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Critical Care
Published in: Critical Care 1/2016

Open Access 01-12-2016 | Letter

Pharmacokinetics of anidulafungin during venovenous extracorporeal membrane oxygenation

Authors: Gerardo Aguilar, Rafael Ferriols, José A. Carbonell, Carlos Ezquer, José Miguel Alonso, Abigail Villena, Jaume Puig, David Navarro, Manuel Alós, F. Javier Belda

Published in: Critical Care | Issue 1/2016

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Excerpt

Echinocandins are currently considered the first-line treatment for invasive candidiasis (IC) in the intensive care unit (ICU) [1, 2]. However, extracorporeal membrane oxygenation (ECMO), a rescue therapy used in patients with severe acute respiratory distress syndrome (ARDS) [3], could alter the pharmacokinetics of certain drugs [4]. We prescribed anidulafungin for suspected IC in a patient with severe ARDS on ECMO and measured the plasma concentrations of the drug using high-performance liquid chromatography (HPLC). …
Literature
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Cornely OA, Bassetti M, Calandra T, ESCMID Fungal Infection Study Group, et al. ESCMID guideline for the diagnosis and management of Candida diseases 2012: non-neutropenic adult patients. Clin Microbiol Infect. 2012;18(Suppl. 7):19–37.
2.
Pappas PG, Kauffman CA, Andes DR, et al. Clinical Practice Guideline for the Management of Candidiasis: 2016 Update by the Infectious Diseases Society of America. Clin Infect Dis. 2016;62(4):e1–50.CrossRefPubMed
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Liu P, Ruhnke M, Meersseman W, Paiva JA, Kantecki M, Damle B. Pharmacokinetics of anidulafungin in critically ill patients with candidemia/invasive candidiasis. Antimicrob Agents Chemother. 2013;57(4):1672–6.CrossRefPubMedPubMedCentral
Metadata
Title
Pharmacokinetics of anidulafungin during venovenous extracorporeal membrane oxygenation
Authors
Gerardo Aguilar
Rafael Ferriols
José A. Carbonell
Carlos Ezquer
José Miguel Alonso
Abigail Villena
Jaume Puig
David Navarro
Manuel Alós
F. Javier Belda
Publication date
01-12-2016
Publisher
BioMed Central
Published in
Critical Care / Issue 1/2016
Electronic ISSN: 1364-8535
DOI
https://doi.org/10.1186/s13054-016-1501-4

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