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Breast Cancer
Published in: Breast Cancer 2/2014

01-03-2014 | Original Article

Photoacoustic mammography: initial clinical results

Authors: Toshiyuki Kitai, Masae Torii, Tomoharu Sugie, Shotaro Kanao, Yoshiki Mikami, Tsuyoshi Shiina, Masakazu Toi

Published in: Breast Cancer | Issue 2/2014

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Abstract

Purpose

Photoacoustic tomography can image the hemoglobin distribution and oxygenation state inside tissue with high spatial resolution. The purpose of this study is to investigate its clinical usefulness for diagnosis of breast cancer and evaluation of therapeutic response in relation to other diagnostic modalities.

Materials and methods

Using a prototype machine for photoacoustic mammography (PAM), 27 breast tumor lesions, including 21 invasive breast cancer (IBC), five ductal carcinoma in situ (DCIS), and one phyllodes tumor, were measured. Nine out of twenty-one IBC patients had received primary systemic therapy (PST).

Results

Eight out of twelve IBC without PST were visible. Notably, detection was possible in all five cases with DCIS, whereas it was not in one case with phyllodes tumor. Seven out of nine IBC with PST were assigned as visible in spite of decreased size of tumor after PST. The mean value of hemoglobin saturation in the visible lesions was 78.6 %, and hemoglobin concentration was 207 μM. The tumor images of PAM were comparable to those of magnetic resonance imaging (MRI).

Conclusions

It is suggested that PAM can image tumor vascularity and oxygenation, which may be useful for diagnosis and characterization of breast cancer.
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Metadata
Title
Photoacoustic mammography: initial clinical results
Authors
Toshiyuki Kitai
Masae Torii
Tomoharu Sugie
Shotaro Kanao
Yoshiki Mikami
Tsuyoshi Shiina
Masakazu Toi
Publication date
01-03-2014
Publisher
Springer Japan
Published in
Breast Cancer / Issue 2/2014
Print ISSN: 1340-6868
Electronic ISSN: 1880-4233
DOI
https://doi.org/10.1007/s12282-012-0363-0

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