Physical exercise and dementia in patients with type 2 diabetes mellitus

Excerpt

I read with interest the recent review by Bertram et al. [1], in Endocrine. The authors overviewed the epidemiological association between type 2 diabetes mellitus (T2DM) and dementia, and speculated the biological mechanism on the association with special reference to chronic inflammation, oxidative stress, dyslipidemia, reduced β-amyloid clearance, and hormonal change. Thereafter, the authors intensively summarized the effect of physical exercise on dementia prevention in patients with T2DM. I fundamentally accept their recommendation of physical exercise, although biological evidence seems not enough to confirm the causal association. I have some concerns on their summary. …