single-photon emission tomography and FDG position emission tomography. Int J Cardiovasc Imaging 2007;23:757–65.CrossRefPubMed Wu YW, Tadamura E, Kanao S, Yamamuro M, Marui A, Komeda M, et al. Myocardial viability by contrast-enhanced cardiovascular magnetic resonance in patients with coronary artery disease: comparison with gated single-photon emission tomography and FDG position emission tomography. Int J Cardiovasc Imaging 2007;23:757–65.CrossRefPubMed
3.
go back to reference Manabe O, Ohira H, Yoshinaga K, Sato T, Klaipetch A, Oyama-Manabe N, et al. Elevated (18)F-fluorodeoxyglucose uptake in the interventricular septum is associated with atrioventricular block in patients with suspected cardiac involvement sarcoidosis. Eur J Nucl Med Mol Imaging 2013;40:1558–66.CrossRefPubMed Manabe O, Ohira H, Yoshinaga K, Sato T, Klaipetch A, Oyama-Manabe N, et al. Elevated (18)F-fluorodeoxyglucose uptake in the interventricular septum is associated with atrioventricular block in patients with suspected cardiac involvement sarcoidosis. Eur J Nucl Med Mol Imaging 2013;40:1558–66.CrossRefPubMed
4.
go back to reference Lee WW, Marinelli B, van der Laan AM, Sena BF, Gorbatov R, Leuschner F, et al. PET/MRI of inflammation in myocardial infarction. J Am Coll Cardiol 2012;59:153–63.CrossRefPubMedPubMedCentral Lee WW, Marinelli B, van der Laan AM, Sena BF, Gorbatov R, Leuschner F, et al. PET/MRI of inflammation in myocardial infarction. J Am Coll Cardiol 2012;59:153–63.CrossRefPubMedPubMedCentral
5.
go back to reference Nahrendorf M, Pittet MJ, Swirski FK. Monocytes: protagonists of infarct inflammation and repair after myocardial infarction. Circulation 2010;121:2437–45.CrossRefPubMedPubMedCentral Nahrendorf M, Pittet MJ, Swirski FK. Monocytes: protagonists of infarct inflammation and repair after myocardial infarction. Circulation 2010;121:2437–45.CrossRefPubMedPubMedCentral
7.
go back to reference Reimer KA, Jennings RB. Circulation. The changing anatomic reference base of evolving myocardial infarction. Underestimation of myocardial collateral blood flow and overestimation of experimental anatomic infarct size due to tissue edema. Hemorrhage Acute Inflamm 1979;60:866–76. Reimer KA, Jennings RB. Circulation. The changing anatomic reference base of evolving myocardial infarction. Underestimation of myocardial collateral blood flow and overestimation of experimental anatomic infarct size due to tissue edema. Hemorrhage Acute Inflamm 1979;60:866–76.
8.
go back to reference Korkusuz H, Esters P, Huebner F, Bug R, Ackermann H, Vogl TJ. Accuracy of cardiovascular magnetic resonance in myocarditis: comparison of MR and histological findings in an animal model. J Cardiovasc Magn Reson 2010;26:49.CrossRef Korkusuz H, Esters P, Huebner F, Bug R, Ackermann H, Vogl TJ. Accuracy of cardiovascular magnetic resonance in myocarditis: comparison of MR and histological findings in an animal model. J Cardiovasc Magn Reson 2010;26:49.CrossRef
9.
go back to reference Abdel-Aty H, Zagrosek A, Schulz-Menger J, Taylor AJ, Messroghli D, Kumar A, et al. Delayed enhancement and T2-weighted cardiovascular magnetic resonance imaging differentiate acute from chronic myocardial infarction. Circulation 2004;109:2411–6.CrossRefPubMed Abdel-Aty H, Zagrosek A, Schulz-Menger J, Taylor AJ, Messroghli D, Kumar A, et al. Delayed enhancement and T2-weighted cardiovascular magnetic resonance imaging differentiate acute from chronic myocardial infarction. Circulation 2004;109:2411–6.CrossRefPubMed
Metadata
Title
Pitfalls of 18F-FDG PET for evaluating myocardial viability
Authors
Osamu Manabe, MD, PhD
Noriko Oyama-Manabe, MD, PhD
Masanao Naya, MD, PhD
Tadao Aikawa, MD
Mamoru Sakakibara, MD, PhD
Hiroyuki Tsutsui, MD, PhD
Nagara Tamaki, MD, PhD
Publication date
01-06-2017
Publisher
Springer US
Published in
Journal of Nuclear Cardiology / Issue 3/2017
Print ISSN: 1071-3581
Electronic ISSN: 1532-6551
DOI
https://doi.org/10.1007/s12350-016-0572-6

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