Published in:
Open Access
01-12-2021 | Phenprocoumon | Case report
Factor IX p.A37V mutation causes severe bleeding in a patient with phenprocoumon therapy
Authors:
Nils Mülling, Vivian Rosery, H. Christian Reinhardt, Maher Hanoun
Published in:
European Journal of Medical Research
|
Issue 1/2021
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Abstract
Background
Bleeding is the most common complication of oral anticoagulants, due to inadequate dosing.
Case presentation
This report describes the clinical course of a patient who developed severe bleeding under therapy with phenprocoumon, despite an INR in the lower therapeutic range. Strikingly, aPTT was prolonged, while factor IX activity was significantly reduced. Acquired hemophilia was excluded, due to missing detection of inhibitors. Finally, sequencing part of the factor IX gene including nucleotide position c.110 revealed a hemizygous factor IX mutation c.110C > T p (Ala37Val).
Conclusions
In rare cases, missense mutations in factor IX propeptide are associated with severe bleeding complications. The substitution of alanin at position 37 to either valin or threonin (Ala37Val or Ala37Thr) leads to hypersensitivity to vitamin k antagonists.