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Molecular Imaging and Biology
Published in: Molecular Imaging and Biology 3/2019

01-06-2019 | Research Article

Physiological Whole-Brain Distribution of [18F]FDOPA Uptake Index in Relation to Age and Gender: Results from a Voxel-Based Semi-quantitative Analysis

Authors: Sinn-Rithy Toch, Sylvain Poussier, Emilien Micard, Marc Bertaux, Axel Van Der Gucht, Elodie Chevalier, Pierre-Yves Marie, Eric Guedj, Antoine Verger

Published in: Molecular Imaging and Biology | Issue 3/2019

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Abstract

Purpose

6-[18F]fluoro-l-DOPA ([18F]FDOPA), a positron emission tomography (PET) amino-acid tracer of brain decarboxylase activity, is used to assess the brain dopaminergic system. Using a voxel-based semi-quantitative analysis, this study aimed to determine whether a current brain uptake index of [18F]FDOPA, expressed relative to the occipital background level, varies according to age and gender.

Procedures

One hundred and seventy-seven subjects were retrospectively included. A whole-brain statistical parametric mapping analysis of the [18F]FDOPA uptake index in parametric PET images was performed at a voxel threshold of p < 0.05 (corrected) and p < 0.005 (uncorrected, k cluster > 125).

Results

Striatal uptake indices were influenced by age, negatively for the caudate nucleus and positively for the putamen, as well as by gender, with a lower left putaminal uptake index in women. Extra-striatal uptake indices were influenced by age, negatively for the frontal cortex and brainstem and positively for the occipital cortex and cerebellum, as well as by gender (diffuse increase in women).

Conclusions

The uptake index of [18F]FDOPA exhibited significant physiological variations according to age and gender and should therefore be considered for PET interpretation.
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Metadata
Title
Physiological Whole-Brain Distribution of [18F]FDOPA Uptake Index in Relation to Age and Gender: Results from a Voxel-Based Semi-quantitative Analysis
Authors
Sinn-Rithy Toch
Sylvain Poussier
Emilien Micard
Marc Bertaux
Axel Van Der Gucht
Elodie Chevalier
Pierre-Yves Marie
Eric Guedj
Antoine Verger
Publication date
01-06-2019
Publisher
Springer International Publishing
Published in
Molecular Imaging and Biology / Issue 3/2019
Print ISSN: 1536-1632
Electronic ISSN: 1860-2002
DOI
https://doi.org/10.1007/s11307-018-1256-1

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