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01-09-2013 | Original paper

Physical activity and other lifestyle factors in relation to the prevalence of colorectal adenoma: a colonoscopy-based study in asymptomatic Koreans

Authors: Ji Hyun Song, Young Sun Kim, Sun Young Yang, Su Jin Chung, Min Jung Park, Seon Hee Lim, Jeong Yoon Yim, Joo Sung Kim, Hyun Chae Jung

Published in: Cancer Causes & Control | Issue 9/2013

Abstract

Purpose

To evaluate physical activity and other lifestyle risk factors in relation to the prevalence of colorectal adenomas in asymptomatic Koreans.

Methods

A total of 1,526 asymptomatic subjects who underwent a colonoscopy were enrolled. Lifestyle factors such as physical activity and smoking data were obtained using a questionnaire. The subjects were grouped into three exposure levels by tertiles of metabolic equivalent hours per week. We evaluated the risk factors in subjects with adenomas by risk stratification (low-risk adenoma group vs. high-risk adenoma group) and by anatomic location (proximal colon, distal colon, rectum, and multiple locations). The high-risk adenoma group was defined as subjects with advanced adenomas or multiple (≥3) adenomas.

Results

A total of 456 participants had colorectal adenomas, and 861 had no polyps. In multivariate analyses, higher levels of physical activity were associated with a significantly decreased risk of colorectal adenomas (OR = 0.56, 95 % CI 0.40–0.79). This inverse association was stronger for the risk of high-risk adenomas (OR = 0.39, 95 % CI 0.21–0.73) than for low-risk adenomas (OR = 0.62, 95 % CI 0.43–0.89). The negative relation of physical activity was significant for distal colon adenomas (OR = 0.54, 95 % CI 0.30–0.95) and the adenomas with multiple locations (OR = 0.39, 95 % CI 0.21–0.72).

Conclusions

Increased physical activity is associated with a reduced prevalence of colorectal adenomas. The inverse association between physical activity and adenoma was stronger for the risk of advanced or multiple adenomas.

Stewart B, Kleihues P (2003) World cancer report. IARC Press, Lyon

Sung JJ, Lau JY, Goh KL, Leung WK (2005) Increasing incidence of colorectal cancer in Asia: implications for screening. Lancet Oncol 6:871–876PubMedCrossRef

Registry KCC (2002) Annual report of the Korea Central Cancer Registry. Ministry of Health and Welfare and National Cancer Center, Republic of Korea

Kim YS, Kim N, Kim SH et al (2008) The efficacy of intravenous contrast-enhanced 16-raw multidetector CT colonography for detecting patients with colorectal polyps in an asymptomatic population in Korea. J Clin Gastroenterol 42:791–798PubMedCrossRef

Lieberman DA, Weiss DG, Bond JH, Ahnen DJ, Garewal H, Chejfec G (2000) Use of colonoscopy to screen asymptomatic adults for colorectal cancer. Veterans affairs cooperative study group 380. N Engl J Med 343:162–168PubMedCrossRef

Lieberman DA, Smith FW (1991) Screening for colon malignancy with colonoscopy. Am J Gastroenterol 86:946–951PubMed

Wallace K, Baron JA, Karagas MR et al (2005) The association of physical activity and body mass index with the risk of large bowel polyps. Cancer Epidemiol Biomarkers Prev 14:2082–2086PubMedCrossRef

Hill MJ, Morson BC, Bussey HJ (1978) Aetiology of adenoma–carcinoma sequence in large bowel. Lancet 1:245–247PubMedCrossRef

Winawer SJ, Zauber AG, Ho MN et al (1993) Prevention of colorectal cancer by colonoscopic polypectomy. The national polyp study workgroup. N Engl J Med 329:1977–1981PubMedCrossRef

10.

Thiis-Evensen E, Hoff GS, Sauar J, Langmark F, Majak BM, Vatn MH (1999) Population-based surveillance by colonoscopy: effect on the incidence of colorectal cancer. Telemark polyp study I. Scand J Gastroenterol 34:414–420PubMedCrossRef

11.

Gelfand DW (1997) Decreased risk of subsequent colonic cancer in patients undergoing polypectomy after barium enema: analysis based on data from the preendoscopic era. AJR Am J Roentgenol 169:1243–1245PubMedCrossRef

12.

Haydon AM, Macinnis RJ, English DR, Giles GG (2006) Effect of physical activity and body size on survival after diagnosis with colorectal cancer. Gut 55:62–67PubMedCrossRef

13.

Kang HW, Kim D, Kim HJ et al (2010) Visceral obesity and insulin resistance as risk factors for colorectal adenoma: a cross-sectional, case-control study. Am J Gastroenterol 105:178–187PubMedCrossRef

14.

Shin A, Hong CW, Sohn DK et al (2011) Associations of cigarette smoking and alcohol consumption with advanced or multiple colorectal adenoma risks: a colonoscopy-based case-control study in Korea. Am J Epidemiol 174:552–562PubMedCrossRef

15.

Botteri E, Iodice S, Raimondi S, Maisonneuve P, Lowenfels AB (2008) Cigarette smoking and adenomatous polyps: a meta-analysis. Gastroenterology 134:388–395PubMedCrossRef

16.

Lieberman DA, Prindiville S, Weiss DG, Willett W (2003) Risk factors for advanced colonic neoplasia and hyperplastic polyps in asymptomatic individuals. JAMA 290:2959–2967PubMedCrossRef

17.

Giovannucci E, Rimm EB, Stampfer MJ, Colditz GA, Ascherio A, Willett WC (1994) Aspirin use and the risk for colorectal cancer and adenoma in male health professionals. Ann Intern Med 121:241–246PubMedCrossRef

18.

Sandler RS, Galanko JC, Murray SC, Helm JF, Woosley JT (1998) Aspirin and nonsteroidal anti-inflammatory agents and risk for colorectal adenomas. Gastroenterology 114:441–447PubMedCrossRef

19.

Hauret KG, Bostick RM, Matthews CE et al (2004) Physical activity and reduced risk of incident sporadic colorectal adenomas: observational support for mechanisms involving energy balance and inflammation modulation. Am J Epidemiol 159:983–992PubMedCrossRef

20.

Rosenberg L, Boggs D, Wise LA et al (2006) A follow-up study of physical activity and incidence of colorectal polyps in African-American women. Cancer Epidemiol Biomarkers Prev 15:1438–1442PubMedCrossRef

21.

Giovannucci E, Colditz GA, Stampfer MJ, Willett WC (1996) Physical activity, obesity, and risk of colorectal adenoma in women (United States). Cancer Causes Control 7:253–263PubMedCrossRef

22.

Hermann S, Rohrmann S, Linseisen J (2009) Lifestyle factors, obesity and the risk of colorectal adenomas in EPIC-Heidelberg. Cancer Causes Control 20:1397–1408PubMedCrossRef

23.

Larsen IK, Grotmol T, Almendingen K, Hoff G (2006) Lifestyle as a predictor for colonic neoplasia in asymptomatic individuals. BMC Gastroenterol 6:5PubMedCrossRef

24.

Chung SJ, Kim YS, Yang SY et al (2011) Five-year risk for advanced colorectal neoplasia after initial colonoscopy according to the baseline risk stratification: a prospective study in 2452 asymptomatic Koreans. Gut 60:1537–1543PubMedCrossRef

25.

Ainsworth BE, Haskell WL, Whitt MC et al (2000) Compendium of physical activities: an update of activity codes and MET intensities. Med Sci Sports Exerc 32:S498–S504PubMedCrossRef

26.

Giovannucci E (1995) Insulin and colon cancer. Cancer Causes Control 6:164–179PubMedCrossRef

27.

Wei EK, Ma J, Pollak MN et al (2006) C-peptide, insulin-like growth factor binding protein-1, glycosylated hemoglobin, and the risk of distal colorectal adenoma in women. Cancer Epidemiol Biomarkers Prev 15:750–755PubMedCrossRef

28.

Boutron-Ruault MC, Senesse P, Meance S, Belghiti C, Faivre J (2001) Energy intake, body mass index, physical activity, and the colorectal adenoma-carcinoma sequence. Nutr Cancer 39:50–57PubMedCrossRef

29.

Friedenreich CM, Orenstein MR (2002) Physical activity and cancer prevention: etiologic evidence and biological mechanisms. J Nutr 132:S3456–S3464

30.

Wertheim BC, Martinez ME, Ashbeck EL et al (2009) Physical activity as a determinant of fecal bile acid levels. Cancer Epidemiol Biomarkers Prev 18:1591–1598PubMedCrossRef

31.

Wolin KY, Lee IM, Colditz GA, Glynn RJ, Fuchs C, Giovannucci E (2007) Leisure-time physical activity patterns and risk of colon cancer in women. Int J Cancer 121:2776–2781PubMedCrossRef

32.

Slattery ML (2004) Physical activity and colorectal cancer. Sports Med 34:239–252PubMedCrossRef

33.

Kono S, Handa K, Hayabuchi H et al (1999) Obesity, weight gain and risk of colon adenomas in Japanese men. Jpn J Cancer Res 90:805–811PubMedCrossRef

34.

Colbert LH, Lanza E, Ballard-Barbash R et al (2002) Adenomatous polyp recurrence and physical activity in the polyp prevention trial (United States). Cancer Causes Control 13:445–453PubMedCrossRef

35.

Kono S, Shinchi K, Ikeda N, Yanai F, Imanishi K (1991) Physical activity, dietary habits and adenomatous polyps of the sigmoid colon: a study of self-defense officials in Japan. J Clin Epidemiol 44:1255–1261PubMedCrossRef

36.

Anderson JC, Attam R, Alpern Z et al (2003) Prevalence of colorectal neoplasia in smokers. Am J Gastroenterol 98:2777–2783PubMedCrossRef

37.

Nagata C, Shimizu H, Kametani M, Takeyama N, Ohnuma T, Matsushita S (1999) Cigarette smoking, alcohol use, and colorectal adenoma in Japanese men and women. Dis Colon Rectum 42:337–342PubMedCrossRef

38.

Toyomura K, Yamaguchi K, Kawamoto H et al (2004) Relation of cigarette smoking and alcohol use to colorectal adenomas by subsite: the self-defense forces health study. Cancer Sci 95:72–76PubMedCrossRef

39.

Erhardt JG, Kreichgauer HP, Meisner C, Bode JC, Bode C (2002) Alcohol, cigarette smoking, dietary factors and the risk of colorectal adenomas and hyperplastic polyps–a case control study. Eur J Nutr 41:35–43PubMedCrossRef

40.

Giovannucci E, Ascherio A, Rimm EB, Colditz GA, Stampfer MJ, Willett WC (1995) Physical activity, obesity, and risk for colon cancer and adenoma in men. Ann Intern Med 122:327–334PubMedCrossRef

41.

Wang YY, Lin SY, Lai WA, Liu PH, Sheu WH (2005) Association between adenomas of rectosigmoid colon and metabolic syndrome features in a Chinese population. J Gastroenterol Hepatol 20:1410–1415PubMedCrossRef

42.

Kim JH, Lim YJ, Kim YH et al (2007) Is metabolic syndrome a risk factor for colorectal adenoma? Cancer Epidemiol Biomarkers Prev 16:1543–1546PubMedCrossRef

43.

Liu CS, Hsu HS, Li CI et al (2010) Central obesity and atherogenic dyslipidemia in metabolic syndrome are associated with increased risk for colorectal adenoma in a Chinese population. BMC Gastroenterol 10:51PubMedCrossRef

44.

Kaneko R, Sato Y, An Y et al (2010) Clinico-epidemiologic study of the metabolic syndrome and lifestyle factors associated with the risk of colon adenoma and adenocarcinoma. Asian Pac J Cancer Prev 11:975–983PubMed

Title: Physical activity and other lifestyle factors in relation to the prevalence of colorectal adenoma: a colonoscopy-based study in asymptomatic Koreans
Authors: Ji Hyun Song
Young Sun Kim
Sun Young Yang
Su Jin Chung
Min Jung Park
Seon Hee Lim
Jeong Yoon Yim
Joo Sung Kim
Hyun Chae Jung
Publication date: 01-09-2013
Publisher: Springer Netherlands
Published in: Cancer Causes & Control / Issue 9/2013
Print ISSN: 0957-5243
Electronic ISSN: 1573-7225
DOI: https://doi.org/10.1007/s10552-013-0247-4

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Abstract

Purpose

Methods

Results

Conclusions

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