Published in:
Open Access
01-12-2015 | Meeting abstract
PHLPP1 phosphatase inhibition in hypothalamus restores insulin signaling and action and reduces adiposity in obese rats
Authors:
Bruna dos Santos Cardoso, Gisele Castro, Natália Ferreira Mendes, Paula Gabriele Fernandes Quaresma, Tamires Marques Zanotto, Mario Jose Abdalla Saad, Patrícia de Oliveira Prada
Published in:
Diabetology & Metabolic Syndrome
|
Special Issue 1/2015
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Excerpt
Obesity results from imbalance between food intake and energy expenditure. The energy homeostasis is regulated by hypothalamic neurons that receive different neural, hormonal and metabolic signals. Insulin is one of the main hormones that regulate energy homeostasis and acts through a cascade of intracellular signaling that depends on the activation of several proteins, such as Akt. Our hypothesis is that PH domain and Leucine rich repeat Protein Phosphatase 1 (PHLPP1) inhibits Akt activity by dephosphorylating serine 473 residues, impairing the insulin action in the hypothalamus. However, PHLPP1 expression and the role played by it on the hypothalamus of diet induced obesity (DIO) animals are not fully understood. …
