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Lasers in Medical Science
Published in: Lasers in Medical Science 3/2014

01-05-2014 | Original Article

Photodynamic effects of zinc oxide nanowires in skin cancer and fibroblast

Authors: Muhammad Fakhar-e-Alam, S. Kishwar, M. Willander

Published in: Lasers in Medical Science | Issue 3/2014

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Abstract

Cytotoxic effects of zinc oxide (ZnO) nanomaterials, individual and conjugated with a photosensitizer (protoporphyrin IX), were studied in the presence and absence of ultraviolet light exposure (240 nm of light wavelength for a very short time exposure) in cell cultures of human normal and cancerous skin models. Zinc Oxide nanowires (ZnO NWs) were grown on the capillary tip and conjugated with protoporphyrin IX (PpIX). This coated tip was used as tool/pointer for intracellular drug delivery protocol in suggested normal as well as carcinogenic cellular models. After true delivery of optimal drug, the labelled biological model was irradiated with UV-A, which led to a loss of mitochondrial membrane potential, as tested by neutral red assay (NRA).
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Metadata
Title
Photodynamic effects of zinc oxide nanowires in skin cancer and fibroblast
Authors
Muhammad Fakhar-e-Alam
S. Kishwar
M. Willander
Publication date
01-05-2014
Publisher
Springer London
Published in
Lasers in Medical Science / Issue 3/2014
Print ISSN: 0268-8921
Electronic ISSN: 1435-604X
DOI
https://doi.org/10.1007/s10103-013-1501-4

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