Skip to main content
Top
Published in: Sports Medicine 7/2008

01-07-2008 | Review Article

Physical Activity and Epilepsy

Proven and Predicted Benefits

Authors: Dr Ricardo M. Arida, Esper A. Cavalheiro, Antonio C. da Silva, Fulvio A. Scorza

Published in: Sports Medicine | Issue 7/2008

Login to get access

Abstract

Epilepsy is a common disease found in 2% of the population, affecting people from all ages. Unfortunately, persons with epilepsy have previously been discouraged from participation in physical activity and sports for fear of inducing seizures or increasing seizure frequency. Despite a shift in medical recommendations toward encouraging rather than restricting participation, the stigma remains and persons with epilepsy continue to be less active than the general population. For this purpose, clinical and experimental studies have analysed the effect of physical exercise on epilepsy. Although there are rare cases of exercise-induced seizures, studies have shown that physical activity can decrease seizure frequency, as well as lead to improved cardiovascular and psychological health in people with epilepsy. The majority of physical activities or sports are safe for people with epilepsy to participate in with special attention to adequate seizure control, close monitoring of medications, and preparation of family or trainers. The evidence shows that patients with good seizure control can participate in both contact and non-contact sports without harmfully affecting seizure frequency. This article reviews the risks and benefits of physical activity in people with epilepsy, discusses sports in which persons with epilepsy may participate, and describes the positive effect of physical exercise in experimental models of epilepsy.
Literature
2.
go back to reference Begley CE, Annegers JF, Lairson LB, et al. Epilepsy incidence, prognosis, and use of medical care in Houston, Texas, and Rochester, Minnesota. Epilepsia 1998; 39 Suppl. 6: 222 Begley CE, Annegers JF, Lairson LB, et al. Epilepsy incidence, prognosis, and use of medical care in Houston, Texas, and Rochester, Minnesota. Epilepsia 1998; 39 Suppl. 6: 222
3.
go back to reference Annegers JF. Epidemiology of epilepsy. In: Wyllie E, editor. The treatment of epilepsy: principles and practice. Baltimore (MD): Williams & Wilkins, 1997: 165–72 Annegers JF. Epidemiology of epilepsy. In: Wyllie E, editor. The treatment of epilepsy: principles and practice. Baltimore (MD): Williams & Wilkins, 1997: 165–72
4.
go back to reference Yuen AW, Sander JW. Is omega–3 fatty acid deficiency a factor contributing to refractory seizures and SUDEP? A hypothesis. Seizure 2004; 13: 104–7PubMedCrossRef Yuen AW, Sander JW. Is omega–3 fatty acid deficiency a factor contributing to refractory seizures and SUDEP? A hypothesis. Seizure 2004; 13: 104–7PubMedCrossRef
5.
go back to reference Kwan P, Sander JW. The natural history of epilepsy: an epidemiological view. J Neurol Neurosurg Psychiatry 2004; 75: 1376–81PubMedCrossRef Kwan P, Sander JW. The natural history of epilepsy: an epidemiological view. J Neurol Neurosurg Psychiatry 2004; 75: 1376–81PubMedCrossRef
6.
7.
go back to reference Halatchev VN. Epidemiology of epilepsy: recent achievements and future. Folia Medica (Plovdiv) 2000; 42: 17–22 Halatchev VN. Epidemiology of epilepsy: recent achievements and future. Folia Medica (Plovdiv) 2000; 42: 17–22
9.
go back to reference Dichter MA. Emerging insights into mechanisms of epilepsy: implications for new antiepileptic drug development. Epilepsia 1994; 35 Suppl. 4: S51–7CrossRef Dichter MA. Emerging insights into mechanisms of epilepsy: implications for new antiepileptic drug development. Epilepsia 1994; 35 Suppl. 4: S51–7CrossRef
10.
go back to reference Dalby NO, Mody I. The process of epileptogenesis: a pathophysiological approach. Curr Opin Neurol 2001; 14: 187–92PubMedCrossRef Dalby NO, Mody I. The process of epileptogenesis: a pathophysiological approach. Curr Opin Neurol 2001; 14: 187–92PubMedCrossRef
11.
go back to reference Babb TL. Synaptic reorganizations in human and rat hippocampal epilepsy. Adv Neurol 1999; 79: 763–79PubMed Babb TL. Synaptic reorganizations in human and rat hippocampal epilepsy. Adv Neurol 1999; 79: 763–79PubMed
12.
go back to reference Engel Jr J. Clinical neurophysiology, neuroimaging, and the surgical treatment of epilepsy. Curr Opin Neurol Neurosurg 1993; 6: 240–9PubMed Engel Jr J. Clinical neurophysiology, neuroimaging, and the surgical treatment of epilepsy. Curr Opin Neurol Neurosurg 1993; 6: 240–9PubMed
13.
go back to reference Cendes F, Andermann F, Dubeau F, et al. Early childhood prolonged febrile convulsions, atrophy and sclerosis of mesial structures, and temporal lobe epilepsy: an MRI volumetric study. Neurology 1993; 43: 1083–7PubMedCrossRef Cendes F, Andermann F, Dubeau F, et al. Early childhood prolonged febrile convulsions, atrophy and sclerosis of mesial structures, and temporal lobe epilepsy: an MRI volumetric study. Neurology 1993; 43: 1083–7PubMedCrossRef
14.
go back to reference Bjorholt PG, Nakken KO, Rohme K, et al. Leisure time habits and physical fitness in adults with epilepsy. Epilepsia 1990; 31: 83–7PubMedCrossRef Bjorholt PG, Nakken KO, Rohme K, et al. Leisure time habits and physical fitness in adults with epilepsy. Epilepsia 1990; 31: 83–7PubMedCrossRef
15.
go back to reference Nakken KO, Bjorholt PG, Johannessen SI, et al. Effect of physical training on aerobic capacity, seizure occurrence, and serum level of antiepileptic drugs in adults with epilepsy. Epilepsia 1990; 31 (1): 88–94PubMedCrossRef Nakken KO, Bjorholt PG, Johannessen SI, et al. Effect of physical training on aerobic capacity, seizure occurrence, and serum level of antiepileptic drugs in adults with epilepsy. Epilepsia 1990; 31 (1): 88–94PubMedCrossRef
16.
go back to reference Steinhoff BJ, Neususs K, Thegeder H, et al. Leisure time activity and physical fitness in patients with epilepsy. Epilepsia 1996; 37 (12): 1221–7PubMedCrossRef Steinhoff BJ, Neususs K, Thegeder H, et al. Leisure time activity and physical fitness in patients with epilepsy. Epilepsia 1996; 37 (12): 1221–7PubMedCrossRef
17.
go back to reference Wong J. Wirrell E. Physical activity in children/teens with epilepsy compared with that in their siblings without epilepsy. Epilepsia 2006; 47 (3): 631–9PubMedCrossRef Wong J. Wirrell E. Physical activity in children/teens with epilepsy compared with that in their siblings without epilepsy. Epilepsia 2006; 47 (3): 631–9PubMedCrossRef
18.
go back to reference American Medical Association Committee on the Medical Aspects of Sports. Convulsive disorders and participation in sports and physical education. JAMA 1968; 206: 1291PubMedCrossRef American Medical Association Committee on the Medical Aspects of Sports. Convulsive disorders and participation in sports and physical education. JAMA 1968; 206: 1291PubMedCrossRef
19.
go back to reference American Academy of Pediatrics Committee on Children with Handicaps. The epileptic child and competitive school athletics. Pediatrics 1968; 42: 700–2PubMed American Academy of Pediatrics Committee on Children with Handicaps. The epileptic child and competitive school athletics. Pediatrics 1968; 42: 700–2PubMed
20.
go back to reference American Medical Association Committee on the Medical Aspects of Sports. Epileptics and contact sports. JAMA 1974; 229: 820–82PubMedCrossRef American Medical Association Committee on the Medical Aspects of Sports. Epileptics and contact sports. JAMA 1974; 229: 820–82PubMedCrossRef
21.
go back to reference American Academy of Pediatrics Committee on Children with Handicaps and Committee on Sports Medicine. Sports and the child with epilepsy. Pediatrics 1983; 72: 884–5PubMed American Academy of Pediatrics Committee on Children with Handicaps and Committee on Sports Medicine. Sports and the child with epilepsy. Pediatrics 1983; 72: 884–5PubMed
22.
go back to reference Commission of Pediatrics of the International League Against Epilepsy. Restrictions for children with epilepsy. Epilepsia 1997; 38: 54–6CrossRef Commission of Pediatrics of the International League Against Epilepsy. Restrictions for children with epilepsy. Epilepsia 1997; 38: 54–6CrossRef
23.
go back to reference Roth DL, Goode KT, Williams VL, et al. Physical exercise, stressful life experience, and depression in adults with epilepsy. Epilepsia 1994; 35 (6): 1248–55PubMedCrossRef Roth DL, Goode KT, Williams VL, et al. Physical exercise, stressful life experience, and depression in adults with epilepsy. Epilepsia 1994; 35 (6): 1248–55PubMedCrossRef
24.
go back to reference Jalava M, Sillanpaa M. Physical activity, health–related fitness, and health experience in adults with childhood—onset epilepsy: a controlled study. Epilepsia 1997; 38 (4): 424–9PubMedCrossRef Jalava M, Sillanpaa M. Physical activity, health–related fitness, and health experience in adults with childhood—onset epilepsy: a controlled study. Epilepsia 1997; 38 (4): 424–9PubMedCrossRef
25.
go back to reference Eriksen HR, Ellertsen B, Gronningsaeter H, et al. Physical exercise in women with intractable epilepsy. Epilepsy 1994; 35: 1256–64CrossRef Eriksen HR, Ellertsen B, Gronningsaeter H, et al. Physical exercise in women with intractable epilepsy. Epilepsy 1994; 35: 1256–64CrossRef
26.
go back to reference LS Denio, ME Drake, Pakalnis A. The effect of exercise on seizure frequency. J Med 1989; 20 (2): 171–6PubMed LS Denio, ME Drake, Pakalnis A. The effect of exercise on seizure frequency. J Med 1989; 20 (2): 171–6PubMed
27.
28.
go back to reference Arida RM, Scorza FA, Albuquerque M, et al. Evaluation of physical exercise habits in Brazilian patients with epilepsy. Epilepsy Behav 2003; 4: 507–10PubMedCrossRef Arida RM, Scorza FA, Albuquerque M, et al. Evaluation of physical exercise habits in Brazilian patients with epilepsy. Epilepsy Behav 2003; 4: 507–10PubMedCrossRef
29.
go back to reference Aisenson MR. Accidental injuries in epileptic children. Pediatrics 1948; 2: 85–8PubMed Aisenson MR. Accidental injuries in epileptic children. Pediatrics 1948; 2: 85–8PubMed
30.
go back to reference Pearn J, Bart R, Yamaoka R. Drowning risks to epileptic children: a study from Havaii. BMJ 1978; 2 (6147): 1284–5PubMedCrossRef Pearn J, Bart R, Yamaoka R. Drowning risks to epileptic children: a study from Havaii. BMJ 1978; 2 (6147): 1284–5PubMedCrossRef
31.
go back to reference Kemp AM, Sibert JR. Epilepsy in children and the risk of drowning. Arch Dis Child 1993; 68 (5): 684–5PubMedCrossRef Kemp AM, Sibert JR. Epilepsy in children and the risk of drowning. Arch Dis Child 1993; 68 (5): 684–5PubMedCrossRef
32.
go back to reference Ryan CA, Dowling G. Drowning deaths in people with epilepsy. CMAJ 1993; 148 (5): 781–4PubMed Ryan CA, Dowling G. Drowning deaths in people with epilepsy. CMAJ 1993; 148 (5): 781–4PubMed
33.
go back to reference Livingston SL, Berman W. Participation of epileptic patients in sports. JAMA 1983; 224 (2): 236–8CrossRef Livingston SL, Berman W. Participation of epileptic patients in sports. JAMA 1983; 224 (2): 236–8CrossRef
34.
go back to reference Haglund Y, Bergstrand G. Does Swedish amateur boxing lead to chronic brain damage? A retrospective study with CT and MRI. Acta Neurol Scand 1990; 82: 297–302PubMedCrossRef Haglund Y, Bergstrand G. Does Swedish amateur boxing lead to chronic brain damage? A retrospective study with CT and MRI. Acta Neurol Scand 1990; 82: 297–302PubMedCrossRef
35.
go back to reference Annegers JF, Hauser WA, Coan SP, et al. A population—based study of seizures after traumatic brain injuries. N Engl J Med 1998; 338: 20–4PubMedCrossRef Annegers JF, Hauser WA, Coan SP, et al. A population—based study of seizures after traumatic brain injuries. N Engl J Med 1998; 338: 20–4PubMedCrossRef
36.
go back to reference van Linschoten R, Backx FJG, Mulder OGM, et al. Epilepsy and sports. Sports Med 1990; 10 (1): 9–19PubMedCrossRef van Linschoten R, Backx FJG, Mulder OGM, et al. Epilepsy and sports. Sports Med 1990; 10 (1): 9–19PubMedCrossRef
37.
38.
go back to reference Korczyn AD. Participation of epileptic patients in sports. J Sports Med 1979; 19: 195–8 Korczyn AD. Participation of epileptic patients in sports. J Sports Med 1979; 19: 195–8
39.
go back to reference Schmitt B, Thun-Hohenstein L, Vontobel H, et al. Seizures induced by physical exercise: report of two cases. Neuropediatrics 1994; 25 (1): 51–3PubMedCrossRef Schmitt B, Thun-Hohenstein L, Vontobel H, et al. Seizures induced by physical exercise: report of two cases. Neuropediatrics 1994; 25 (1): 51–3PubMedCrossRef
40.
go back to reference Simpson RK, Grossman RG. Seizures after jogging [letter]. N Engl J Med 1989; 321: 835PubMed Simpson RK, Grossman RG. Seizures after jogging [letter]. N Engl J Med 1989; 321: 835PubMed
41.
go back to reference Werk MA. Idiopathic generalized tonic—clonic seizures limited to exercise in a young adult. Epilepsy Behav 2005; 6 (1): 98–101CrossRef Werk MA. Idiopathic generalized tonic—clonic seizures limited to exercise in a young adult. Epilepsy Behav 2005; 6 (1): 98–101CrossRef
42.
go back to reference Sturm JW, Fedi M, Berkovic SF, et al. Exercise—induced temporal lobe epilepsy. Neurology 2002; 59 (8): 1246–8PubMedCrossRef Sturm JW, Fedi M, Berkovic SF, et al. Exercise—induced temporal lobe epilepsy. Neurology 2002; 59 (8): 1246–8PubMedCrossRef
43.
go back to reference Gotze W, Kubicki ST, Munter M, et al. Effect of physical exercise on seizure threshold. Dis Nerv Syst 1967; 28: 664–7PubMed Gotze W, Kubicki ST, Munter M, et al. Effect of physical exercise on seizure threshold. Dis Nerv Syst 1967; 28: 664–7PubMed
44.
go back to reference Kuijer A. Epilepsy and exercise, electroencephalographical and biochemical studies. In: Wada JA, Penry JK, editors. Advances in epileptology: the 10th Epilepsy International Symposium. New York: Raven Press, 1980: 543 Kuijer A. Epilepsy and exercise, electroencephalographical and biochemical studies. In: Wada JA, Penry JK, editors. Advances in epileptology: the 10th Epilepsy International Symposium. New York: Raven Press, 1980: 543
45.
go back to reference Cordova F. Epilepsy and sport. Aust Fam Physician 1993; 22: 558–62PubMed Cordova F. Epilepsy and sport. Aust Fam Physician 1993; 22: 558–62PubMed
46.
go back to reference Albrecht H. Endorphins, sport, and epilepsy: getting fit or having one [letter]. N Z Med J 1986; 99: 915PubMed Albrecht H. Endorphins, sport, and epilepsy: getting fit or having one [letter]. N Z Med J 1986; 99: 915PubMed
47.
go back to reference Temkin NR, Davis GR. Stress as risk factors for seizures among adults with epilepsy. Epilepsia 1984; 25: 450–6PubMedCrossRef Temkin NR, Davis GR. Stress as risk factors for seizures among adults with epilepsy. Epilepsia 1984; 25: 450–6PubMedCrossRef
48.
go back to reference McLaurin R. Epilepsy and contact sports: factors contraindicating participation. JAMA 1973; 225: 285–7PubMedCrossRef McLaurin R. Epilepsy and contact sports: factors contraindicating participation. JAMA 1973; 225: 285–7PubMedCrossRef
49.
go back to reference Boucharlat J, Maitre A, Ledru J. Sport et epilepsy de l’enfant. Ann Med—Psychol 1973; 131: 392–401 Boucharlat J, Maitre A, Ledru J. Sport et epilepsy de l’enfant. Ann Med—Psychol 1973; 131: 392–401
50.
go back to reference Bennett HT, Wagner T. Acute hyponatremia and seizures in an infant after a swimming lesson. Pediatrics 1983; 72: 125–7PubMed Bennett HT, Wagner T. Acute hyponatremia and seizures in an infant after a swimming lesson. Pediatrics 1983; 72: 125–7PubMed
51.
go back to reference Noakes ID, Goodwin N, Raymer BL, et al. Water intoxication, a possible complication during endurance exercise. Med Sci Sports Exerc 1984; 17: 370–5 Noakes ID, Goodwin N, Raymer BL, et al. Water intoxication, a possible complication during endurance exercise. Med Sci Sports Exerc 1984; 17: 370–5
52.
go back to reference Biswas R, Parajuli R, Naik L, et al. A conscientious hypertensive who had seizures after a trek. Int J Clin Pract 2003; 57 (5): 449–50PubMed Biswas R, Parajuli R, Naik L, et al. A conscientious hypertensive who had seizures after a trek. Int J Clin Pract 2003; 57 (5): 449–50PubMed
53.
go back to reference French JK. Hypoglycaemia—induced seizures following a marathon [letter]. NZ Med J 1983; 96: 407 French JK. Hypoglycaemia—induced seizures following a marathon [letter]. NZ Med J 1983; 96: 407
54.
go back to reference Millington JT. Should epileptics scuba dive? [letter]. JAMA 1985; 254 (22): 3182–3CrossRef Millington JT. Should epileptics scuba dive? [letter]. JAMA 1985; 254 (22): 3182–3CrossRef
55.
go back to reference van Willigen J. Running and exhaustion; hyperthermia in a moderate climate [in Dutch]. Nederlands Tijdschrift voor Geneeskunde 1988; 132: 437–40PubMed van Willigen J. Running and exhaustion; hyperthermia in a moderate climate [in Dutch]. Nederlands Tijdschrift voor Geneeskunde 1988; 132: 437–40PubMed
56.
go back to reference Esquivel E, Chaussain M, Plouin P, et al. Physical exercise and voluntary hyperventilation in childhood absence epilepsy. Electroenceph Clin Neurophysiol 1991; 79: 127–32PubMedCrossRef Esquivel E, Chaussain M, Plouin P, et al. Physical exercise and voluntary hyperventilation in childhood absence epilepsy. Electroenceph Clin Neurophysiol 1991; 79: 127–32PubMedCrossRef
57.
go back to reference Wasserman K, Wipp B, Koyal S, et al. Anaerobic threshold and respiratory gas exchange during exercise. J Appl Physiol 1973; 35: 236–43PubMed Wasserman K, Wipp B, Koyal S, et al. Anaerobic threshold and respiratory gas exchange during exercise. J Appl Physiol 1973; 35: 236–43PubMed
58.
go back to reference Loscher W, Schmidt D. New drugs for the treatment of epilepsy. Curr Opin Invest Drugs 1993; 2: 1067–95 Loscher W, Schmidt D. New drugs for the treatment of epilepsy. Curr Opin Invest Drugs 1993; 2: 1067–95
59.
go back to reference Loscher W, Schmidt D. Strategies in antiepileptic drug development: is rational drug design superior to random screening and structural variation? Epilepsy Res 1994; 17: 95–134PubMedCrossRef Loscher W, Schmidt D. Strategies in antiepileptic drug development: is rational drug design superior to random screening and structural variation? Epilepsy Res 1994; 17: 95–134PubMedCrossRef
60.
go back to reference Wolf P. Epileptic seizures and syndromes. London: John Libbey, 1994 Wolf P. Epileptic seizures and syndromes. London: John Libbey, 1994
61.
go back to reference Goodman JH. Experimental models of status epilepticus. In: Peterson SL, Albertson TE, editors. Neuropharmacological methods in epilepsy research. Boca Raton (FL): CRC Press, 1998: 95–125 Goodman JH. Experimental models of status epilepticus. In: Peterson SL, Albertson TE, editors. Neuropharmacological methods in epilepsy research. Boca Raton (FL): CRC Press, 1998: 95–125
62.
go back to reference Arida RM, Vieira AJ, Cavalheiro EA. Effect of physical exercise on kindling development. Epilepsy Res 1998; 30: 127–32PubMedCrossRef Arida RM, Vieira AJ, Cavalheiro EA. Effect of physical exercise on kindling development. Epilepsy Res 1998; 30: 127–32PubMedCrossRef
63.
go back to reference Arida RM, Scorza FA, Santos NF, et al. Effect of physical exercise on seizure occurrence in a model of temporal lobe epilepsy in rats. Epilepsy Res 1999; 37 (1): 45–52PubMedCrossRef Arida RM, Scorza FA, Santos NF, et al. Effect of physical exercise on seizure occurrence in a model of temporal lobe epilepsy in rats. Epilepsy Res 1999; 37 (1): 45–52PubMedCrossRef
64.
go back to reference Arida RM, Fernandes MJS, Scorza FA, et al. Physical training does not influence interictal LCMRglu in pilocarpine—treated rats with epilepsy. Physiol Behav 2003; 79: 789–94PubMedCrossRef Arida RM, Fernandes MJS, Scorza FA, et al. Physical training does not influence interictal LCMRglu in pilocarpine—treated rats with epilepsy. Physiol Behav 2003; 79: 789–94PubMedCrossRef
65.
go back to reference Arida RM, Sanabria ERG, Silva AC, et al. Physical training reverts hippocampal electrophysiological changes in rats submitted to the pilocarpine model of epilepsy. Physiol Behav 2004;83: 165–71PubMed Arida RM, Sanabria ERG, Silva AC, et al. Physical training reverts hippocampal electrophysiological changes in rats submitted to the pilocarpine model of epilepsy. Physiol Behav 2004;83: 165–71PubMed
66.
go back to reference Arida RM, Scorza CA, Scorza FA, et al. Effects of different types of physical exercise on the staining of parvalbuminpositive neurons in the hippocampal formation of rats with epilepsy. Prog Neuro—Psychopharmacol Biol Psychiatry 2007; 31: 814–22CrossRef Arida RM, Scorza CA, Scorza FA, et al. Effects of different types of physical exercise on the staining of parvalbuminpositive neurons in the hippocampal formation of rats with epilepsy. Prog Neuro—Psychopharmacol Biol Psychiatry 2007; 31: 814–22CrossRef
67.
go back to reference Racine RJ. Modification of seizure activity by electrical stimulation II: motor seizure. Electroenceph Clin Neurophysiol 1972; 32: 281–94PubMedCrossRef Racine RJ. Modification of seizure activity by electrical stimulation II: motor seizure. Electroenceph Clin Neurophysiol 1972; 32: 281–94PubMedCrossRef
68.
go back to reference Brown B, Van Huss C. Exercise and rat brain catecholamines. J Appl Physiol 1973; 34 (5): 664–9PubMed Brown B, Van Huss C. Exercise and rat brain catecholamines. J Appl Physiol 1973; 34 (5): 664–9PubMed
69.
go back to reference De Castro J, Duncan G. Operantly conditioned running: effects on brain catecholamine concentrations and receptor densities in the rat. Pharmacol Biochem Behav 1985; 23: 495–500PubMedCrossRef De Castro J, Duncan G. Operantly conditioned running: effects on brain catecholamine concentrations and receptor densities in the rat. Pharmacol Biochem Behav 1985; 23: 495–500PubMedCrossRef
70.
go back to reference Westerberg V, Lewis J, Corcoran ME. Depletion of noradrenaline fails to affect kindling seizures. Exp Neurol 1984; 84: 237–40PubMedCrossRef Westerberg V, Lewis J, Corcoran ME. Depletion of noradrenaline fails to affect kindling seizures. Exp Neurol 1984; 84: 237–40PubMedCrossRef
71.
go back to reference Bortolotto ZA, Cavalheiro EA. Effect of DSP4 on hippocampal kindling in rats. Pharmacol Biochem Behav 1986; 24: 777–9PubMedCrossRef Bortolotto ZA, Cavalheiro EA. Effect of DSP4 on hippocampal kindling in rats. Pharmacol Biochem Behav 1986; 24: 777–9PubMedCrossRef
72.
go back to reference Welsh KA, Gold PE. Attenuation of epileptogenesis: proactive effect of a single epinephrine injection on amygdaloid kindling. Behav Neural Biol 1984; 40: 179–85PubMedCrossRef Welsh KA, Gold PE. Attenuation of epileptogenesis: proactive effect of a single epinephrine injection on amygdaloid kindling. Behav Neural Biol 1984; 40: 179–85PubMedCrossRef
73.
go back to reference Le Gal La Salle, G. Amygdaloid kindling in the rat: regional differences and general properties. In: Wada JA, editor. Kindling 2. New York: Raven Press, 1981 Le Gal La Salle, G. Amygdaloid kindling in the rat: regional differences and general properties. In: Wada JA, editor. Kindling 2. New York: Raven Press, 1981
74.
go back to reference Vissing J, Andersen M, Diemer NH. Exercise—induced changes in local cerebral glucose utilization in the rat. J Cereb Blood Flow Metab 1996; 16: 729–36PubMedCrossRef Vissing J, Andersen M, Diemer NH. Exercise—induced changes in local cerebral glucose utilization in the rat. J Cereb Blood Flow Metab 1996; 16: 729–36PubMedCrossRef
75.
go back to reference Sloviter RS. Calcium—binding protein (calbindin—D28k) and parvalbumin immunocytochemistry: localization in the rat hippocampus with specific reference to the selective vulnerability of hippocampal neurons to seizure activity. J Comp Neurol 1989; 280 (2): 183–96PubMedCrossRef Sloviter RS. Calcium—binding protein (calbindin—D28k) and parvalbumin immunocytochemistry: localization in the rat hippocampus with specific reference to the selective vulnerability of hippocampal neurons to seizure activity. J Comp Neurol 1989; 280 (2): 183–96PubMedCrossRef
76.
go back to reference Freund TF, Ylinen A, Miettinen R, et al. Pattern of neuronal death in the rat hippocampus after status epilepticus: relationship to calcium binding protein content and ischemic vulnerability. Brain Res Bull 1991;28: 27–38CrossRef Freund TF, Ylinen A, Miettinen R, et al. Pattern of neuronal death in the rat hippocampus after status epilepticus: relationship to calcium binding protein content and ischemic vulnerability. Brain Res Bull 1991;28: 27–38CrossRef
77.
go back to reference Celio MR. Calbindin D28k and parvalbumin in the rat nervous system. Neuroscience 1990; 35: 375–475PubMedCrossRef Celio MR. Calbindin D28k and parvalbumin in the rat nervous system. Neuroscience 1990; 35: 375–475PubMedCrossRef
78.
go back to reference Freund TF, Buzsáki G. Interneurons of the hippocampus. Hippocampus 1996; 6: 345–470 Freund TF, Buzsáki G. Interneurons of the hippocampus. Hippocampus 1996; 6: 345–470
Metadata
Title
Physical Activity and Epilepsy
Proven and Predicted Benefits
Authors
Dr Ricardo M. Arida
Esper A. Cavalheiro
Antonio C. da Silva
Fulvio A. Scorza
Publication date
01-07-2008
Publisher
Springer International Publishing
Published in
Sports Medicine / Issue 7/2008
Print ISSN: 0112-1642
Electronic ISSN: 1179-2035
DOI
https://doi.org/10.2165/00007256-200838070-00006

Other articles of this Issue 7/2008

Sports Medicine 7/2008 Go to the issue